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21.发明申请Method for the production of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acids 失效制备取代的1,2,3,4-四氢喹啉-2-羧酸的方法公开(公告)号：US20050004366A1
公开(公告)日：2005-01-06
申请号：US10896728
申请日：2004-07-22
申请人： Michael Przewosny
发明人： Michael Przewosny
IPC分类号： C07D215/48 , C07D221/16 , C07D221/22
CPC分类号： C07D215/48 , C07D221/16
摘要： The invention relates to a method for the production of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acids, i.e. 7,9-dichlor-3a,4,5,9b-tetrahydro-3H-cyclopental[c]quinoline-4-carboxylic acid.
摘要翻译： 本发明涉及制备取代的1,2,3,4-四氢喹啉-2-羧酸的方法，即7,9-二氯-3a，4,5,9b-四氢-3H-环戊并[c]喹啉 -4-羧酸。
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22.发明授权Substituted pyrrolidine-2,3,4-trione 3-oxime derivatives which are active as NMDA receptor antagonists 失效作为NMDA受体拮抗剂有活性的取代的吡咯烷-2,3,4-三酮3-肟衍生物公开(公告)号：US06716872B2
公开(公告)日：2004-04-06
申请号：US10066801
申请日：2002-02-06
IPC分类号： A61K3140
CPC分类号： C07D207/02
摘要： Novel substituted pyrrolidine-2,3,4-trione compounds of formula I and methods for preparing the compounds. Also disclosed are pharmarceutical compositions comprising the compounds and methods of using the compounds for treating pain, anxiety and various other diseases or conditions.
摘要翻译： 式I的新型取代的吡咯烷-2,3,4-三酮化合物及其制备方法。 还公开了包含该化合物的药物组合物和使用该化合物治疗疼痛，焦虑和各种其它疾病或病症的方法。
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23.发明授权Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions 失效香草酸受体配体，含有它们的药物组合物，其制备方法，及其用于治疗疼痛和其它病症的用途公开(公告)号：US08642775B2
公开(公告)日：2014-02-04
申请号：US12103198
申请日：2008-04-15
申请人： Robert Frank , Gregor Bahrenberg , Thomas Christoph , Klaus Schiene , Jean De Vry , Derek Saunders , Michael Przewosny , Bernd Sundermann , Jewoo Lee
发明人： Robert Frank , Gregor Bahrenberg , Thomas Christoph , Klaus Schiene , Jean De Vry , Derek Saunders , Michael Przewosny , Bernd Sundermann , Jewoo Lee
IPC分类号： C07D213/62 , A61K31/44
CPC分类号： C07D213/74 , C07D213/64 , C07D213/70
摘要： Vanilloid receptor ligand compounds corresponding to formula I: a process for producing such compounds, pharmaceutical compositions containing them, and the use of such compounds to treat pain and various other vanilloid receptor mediated conditions.
摘要翻译： 对应于式I的香草酸受体配体化合物：制备这种化合物的方法，含有它们的药物组合物，以及这些化合物用于治疗疼痛和各种其它香草素受体介导的病症的用途。
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24.发明授权Substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine compounds 失效取代的C-呋喃-2-基 - 甲胺和C-噻吩-2-基 - 甲胺化合物公开(公告)号：US07317034B2
公开(公告)日：2008-01-08
申请号：US11072962
申请日：2005-03-07
IPC分类号： A61K31/381 , A61K31/4155 , C07D333/20 , C07D333/38 , C07D409/12
CPC分类号： C07D307/68
摘要： Substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine compounds, processes for their preparation, medicaments and pharmaceutical compositions containing them, and their use in treatment methods and in the preparation of analgesics, in the preparation of a local anaesthetic, an antiarrhythmic, an antiemetic, a nootropic agent and/or a medicament for the treatment and/or prophylaxis of cardiovascular diseases, urinary incontinence, diarrhea, pruritus and/or inflammations, and/or a medicament for the treatment of depression and/or alcohol and/or drug and/or medicament abuse, and/or a medicament for increasing vigilance.
摘要翻译： 取代的C-呋喃-2-基 - 甲胺和C-噻吩-2-基 - 甲胺化合物，其制备方法，含有它们的药物和药物组合物及其在治疗方法中的用途和在制备中的镇痛药 局部麻醉剂，抗心律失常药，止吐药，益智药和/或用于治疗和/或预防心血管疾病，尿失禁，腹泻，瘙痒和/或炎症的药物，和/或用于治疗 抑郁症和/或酒精和/或药物和/或药物滥用，和/或用于提高警惕性的药物。
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25.发明授权Substituted 1,5-dihydropyrrol-2-one derivatives active as NMDA receptor antagonists for treatment of states of pain 失效用作治疗疼痛状态的NMDA受体拮抗剂活性的取代的1,5-二氢吡咯-2-酮衍生物公开(公告)号：US06642267B2
公开(公告)日：2003-11-04
申请号：US10066800
申请日：2002-02-06
IPC分类号： A61K3140
CPC分类号： C07D207/44
摘要： A substituted 1,5-dihydropyrrol-2-one compound of formula I: and methods for preparing the compounds. Also disclosed are pharmarceutical compositions comprising the compounds and methods of using the compounds for the treatment or prophylaxis of pain, inflammatory and allergic reactions, depressions, drug abuse and various other diseases or conditions.
摘要翻译： 式I的取代的1,5-二氢吡咯-2-酮化合物及其制备方法。 还公开了包含该化合物的药物组合物和使用该化合物治疗或预防疼痛，炎症和过敏反应，沮丧，药物滥用和各种其它疾病或病症的方法。
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