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21.
公开(公告)号:US20090209611A1
公开(公告)日:2009-08-20
申请号:US12383721
申请日:2009-03-25
Applicant: Revital Lifshitz-Liron , Tamas Koltai , Judith Aronhime , Nurit Perlman , Sharon Avhar-Maydan
Inventor: Revital Lifshitz-Liron , Tamas Koltai , Judith Aronhime , Nurit Perlman , Sharon Avhar-Maydan
IPC: A61K31/404 , C07D209/12 , A61P3/06
CPC classification number: C07D209/12 , C07D209/24
Abstract: Provided are crystalline forms of fluvastatin sodium and processes for their preparation.
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22.Polymorphic forms of ramelteon and processes for preparation thereof 审中-公开
Title translation: 苎麻的多形态及其制备方法公开(公告)号:US20090105490A1
公开(公告)日:2009-04-23
申请号:US12218369
申请日:2008-07-14
Applicant: Nurit Perlman , Michal Rafilovich , Rinat Moshkovits-Kaptsan , Elena Ben Moha-Lerman , Revital Lifshitz-Liron
Inventor: Nurit Perlman , Michal Rafilovich , Rinat Moshkovits-Kaptsan , Elena Ben Moha-Lerman , Revital Lifshitz-Liron
IPC: C07D307/77
CPC classification number: C07D307/77
Abstract: An amorphous form of ramelteon is provided, as well as mixtures of amorphous and crystalline ramelteon. Also provided are methods of preparing amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, pharmaceutical compositions comprising amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, and methods of treatment of insomnia using the compositions of the invention.
Abstract translation: 提供了无定形形式的拉面,以及无定形和结晶拉米尔顿的混合物。 还提供了制备无定形拉米尔顿的方法以及无定形和结晶拉米尔顿的混合物,包含无定形拉米尔顿的药物组合物和无定形和结晶拉米尔顿的混合物的方法,以及使用本发明的组合物治疗失眠的方法。
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公开(公告)号:US20090099365A1
公开(公告)日:2009-04-16
申请号:US12218401
申请日:2008-07-14
Applicant: Nurit Perlman , Gideon Pilarski
Inventor: Nurit Perlman , Gideon Pilarski
IPC: C07D453/04
CPC classification number: C07D453/02
Abstract: Processes for preparing solifenacin comprising distilling ethanol and organic solvent from a reaction mixture and recycling the organic solvent are described. Also described are processes for reducing solifenacin diastereomeric and enantiomeric impurities.
Abstract translation: 描述了制备索非那新的方法,其包括从反应混合物中蒸馏出乙醇和有机溶剂并回收有机溶剂。 还描述了降低索非那新非对映体和对映异构体杂质的方法。
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24.Process for preparing intermediates of ezetimibe by microbial reduction 审中-公开
Title translation: 通过微生物降解制备依泽麦布的中间体的方法公开(公告)号:US20090093627A1
公开(公告)日:2009-04-09
申请号:US12231438
申请日:2008-09-02
Applicant: Lorand Szabo , Laszlo Toth , Nurit Perlman
Inventor: Lorand Szabo , Laszlo Toth , Nurit Perlman
IPC: C07D205/08 , C12P17/10
CPC classification number: C12P17/10
Abstract: Processes of preparing an ezetimibe intermediate by microbial reduction and further converting the intermediate to ezetimibe are provided. Also provided is an ezetimibe intermediate with high diastereomeric excess.
Abstract translation: 提供了通过微生物还原制备依泽替米贝中间体并进一步将中间体转化为依泽替米贝的方法。 还提供了具有高非对映异构体过量的依泽替米贝中间体。
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25.Fluvastatin sodium crystal forms, processes for preparing them, compositions containing them and methods of using them 失效
Title translation: 氟伐他汀钠晶体形式,其制备方法,含有它们的组合物和使用它们的方法公开(公告)号:US07687642B2
公开(公告)日:2010-03-30
申请号:US11699659
申请日:2007-01-29
Applicant: Revital Lifshitz-Liron , Tamas Koltai , Judith Aronhime , Nurit Perlman , Sharon Avhar-Maydan
Inventor: Revital Lifshitz-Liron , Tamas Koltai , Judith Aronhime , Nurit Perlman , Sharon Avhar-Maydan
IPC: C07D209/12
CPC classification number: C07D209/12 , C07D209/24
Abstract: Provided are crystalline forms of fluvastatin sodium and processes for their preparation.
