公开(公告)号：US09513219B2

公开(公告)日：2016-12-06

申请号：US14058907

申请日：2013-10-21

Applicant: OLYMPUS CORPORATION

Inventor： Yasushige Ishihara

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04

CPC classification number: G01N21/64 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/00096 ,  A61B1/043

Abstract: Provided is a fluoroscopy apparatus including illuminating portions that radiate excitation light and illumination light onto an imaging subject; a fluorescence imaging portion that acquires a fluorescence image from fluorescence emitted at the imaging subject due to the irradiation with the excitation light; a return-light imaging portion that acquires a return-light image from return light returning from the imaging subject due to the irradiation with the illumination light; a display portion that displays the acquired fluorescence image and/or the return-light image; an identifying portion that identifies a region-of-interest in the fluorescence image; an image switching portion that switches the display on the display portion so that only the return-light image is displayed thereon when the region-of-interest R is not identified, and so that the return-light image and the fluorescence image are juxtaposed and displayed on the display portion when the region-of-interest has been identified.

Abstract translation: 本发明提供一种荧光透视设备，其包括将激发光和照明光辐射到成像对象上的照明部分; 荧光成像部，其由于激发光的照射而从成像对象发射的荧光获取荧光图像; 返回光成像部，其从由所述照明光的照射而从所述摄像对象返回的返回光获取返回光图像; 显示所获取的荧光图像和/或返回光图像的显示部分; 标识部分，其识别所述荧光图像中的感兴趣区域; 图像切换部，其在显示部切换显示部，使得当没有识别出感兴趣区域R时仅显示返回光图像，并且使得返回光图像和荧光图像并置，并且 当识别出感兴趣区域时，显示在显示部分上。

公开(公告)号：US09241139B2

公开(公告)日：2016-01-19

申请号：US13956447

申请日：2013-08-01

Applicant: OLYMPUS CORPORATION

Inventor： Yasushige Ishihara

IPC: H04N7/18 ,  A61B1/04 ,  G01N21/64 ,  A61B1/00 ,  A61B1/045 ,  H04N5/225

CPC classification number: H04N7/18 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/045 ,  G01N21/6456 ,  G01N2021/6484 ,  H04N2005/2255

Abstract: Observation is performed at a more appropriate sensitivity without reducing an image quality. Provided is a fluorescence observation device (1) including: an excitation light source (3) that emits excitation light to be radiated onto a subject (A); a fluorescence-image acquiring section (21) provided with an imaging element (18) that acquires a fluorescence image (G2) by imaging fluorescence produced in the subject (A) when the excitation light emitted from the excitation light source (3) is radiated onto the subject (A); and a sensitivity adjusting section (22) that adjusts, based on luminance information of the fluorescence image (G2) acquired by the imaging element (18) of the fluorescence-image acquiring section (21), a number of pixels for binning summing (B) and/or an exposure time (t) in the imaging element (18) such that a SN ratio of the fluorescence image (G2) is equal to or larger than a predetermined threshold.

Abstract translation: 以更合适的灵敏度进行观察，而不会降低图像质量。 本发明提供一种荧光观察装置（1），其特征在于，包括：发射被照射到被检体（A）上的激发光的激发光源（3）。 荧光图像获取部分（21）具有成像元件（18），当从激发光源（3）发出的激发光被照射时，成像元件（18）通过成像对象（A）中产生的荧光来获取荧光图像（G2） （A）; 以及灵敏度调整部（22），其基于由所述荧光图像获取部（21）的摄像元件（18）获取的荧光图像（G2）的亮度信息，调整用于合并求和的像素数（B ）和/或成像元件（18）中的曝光时间（t），使得荧光图像（G2）的SN比等于或大于预定阈值。

公开(公告)号：US09182347B2

公开(公告)日：2015-11-10

申请号：US14173202

申请日：2014-02-05

Applicant: OLYMPUS CORPORATION

Inventor： Yasushige Ishihara

IPC: G06K9/40 ,  G01N21/64 ,  A61B1/04 ,  A61B1/06 ,  G02B23/24 ,  A61B1/00 ,  G06T5/00

CPC classification number: G01N21/64 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  G02B23/2461 ,  G06T5/009

Abstract: A fluoroscopy apparatus includes a preprocessing section that multiplies at least one of a fluorescence image and a reference-light image by a coefficient by which distance characteristics of fluorescence intensity and distance characteristics of return-light intensity acquired from a standard sample in advance are made directly proportional to each other to generate a correction fluorescence image and a correction reference-light image; a divided-image generating section that divides the correction fluorescence image by the correction reference-light image to generate a divided image; a threshold-setting section that sets a threshold based on a mean grayscale level of pixels in the divided image; an image-adjusting section that enhances contrast between a region with grayscale levels above the set threshold set by the threshold-setting section and a region with grayscale levels below the threshold in the divided image; and a monitor that displays the divided image with the enhanced contrast.

