公开(公告)号：US10556018B2

公开(公告)日：2020-02-11

申请号：US15674107

申请日：2017-08-10

Applicant: ModernaTX, Inc.

Inventor： Gilles Besin ,  Stephen Hoge ,  Joseph Senn ,  Kerry Benenato ,  Staci Sabnis

IPC: A61K48/00 ,  A61K9/127 ,  C12N15/88 ,  A61K47/54 ,  A61K47/69 ,  A61K47/60 ,  A61K31/713 ,  A61K39/39 ,  A61K47/10 ,  C08G65/332 ,  C08G65/333 ,  C08G65/334 ,  C08G65/335 ,  C12N15/117 ,  A61K31/7115 ,  A61K47/14 ,  A61K47/18 ,  A61K39/00

Abstract: This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

公开(公告)号：US09925277B2

公开(公告)日：2018-03-27

申请号：US15021287

申请日：2014-09-12

Applicant: ModernaTX, Inc.

Inventor： Örn Almarsson ,  Noubar B. Afeyan ,  Joseph Beene Bolen ,  Staci Sabnis

IPC: A61K48/00 ,  A61K31/198 ,  A61K38/00 ,  A61K9/00 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172

CPC classification number: A61K48/0066 ,  A61K9/0019 ,  A61K31/198 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172 ,  A61K38/00

Abstract: The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides formulations containing amino acids.