Abstract translation: 提供氟伐他汀钠的结晶形式及其制备方法。
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26.Fluvastatin sodium crystal forms, processes for preparing them, compositions containing them and methods of using them 审中-公开
Title translation: 氟伐他汀钠晶体形式,其制备方法,含有它们的组合物和使用它们的方法公开(公告)号:US20090118518A1
公开(公告)日:2009-05-07
申请号:US12150949
申请日:2008-04-30
Applicant: Revital Lifshitz-Liron , Tamas Koltai , Judith Aronhime , Nurit Perlman , Sharon Avhar-Maydan
Inventor: Revital Lifshitz-Liron , Tamas Koltai , Judith Aronhime , Nurit Perlman , Sharon Avhar-Maydan
IPC: C07D209/04
CPC classification number: C07D209/12 , C07D209/24
Abstract: Provided are crystalline forms of fluvastatin sodium and processes for their preparation.
Abstract translation: 提供氟伐他汀钠的结晶形式及其制备方法。
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27.Fluvastatin sodium crystal forms, processes for preparing them, compositions containing them and methods of using them 失效
Title translation: 氟伐他汀钠晶体形式,其制备方法,含有它们的组合物和使用它们的方法公开(公告)号:US07414140B2
公开(公告)日:2008-08-19
申请号:US10872089
申请日:2004-06-18
Applicant: Revital Lifshitz-Liron , Tamas Koltai , Judith Aronhime , Nurit Perlman , Sharon Avhar-Maydan
Inventor: Revital Lifshitz-Liron , Tamas Koltai , Judith Aronhime , Nurit Perlman , Sharon Avhar-Maydan
IPC: C07D209/12
CPC classification number: C07D209/12 , C07D209/24
Abstract: Provided are polymorphic forms of fluvastatin sodium and processes for their preparation.
Abstract translation: 提供氟伐他汀钠的多晶型物质及其制备方法。
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公开(公告)号:US20080114171A1
公开(公告)日:2008-05-15
申请号:US11890316
申请日:2007-08-03
Applicant: Tamas Koltai , Nurit Perlman , Tamar Nidam , Mili Abramov
Inventor: Tamas Koltai , Nurit Perlman , Tamar Nidam , Mili Abramov
IPC: C07D453/02 , A61P13/10
CPC classification number: C07D453/02 , C07D217/02
Abstract: Polymorphic forms of solifenacin base have been prepared and characterized. These polymorphic forms are particularly useful for preparing solifenacin salts.
Abstract translation: 已经制备和表征索非那新碱的多晶型。 这些多晶型对于制备索非那新盐特别有用。
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公开(公告)号:US20080114029A1
公开(公告)日:2008-05-15
申请号:US11890264
申请日:2007-08-03
Applicant: Tamas Koltai , Nurit Perlman , Tamar Nidam , Dov Diller
Inventor: Tamas Koltai , Nurit Perlman , Tamar Nidam , Dov Diller
IPC: A61K31/47 , C07D217/02
CPC classification number: C07D453/02 , C07D217/02
Abstract: Polymorphic forms of 1(S)-phenyl-1,2,3,4-tetrahydroisoquinoline have been prepared and characterized. These polymorphic forms are particularly useful for preparing solifenacin salts.
Abstract translation: 已经制备并表征了1(S) - 苯基-1,2,3,4-四氢异喹啉的多晶型。 这些多晶型对于制备索非那新盐特别有用。
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公开(公告)号:US20070173528A1
公开(公告)日:2007-07-26
申请号:US11645021
申请日:2006-12-21
Applicant: Nurit Perlman , Tamar Nidam
Inventor: Nurit Perlman , Tamar Nidam
IPC: A61K31/4745 , A61K31/47 , C07D453/02 , C07D217/02
CPC classification number: C07D217/06 , C07D453/02
Abstract: Provided are new intermediates of solifenacin and methods for their preparation, as well as methods of preparing solifenacin and solifenacin succinate.
Abstract translation: 提供索非那新的新中间体及其制备方法,以及制备索非那新和索非那新琥珀酸酯的方法。
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