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1362 条记录 (耗时 0.039 秒)

    Method for preparing pyridine compound substituted with trifluoromethylthio, difluoromethylthio or trifluoromethyl in meta position
    3.
    发明授权
    Method for preparing pyridine compound substituted with trifluoromethylthio, difluoromethylthio or trifluoromethyl in meta position 有权

    公开(公告)号：US11851408B2

    公开(公告)日：2023-12-26

    申请号：US18221902

    申请日：2023-07-14

    申请人： NANKAI UNIVERSITY

    发明人： Xiaochen Wang ,  Xinyue Zhou

    IPC分类号： C07D213/70 ,  B01J31/14

    CPC分类号： C07D213/70 ,  B01J31/146

    摘要： A method for preparing a pyridine compound substituted with trifluoromethylthio, difluoromethylthio or trifluoromethyl in the meta position is provided, which includes S1. in a glove box filled with nitrogen, adding a catalyst, a solvent, pinacolborane, and pyridine to a reaction flask, stirring the mixture, and performing a reaction at 40-100° C. for 2-12 hours to obtain dihydropyridine; S2. adding a trifluoromethylthio reagent, a difluoromethylthio reagent, or a trifluoromethyl reagent to the reaction flask, stirring the mixture, and performing a reaction at room temperature to 80° C. for 2-12 hours to obtain trifluoromethylthio-, difluoromethylthio- or trifluoromethyl-substituted dihydropyridine; and S3. placing the reaction flask in the air or adding 2,3-dichloro-5,6-dicyanobenzoquinone, stirring same, and performing a reaction at room temperature for 4-12 hours, followed by distillation under reduced pressure to remove the solvent and column chromatography separation to obtain the meta-substituted pyridine compound.