Abstract translation: 荧光透视设备包括：预处理部分，其将荧光图像和参考光图像中的至少一个乘以直接从标准样品获取的荧光强度和返回光强度的距离特性的距离特性和距离特性的系数 彼此成比例地产生校正荧光图像和校正参考光图像; 分割图像生成部，其将校正用荧光图像除以校正基准光图像，生成分割图像; 阈值设定部，其基于分割图像中的像素的平均灰度级设定阈值; 图像调整部，其增强在阈值设定部设定的设定阈值以上的灰度等级的区域与分割图像的灰度级低于阈值的区域之间的对比度; 以及显示器，其显示具有增强的对比度的分割图像。

公开(公告)号：US08831374B2

公开(公告)日：2014-09-09

申请号：US13834549

申请日：2013-03-15

Applicant: Olympus Corporation

Inventor： Toshiaki Watanabe ,  Yasushige Ishihara

IPC: G06K9/00 ,  G01N21/64 ,  A61B1/06 ,  A61B1/04 ,  H04N5/235 ,  G06T5/00 ,  A61B5/00

CPC classification number: G01N21/64 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B5/0071 ,  A61B5/0084 ,  G01N21/6454 ,  G01N21/6456 ,  G01N21/6486 ,  G06T5/009 ,  H04N5/2351

Abstract: A fluoroscopy apparatus including: an illumination unit having a light source radiating illumination light and excitation light onto an observation target, a fluorescence-imaging unit acquiring a fluorescence image by imaging fluorescence generated at the observation target by the excitation light, a white-light-imaging unit acquiring a reference image by imaging light returning from the observation target by the illumination light, and an image-correction unit obtaining a correction fluorescence image by raising the luminance value of the fluorescence image to the power of a reciprocal of a first and second exponent obtained by a power approximation of a distance characteristic of luminance versus observation distance, for the fluorescence image, and that obtains a corrected fluorescence image by dividing the correction fluorescence image by the correction reference image.

公开(公告)号：US08682096B2

公开(公告)日：2014-03-25

申请号：US13834725

申请日：2013-03-15

Applicant: Olympus Corporation

Inventor： Toshiaki Watanabe ,  Yasushige Ishihara

IPC: G06K9/00

CPC classification number: G01N21/64 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B5/0071 ,  A61B5/0084 ,  G01N21/6454 ,  G01N21/6456 ,  G01N21/6486 ,  G06T5/009 ,  H04N5/2351

Abstract: A fluoroscopy apparatus including: an illumination unit having a light source radiating illumination light and excitation light onto an observation target, a fluorescence-imaging unit acquiring a fluorescence image by imaging fluorescence generated at the observation target by the excitation light, a white-light-imaging unit acquiring a reference image by imaging light returning from the observation target by the illumination light, and an image-correction unit obtaining a correction fluorescence image by raising the luminance value of the fluorescence image to the power of a reciprocal of a first and second exponent obtained by a power approximation of a distance characteristic of luminance versus observation distance, for the fluorescence image, and that obtains a corrected fluorescence image by dividing the correction fluorescence image by the correction reference image.

Abstract translation: 一种荧光透视设备，包括：照明单元，其具有将观察对象上产生的荧光通过激发光成像的荧光图像获取荧光图像的荧光照射光和激发光的光源发射到观察对象物上;荧光成像单元， 成像单元通过对通过照明光从观察目标返回的光成像获取参考图像;以及图像校正单元，通过将荧光图像的亮度值提高到第一和第二的倒数的幂来获得校正荧光图像 通过对荧光图像的亮度与观察距离的距离特性的功率近似获得的指数，并且通过将校正荧光图像除以校正参考图像获得校正的荧光图像。