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21.发明公开公开(公告)号：US20230414276A1
公开(公告)日：2023-12-28
申请号：US18338741
申请日：2023-06-21
Applicant: Medtronic, Inc.
Inventor： Timothy G. Laske , Qingguo Zeng , Qing Lou , Mark T. Stewart , Brian T. Howard , Anthony W. Rorvick , Gregory S. Brumfield
IPC: A61B18/14
CPC classification number: A61B18/1492 , A61B2018/00875
Abstract: A method and a pulsed electric field (PEF) ablation instrument are provided. According to one aspect, a method in a PFA generator includes receiving electrical responses for each of at least one non-therapeutic waveform. The process also includes determining an electric field distribution based at least in part on the received electrical responses. The process further includes selecting a non-therapeutic waveform that produces an electric field distribution that satisfies criteria. The process also includes mapping the selected non-therapeutic waveform to an ablative waveform.
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公开(公告)号：US20230310072A1
公开(公告)日：2023-10-05
申请号：US18190695
申请日：2023-03-27
Applicant: Medtronic, Inc.
Inventor： Mark T. Stewart , Brian T. Howard , Timothy G. Laske
IPC: A61B18/14
CPC classification number: A61B18/1492 , A61B2018/00613
Abstract: A method and system for directed pulsed electric field (PEF) ablation are disclosed. In one aspect, an irreversible electroporation (IRE) system includes processing circuitry configured to select a first set of electrodes positioned to produce a first electric field in a first direction in a region of tissue of a patient, and select a second set of electrodes positioned to produce a second electric field in a second direction in the region of tissue. The processing circuitry is configured to transmit a first IRE pulse to the first set of electrodes to cause emission of the first electric field and transmit a second IRE pulse to the second set of electrodes to cause emission of the second electric field. The first IRE pulse and the second IRE pulse are transmitted by the processing circuitry to control an electric field gradient along a path within the region of tissue.
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公开(公告)号：US20230310069A1
公开(公告)日：2023-10-05
申请号：US18183546
申请日：2023-03-14
Applicant: Medtronic, Inc.
Inventor： Mark T. Stewart , Brian T. Howard
IPC: A61B18/14
CPC classification number: A61B18/1492 , A61B2018/00577
Abstract: An example method for performing pulsed field ablation (PFA) includes determining, by a controller connected to a particular catheter and at a first time, to perform PFA using a linear PFA mode; responsive to determining to use the linear PFA mode, outputting, by the controller and to electrodes of the particular catheter, energy to cause the electrodes to generate a field with a geometry that is linear along an active portion of the particular catheter; determining, by the controller and at a second time, to perform PFA using a focal PFA mode; and responsive to determining to use the focal PFA mode, outputting, by the controller and to the electrodes of the particular catheter, energy to cause the electrodes to generate a field with a geometry that is focused at a tip of the particular catheter.
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公开(公告)号：US20230310068A1
公开(公告)日：2023-10-05
申请号：US18183527
申请日：2023-03-14
Applicant: Medtronic, Inc.
Inventor： Mark T. Stewart , Brian T. Howard
IPC: A61B18/14
CPC classification number: A61B18/1492 , A61B2018/1407 , A61B2018/1467 , A61B2018/1435 , A61B2018/00577
Abstract: An example catheter for performing pulsed field ablation (PFA) includes: an elongated structure defining a longitudinal axis; a plurality of electrodes carried on a distal portion of the elongated structure, the plurality of electrodes comprising: a tip electrode positioned at a distal tip of the elongated structure; a tip ring electrode adjacent to the tip electrode; a pair of ring electrodes; and one or more additional electrodes, wherein the pair of ring electrodes is disposed longitudinally along the elongated structure between the tip ring electrode and the one or more additional electrodes.
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公开(公告)号：US20220280229A1
公开(公告)日：2022-09-08
申请号：US17683635
申请日：2022-03-01
Applicant: Medtronic, Inc.
Inventor： Brian T. Howard , Steven J. Fraasch , Gonzalo Martinez , Mark T. Stewart , Sara A. Frantz , Lars M. Mattison
Abstract: A method and pulsed field ablation (PFA) system configured to provide variable impedance paths for delivery of electric fields to patient tissue using a PFA catheter are disclosed. According to one aspect, a method includes determining a current for each of a plurality of circuit paths, each circuit path including two electrodes. Each current may be determined based at least in part on: a desired voltage between the two electrodes; a tissue impedance between the two electrodes; and a parasitic impedance associated with the circuit path. The method also includes determining at least one of an excitation voltage and an input resistance for each circuit path of the plurality of circuit paths based at least in part on the determined current for the circuit path, parasitic impedances associated with the circuit path and a tissue impedance between the two electrodes in the circuit path.
