公开(公告)号：US09737636B2

公开(公告)日：2017-08-22

申请号：US14844259

申请日：2015-09-03

Applicant: TERUMO KABUSHIKI KAISHA ,  OSAKA UNIVERSITY

Inventor： Fumiya Oohashi ,  Ryouhei Takeuchi ,  Tadashi Sameshima ,  Shigeru Miyagawa ,  Yoshiki Sawa ,  Atsuhiro Saito

IPC: A61L27/34 ,  A61L27/38 ,  A61L27/58 ,  A61L27/22 ,  A61L27/52

CPC classification number: A61L27/58 ,  A61L27/225 ,  A61L27/38 ,  A61L27/52 ,  A61L2430/20

Abstract: A laminate of a sheet-shaped cell culture is disclosed, which has excellent operability and is suitable for implantation. A method is disclosed for producing a laminate of a fibrin gel and a sheet-shaped cell culture, including a step of dripping a liquid containing fibrinogen onto an upper surface of a sheet-shaped cell culture, a step of spraying a liquid containing thrombin onto the surface, and a step of forming a fibrin gel layer on the surface by a reaction between fibrinogen and thrombin; and a laminate of a fibrin gel and a sheet-shaped cell culture produced by the method are disclosed.

公开(公告)号：US20160250395A1

公开(公告)日：2016-09-01

申请号：US15028803

申请日：2014-09-10

Applicant: ONO PHARMACEUTICAL CO., LTD. ,  OSAKA UNIVERSITY

Inventor： Yoshiki Sawa ,  Toru Kuratani ,  Koichi Toda ,  Takayoshi Ueno ,  Shigeru Miyagawa ,  Satsuki Fukushima ,  Atsuhiro Saito ,  Yoshiki Watanabe ,  Yoshiki Sakai

IPC: A61L31/16 ,  A61F2/07 ,  A61L31/14 ,  A61F2/82

CPC classification number: A61L31/16 ,  A61F2/07 ,  A61F2/82 ,  A61F2240/001 ,  A61F2250/0067 ,  A61F2310/0097 ,  A61K9/0024 ,  A61K31/343 ,  A61K31/4406 ,  A61K31/5585 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  A61L31/148 ,  A61L2300/412 ,  A61L2300/602

Abstract: The present invention provides a drug-eluting stent graft for preventing stent graft-related complications as well as treating aneurysm. Specifically, the present invention relates to a drug-eluting stent graft comprising a drug, a drug-retaining agent and a stent graft, and a method for therapy of aneurysm including the use of the drug-eluting stent graft.

Abstract translation: 本发明提供了用于预防支架移植物相关并发症以及治疗动脉瘤的药物洗脱支架移植物。 具体而言，本发明涉及包含药物，药物保留剂和支架移植物的药物洗脱支架移植物，以及包括使用药物洗脱支架移植物的动脉瘤治疗方法。

公开(公告)号：US20150273017A1

公开(公告)日：2015-10-01

申请号：US14436906

申请日：2013-10-24

Applicant: GENOMIX CO., LTD. ,  OSAKA UNIVERSITY

Inventor： Katsuto Tamai ,  Sokichi Kamata ,  Yasufumi Kaneda ,  Shigeru Miyagawa ,  Yoshiki Sawa ,  Takehiko Yamazaki

IPC: A61K38/17

CPC classification number: A61K38/1709 ,  C07K14/4718

Abstract: A fragment peptide having a proper length composed of a part of an HMGB1 protein was synthesized and the peptide was confirmed to exhibit therapeutic effects on myocardial infarction.

Abstract translation: 合成具有由HMGB1蛋白的一部分组成的适当长度的片段肽，并确认该肽对心肌梗死具有治疗效果。