公开(公告)号：US20190284216A1

公开(公告)日：2019-09-19

申请号：US16297910

申请日：2019-03-11

Applicant: PFIZER INC.

Inventor： Martin James Wythes ,  Indrawan James McAlpine ,  Ryan Patman ,  Eugene Yuanjin Rui ,  Andrew Fensome ,  Andreas Maderna ,  Mehran Jalaie ,  Ketan S. Gajiwala

IPC: C07F9/6574 ,  A61P35/00 ,  A61K47/68

Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US20180044344A1

公开(公告)日：2018-02-15

申请号：US15664265

申请日：2017-07-31

Applicant: Pfizer Inc.

Inventor： Douglas Carl Behenna ,  Ping Chen ,  Kevin Daniel Freeman-Cook ,  Robert Louis Hoffman ,  Mehran Jalaie ,  Asako Nagata ,  Sajiv Krishnan Nair ,  Sacha Ninkovic ,  Martha Alicia Ornelas ,  Cynthia Louise Palmer ,  Eugene Yuanjin Rui

IPC: C07D487/04 ,  C07D401/14

CPC classification number: C07D487/04 ,  C07D401/14 ,  C07D471/04

Abstract: This invention relates to compounds of general Formula (I) and pharmaceutically acceptable salts thereof, in which R1, R2, R2A, R2B, R3, R4, R5A, R5B, R6, R7, R8, R9, p, q and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

公开(公告)号：US20170015689A1

公开(公告)日：2017-01-19

申请号：US15209574

申请日：2016-07-13

Applicant: PFIZER INC.

Inventor： Ping Chen ,  Hengmiao CHENG ,  Gary Michael Gallego ,  Mehran Jalaie ,  John Charles Kath ,  Suvi Tuula Marjukka Orr ,  Mason Alan PAIRISH

IPC: C07F9/6558 ,  C07D401/14 ,  C07D413/14 ,  C07D403/14

CPC classification number: C07F9/65583 ,  A61K31/5377 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1-R11, m, n, and p are defined herein. The novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract translation: 或其药学上可接受的盐，其中X，Y，Z，R 1 -R 11，m，n和p在本文中定义。 新型嘧啶衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 另外的实施方案涉及含有化合物的药物组合物和使用化合物和组合物治疗哺乳动物异常细胞生长的方法。