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Patent Agency Ranking
公开(公告)号：US20250072963A1
公开(公告)日：2025-03-06
申请号：US18953637
申请日：2024-11-20
Applicant: Medtronic, Inc.
Inventor： Brian T. Howard , Mark T. Stewart , Lars M. Mattison
Abstract: A medical device including a catheter having a proximal portion and a distal portion. A plurality of electrodes is disposed along the distal portion, the plurality of electrodes including a first electrode pair having a first fixed polarity and a second electrode pair having a second fixed polarity different than the first fixed polarity. A first lumen extends through the distal portion, the first lumen includes a first conductor configured to connect to a first electrode of the first electrode pair and a second conductor configured to connect to a second electrode of the first electrode pair. A second lumen extends through the distal portion and separated from the first lumen, the second lumen includes a third conductor configured to connect to a first electrode of the second electrode pair and a fourth conductor configured to connect to a second electrode of the second electrode pair.
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公开(公告)号：US20230414275A1
公开(公告)日：2023-12-28
申请号：US18332953
申请日：2023-06-12
Applicant: Medtronic, Inc.
Inventor： Brian T. Howard , Megan M. Schmidt , Lars M. Mattison
CPC classification number: A61B18/1492 , A61B5/4848 , A61B18/1206 , A61B2018/00791
Abstract: A medical system includes a generator configured to generate pulsed electric field (PEF) energy. A medical device is in electrical communication with the generator and has a plurality of electrodes configured to deliver the PEF energy to a target tissue to create electroporated regions in the target tissue. A delivery element tracking system is in communication with the generator and the medical device. The tracking system has processing circuitry configured to: measure a position of at least one of the plurality of electrodes prior to delivery of PEF energy to the target tissue with respect to the target tissue and correlate a PEF field distribution based on the delivery of PEF energy to the target tissue to determine or modify at least one metric of a therapeutic effect from the PEF delivery at positions other than the measured location of the plurality of electrodes.
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公开(公告)号：US20230310871A1
公开(公告)日：2023-10-05
申请号：US18194911
申请日：2023-04-03
Applicant: Medtronic, Inc.
Inventor： Brian T. Howard , Timothy G. Laske , Alexander J. Hill , Anthony W. Rorvick , Robert C. Kowal
Abstract: Implantable medical device including a pulsed-voltage generator and one or more implantable electrical leads. In one example, the implantable medical device supports the defibrillator and ablation modalities characterized by different respective sets of waveform parameters, such as the pulse amplitude and width. In some examples, the implantable medical device also supports a pacing modality. The electrodes used for the different modalities are variously selected from a plurality of electrodes located in distal portions of the implantable electrical leads and on the exterior surface of the implantable device box. An electronic controller of the implantable medical device is wirelessly programmable to appropriately control, e.g., in a patient-specific manner, operations of the pulsed-voltage generator and transitions between different modalities. Various examples of the disclosed implantable medical device can beneficially be used to provide to a cardiac patient a greater variety of treatment options without having to replace the implantable medical device.
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公开(公告)号：US11633121B2
公开(公告)日：2023-04-25
申请号：US15669048
申请日：2017-08-04
Applicant: Medtronic, Inc.
Inventor： Brian T. Howard
Abstract: Devices, systems, and methods relating to a low-voltage, pre-treatment pulse routine for evaluating a potential for non-target tissue damage from the delivery of energy, such as electroporation energy to an area of target tissue. In one embodiment, a medical system includes a medical device having a treatment element; and a control unit in communication with the medical device, the control unit being configured to: deliver a low-voltage, pre-treatment pulse routine through the treatment element to an area of target tissue; determine whether the low-voltage, pre-treatment pulse routine has a stimulation effect on an area of non-target tissue; and deliver an ablation energy routine through the treatment element to the area of target tissue when the control unit determines that the low-voltage, pre-treatment pulse routine does not have a stimulation effect on the area of non-target tissue.
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30.发明授权公开(公告)号：US11612424B2
公开(公告)日：2023-03-28
申请号：US16676586
申请日：2019-11-07
Applicant: Medtronic, Inc.
Inventor： Steven J. Fraasch , Trenton J. Rehberger , Qin Zhang , Lynn A. Davenport , Steven V. Ramberg , Brian T. Howard , Mark T. Stewart , Alexander J. Hill , John Vandanacker
Abstract: Methods and systems for monitoring and modifying pulsed field ablation (PFA) energy delivery to prevent patient safety risks and/or delivery device failure. In particular, some embodiments provide methods and systems for detecting and preventing arcs and arc-induced plasma, and their causal events, during delivery of pulsed field ablation energy, as well as methods and systems for identifying conditions leading to potential delivery device failure and correcting charge imbalance or asymmetry.
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