公开(公告)号：US20230310061A1

公开(公告)日：2023-10-05

申请号：US18295416

申请日：2023-04-04

Applicant: Medtronic, Inc.

Inventor： Mark T. Stewart ,  Lars M. Mattison ,  Brian T. Howard ,  Damijan Miklavcic ,  Tadej Kotnik ,  Janja Dermol-Cerne ,  Tina Batista Napotnik

IPC: A61B18/12

CPC classification number: A61B18/1206 ,  A61B2017/00176

Abstract: A method of delivering pulsed electric field energy to perform ablation of a tissue includes providing a pulse train to an electrode. The pulse train may include a first set of pulses with a first pulse width to generate first electric field and a second set of pulses with a second pulse width greater than the first pulse width to generate a second electric field. The electrode may be positioned at a same position during generation of the first electric field and the second electric field. The first electric field may be configured to have a higher electroporation effect on the first elongated cells having a first orientation than on second elongated cells having a second orientation. The second electric field may be configured to have a higher electroporation effect on the second cells than on the first cells.

公开(公告)号：US11464968B2

公开(公告)日：2022-10-11

申请号：US16747767

申请日：2020-01-21

Applicant: Medtronic, Inc.

Inventor： Brian T. Howard

IPC: A61N1/32 ,  A61B5/00 ,  A61B5/053 ,  A61B18/12 ,  A61B5/318 ,  A61B18/00

Abstract: A method of delivering pulsed electrical energy to a target tissue region includes delivering a first therapeutic pulse, the delivering of the first therapeutic pulse includes delivering a first pulse for a first time period, the first pulse having a first voltage amplitude. A second pulse is delivered immediately after the first pulse for a second time period, the second pulse having a second voltage amplitude configured to electroporate the target tissue region, the second time period being less than the first time period. A third pulse is delivered without delay after the second pulse for a third time period, the third pulse having a third voltage amplitude being at least one from the group consisting of substantially the same as the first amplitude, larger than the first amplitude, and less than the first amplitude.

公开(公告)号：US11229478B2

公开(公告)日：2022-01-25

申请号：US15427534

申请日：2017-02-08

Applicant: Medtronic, Inc.

Inventor： Brian T. Howard ,  Steven J. Fraasch ,  Mark T. Stewart ,  John Vandanacker

IPC: A61B18/12 ,  A61B18/14 ,  A61N1/32 ,  G06F30/20 ,  A61B18/00

Abstract: A method of determining a pulsed field ablation waveform parameter for creating a desired lesion characteristic in cardiac tissue. The method of provides an electrosurgical generator configured to deliver electroporation pulses, the generator configured to: load predetermined waveform parameters (yi); load predetermined modeling data (xi); accept entry of a user inputted desired lesion characteristic (ui); and determine at least one corresponding pulsed field ablation waveform parameter based on (ui), (yi); and (xi).

公开(公告)号：US10569081B2

公开(公告)日：2020-02-25

申请号：US15448912

申请日：2017-03-03

Applicant: Medtronic, Inc.

Inventor： Brian T. Howard

IPC: A61N1/32 ,  A61B5/0402 ,  A61B5/00 ,  A61B5/053 ,  A61B18/12 ,  A61B18/00

Abstract: A method of delivering pulsed electrical energy to a target tissue region includes delivering a first therapeutic pulse, the delivering of the first therapeutic pulse includes delivering a first pulse for a first time period, the first pulse having a first voltage amplitude. A second pulse is delivered immediately after the first pulse for a second time period, the second pulse having a second voltage amplitude configured to electroporate the target tissue region, the second time period being less than the first time period. A third pulse is delivered without delay after the second pulse for a third time period, the third pulse having a third voltage amplitude being at least one from the group consisting of substantially the same as the first amplitude, larger than the first amplitude, and less than the first amplitude.

公开(公告)号：US12171484B2

公开(公告)日：2024-12-24

申请号：US17246766

申请日：2021-05-03

Applicant: Medtronic, Inc.

Inventor： Brian T. Howard ,  Mark T. Stewart ,  Lars M. Mattison

IPC: A61B18/14 ,  A61B18/00 ,  A61B18/12

Abstract: A medical device including a catheter having a proximal portion and a distal portion. A plurality of electrodes is disposed along the distal portion, the plurality of electrodes including a first electrode pair having a first fixed polarity and a second electrode pair having a second fixed polarity different than the first fixed polarity. A first lumen extends through the distal portion, the first lumen includes a first conductor configured to connect to a first electrode of the first electrode pair and a second conductor configured to connect to a second electrode of the first electrode pair. A second lumen extends through the distal portion and separated from the first lumen, the second lumen includes a third conductor configured to connect to a first electrode of the second electrode pair and a fourth conductor configured to connect to a second electrode of the second electrode pair.

公开(公告)号：US20240252225A1

公开(公告)日：2024-08-01

申请号：US18630713

申请日：2024-04-09

Applicant: Medtronic, Inc.

