公开(公告)号：US20090098097A1

公开(公告)日：2009-04-16

申请号：US12162091

申请日：2007-01-25

申请人： Toshinori Ikehara ,  Kenji Fujii ,  Kiyoshi Temmaru ,  Mikio Kitahara ,  Naoki Fukutomi

发明人： Toshinori Ikehara ,  Kenji Fujii ,  Kiyoshi Temmaru ,  Mikio Kitahara ,  Naoki Fukutomi

IPC分类号： A61K38/43 ,  A61K31/09 ,  A61K31/122 ,  A61P9/00

CPC分类号： A61K31/09 ,  A61K31/122

摘要： The present invention aims to provide a composition suitable for normalizing the blood pressure, which is useful as food, health food, supplement, nutritional supplement, food for specified health uses, food with nutrient function claims, pharmaceutical product, quasi-drug, feed or pet food.The present inventors have found that coenzyme Q has a superior effect for normalizing the blood pressure and completed the present invention. That is, the present invention provides a composition for normalizing the blood pressure, which contains reduced coenzyme Q as an active ingredient, and a composition for normalizing the blood pressure, which contains oxidized coenzyme Q as an active ingredient and improves hypotension.

摘要翻译： 本发明的目的是提供一种适用于使血压正常化的组合物，其可用作食品，保健食品，补充剂，营养补充剂，用于特定健康用途的食品，具有营养功能要求的食品，药物产品，准药物，饲料或 宠物食品。 本发明人发现辅酶Q具有优异的血压正常化效果，完成了本发明。 也就是说，本发明提供了含有还原型辅酶Q作为活性成分的血压正常化用组合物和含有氧化型辅酶Q作为有效成分的血压正常化组合物，能够改善低血压。

公开(公告)号：US07166311B2

公开(公告)日：2007-01-23

申请号：US10508903

申请日：2003-04-04

申请人： Toshinori Ikehara ,  Mikio Kitahara

发明人： Toshinori Ikehara ,  Mikio Kitahara

IPC分类号： A61K36/48

CPC分类号： A61K36/484 ,  A23L27/11 ,  A23L33/105 ,  A23L33/12 ,  A61K2300/00

摘要： In the present invention, an oil and fat composition containing 10% by weight or more of a specific fat-soluble polyhydric fatty acid ester, in particular, a glycerol fatty acid ester, is used as a solvent for extracting hydrophobic components from licorice. Consequently, it is possible to reduce the production costs for hydrophobic components of licorice which have excellent effects as food and drink, such as health food and food with health claims (food for specified health uses and food with nutrient function claims), pharmaceutical products, etc. It is also possible to improve the stability and handling properties of the resulting composition.

摘要翻译： 在本发明中，使用含有10重量％以上的特定脂溶性多元脂肪酸酯，特别是甘油脂肪酸酯的油脂组合物作为从甘草中提取疏水性成分的溶剂。 因此，可以降低作为食品和饮料具有优异效果的甘草疏水组分的生产成本，例如保健食品和具有健康要求的食品（具体的健康用途的食品和具有营养功能要求的食品），药品， 还可以提高所得组合物的稳定性和操作性能。

公开(公告)号：US07090874B2

公开(公告)日：2006-08-15

申请号：US10752643

申请日：2004-01-08

申请人： Tatsumasa Mae ,  Misuzu Tsukagawa ,  Hideyuki Kishida ,  Mitsuaki Kitano ,  Mikio Kitahara ,  Kaku Nakagawa ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

发明人： Tatsumasa Mae ,  Misuzu Tsukagawa ,  Hideyuki Kishida ,  Mitsuaki Kitano ,  Mikio Kitahara ,  Kaku Nakagawa ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

IPC分类号： A61K36/9066

CPC分类号： A61K31/12 ,  A21D2/14 ,  A23D7/0056 ,  A23D9/007 ,  A23K20/111 ,  A23K50/40 ,  A23L7/109 ,  A23L27/60 ,  A23L33/105 ,  A61K31/00

摘要： The object of the present invention is to provide PPARγ ligand derived from naturally occurring sources and a composition for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity comprising the PPARγ ligand as an active agent.The present invention relates to a ligand for peroxisome proliferator-activated receptor which comprises curcumin or its derivatives. The composition according to the present invention, which comprises the PPARγ ligand as an active agent is useful for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity.

公开(公告)号：US06281229B1

公开(公告)日：2001-08-28

申请号：US09446286

申请日：2000-03-27

申请人： Shin-ichi Yokota ,  Kozo Yamamoto ,  Souichi Morikawa ,  Yoshihide Fuse ,  Mikio Kitahara

发明人： Shin-ichi Yokota ,  Kozo Yamamoto ,  Souichi Morikawa ,  Yoshihide Fuse ,  Mikio Kitahara

IPC分类号： A61K31445

CPC分类号： C07D405/06

摘要： A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.

摘要翻译： 通过控制由热休克因子诱导的蛋白质的表达来提供疾病治疗。新化合物苯并-1,3-二氧杂环戊烷提供HSF活性的抑制剂或诱导由HSF调节的蛋白质的产生的抑制剂，其中 抑制热休克因子的活性，转录调节因子，从而进一步抑制基因区域中具有热休克元件序列的结构基因的转录，用于转录调节成RNA，从而抑制基因转化为蛋白质， 并导致抑制由该基因编码的RNA或蛋白质的产生。 它还提供通过热疗治疗或预防癌症的药物和用于治疗或预防压力疾病如抑郁症的药物。