Inventor： Steven J. Fraasch ,  Catherine R. Condie ,  Brian T. Howard ,  Louis Jacob ,  Paul S. Lam ,  Trenton J. Rehberger ,  Mark T. Stewart ,  Qin Zhang

IPC: A61B18/12 ,  A61B5/00 ,  A61B5/287 ,  A61B5/349 ,  A61B5/352 ,  A61B18/00 ,  A61B18/14 ,  A61B18/16 ,  A61N1/30 ,  H02H1/00 ,  H02H3/16

CPC classification number: A61B18/1233 ,  A61B5/287 ,  A61B5/349 ,  A61B5/352 ,  A61B5/746 ,  A61B18/1492 ,  A61N1/303 ,  H02H1/0007 ,  H02H3/16 ,  A61B2018/0016 ,  A61B2018/00166 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00511 ,  A61B2018/00541 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00654 ,  A61B2018/00666 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00898 ,  A61B2018/126 ,  A61B2018/1266 ,  A61B2018/1407 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B18/16

Abstract: A system and method for the safe delivery of treatment energy to a patient, which includes verification of system integrity before, during, or after the delivery of treatment energy and provides several mechanisms for rapid termination of the delivery of potentially harmful energy to the patient when a fault condition in the device and/or system is identified. The system may include an energy generator having processing circuitry to determine if there is a fault condition in the system and to automatically terminate a delivery of treatment energy when the processing circuitry determines there is a fault condition. The method may generally include performing a series of pre-checks, synchronizing a treatment energy delivery to the proper segment of the heart's depolarization pattern, configuring the system for treatment energy delivery, delivering the treatment energy, and performing post-treatment evaluation.

公开(公告)号：US20230355301A1

公开(公告)日：2023-11-09

申请号：US18298731

申请日：2023-04-11

Applicant: Medtronic, Inc.

Inventor： Mary A. Beckman ,  Heather L. O'Connell ,  Timothy G. Laske ,  Mark T. Stewart ,  Brian T. Howard ,  Lars M. Mattison ,  Megan M. Schmidt ,  Sarah E. Ahlberg

IPC: A61B18/14

CPC classification number: A61B18/1492 ,  A61B2018/00577

Abstract: An example system for use in ablating target tissue includes memory configured to store anatomical and/or physiological information of a patient and processing circuitry communicatively coupled to the memory. The processing circuitry is configured to, based on the anatomical information and/or the physiological information, determine ablation parameters, the ablation parameters including a suggested positioning of at least energy delivery element of at least one catheter and/or an amount of energy to be delivered via the at least one energy delivery element to the target tissue during ablation. The processing circuitry is configured to output, for display, a representation of at least one of a suggested positioning of the at least one energy delivery element during the ablation, a representation of the target tissue, or a representation of the predicted tissue volume that will be ablated after delivery of ablation energy.

公开(公告)号：US11318306B2

公开(公告)日：2022-05-03

申请号：US16573181

申请日：2019-09-17

Applicant: Medtronic, Inc.

Inventor： Mark T. Stewart ,  Brian T. Howard

IPC: A61N1/32 ,  A61N1/30 ,  A61B18/14 ,  A61N1/378 ,  A61N1/05 ,  A61B18/00 ,  A61B18/12 ,  A61B18/02 ,  A61B17/00

Abstract: A method, system, and device for electroporation. A system may include a medical device with a plurality of electrodes borne on an expandable element and an energy generator in communication with the electrodes. The energy generator may have processing circuitry configured to selectively deliver electroporation energy to at least one of the electrodes. The processing circuitry may determine whether an alert condition is present and, if so, cease the delivery of electroporation energy to one or more electrodes identified as the cause of the alert condition and/or prevent the delivery of electroporation energy to the one or more electrodes identified as the cause of the alert condition. The energy generator may also be configured to deliver electroporation energy in a sequence of a plurality of energy delivery patterns to enhance lesion formation.

公开(公告)号：US20210038283A1

公开(公告)日：2021-02-11

申请号：US17078367

申请日：2020-10-23

Applicant: Medtronic, Inc.

Inventor： Steven J. Fraasch ,  Catherine R. Condie ,  Brian T. Howard ,  Louis Jacob ,  Paul S. Lam ,  Trenton J. Rehberger ,  Mark T. Stewart ,  Qin Zhang

IPC: A61B18/12 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/00 ,  A61B18/14 ,  A61N1/30 ,  H02H1/00 ,  H02H3/16

Abstract: A system and method for the safe delivery of treatment energy to a patient, which includes verification of system integrity before, during, or after the delivery of treatment energy and provides several mechanisms for rapid termination of the delivery of potentially harmful energy to the patient when a fault condition in the device and/or system is identified. The system may include an energy generator having processing circuitry to determine if there is a fault condition in the system and to automatically terminate a delivery of treatment energy when the processing circuitry determines there is a fault condition. The method may generally include performing a series of pre-checks, synchronizing a treatment energy delivery to the proper segment of the heart's depolarization pattern, configuring the system for treatment energy delivery, delivering the treatment energy, and performing post-treatment evaluation.

公开(公告)号：US20250049492A1

公开(公告)日：2025-02-13

申请号：US18928364

申请日：2024-10-28

Applicant: Medtronic, Inc.

Inventor： Mark T. Stewart ,  Brian T. Howard

IPC: A61B18/12 ,  A61B18/00 ,  A61B18/14

Abstract: Devices, systems, and methods for more efficiently ablating tissue with pulsed field ablation energy while minimizing collateral injury to non-target tissue. In one embodiment, a system for ablating tissue at a treatment site comprises: an energy delivery device; and a control unit including: a source of impedance-modifying fluid in fluid communication with the energy delivery device; an energy generator in electrical communication with the energy delivery device, the energy generator being configured to transmit energy to the energy delivery device and the energy delivery device being configured to deliver energy to the treatment site; and processing circuitry configured to control delivery of the impedance-modifying fluid from the energy delivery device to the treatment site. In one embodiment, a method for ablating tissue comprises delivering an impedance-modifying fluid to a treatment site and delivering pulsed field ablation energy to the treatment site.