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公开(公告)号：US07041197B2
公开(公告)日：2006-05-09
申请号：US10413693
申请日：2003-04-15
申请人： Bruce J. Kokko , David W. White
发明人： Bruce J. Kokko , David W. White
IPC分类号： D21H17/43
CPC分类号： D21H23/765 , C08F8/32 , C08F8/44 , D21H17/43 , D21H17/64 , D21H17/71 , D21H21/22 , C08F210/02 , C08F222/06
摘要： A method for making paper to enhance its wet strength includes adding separately to a cellulosic paper pulp furnish the following additives to form a treated pulp: a cationic wet strength resin whose cationic sites bond to anionic sites of cellulose fibers contained in the paper pulp furnish, and a hydrophobically modified anionic polyelectrolyte whose anionic sites bond with cationic sites of the cationic wet strength resin.
摘要翻译： 制造纸以提高其湿强度的方法包括分别加入到纤维素纸浆中，提供以下添加剂以形成经处理的纸浆：阳离子湿强度树脂，其阳离子位点与纸浆配料中包含的纤维素纤维的阴离子位点结合， 和疏水改性的阴离子聚电解质，其阴离子部位与阳离子湿强度树脂的阳离子部位键合。
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22.发明授权公开(公告)号：US06977240B1
公开(公告)日：2005-12-20
申请号：US09950149
申请日：2001-09-10
IPC分类号： A61K39/395 , C07K14/715
CPC分类号： C07K14/715 , C07K14/72 , C07K2319/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/044
摘要： The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.
摘要翻译： 本发明涉及编码参与哺乳动物体重调节的受体蛋白Ob受体（ObR）的核苷酸的发现，鉴定和表征。 本发明包括obR核苷酸，宿主细胞表达系统，ObR蛋白，融合蛋白，多肽和肽，受体抗体，表达obR转基因的转基因动物或不表达ObR的拮抗剂和激动剂的重组敲除动物 的受体和调节可用于诊断，药物筛选，临床试验监测和/或治疗体重障碍（包括但不限于肥胖，恶病质和厌食）的obR基因表达或ObR活性的其它化合物。
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公开(公告)号：US06287782B1
公开(公告)日：2001-09-11
申请号：US09069781
申请日：1998-04-29
IPC分类号： G01N3353
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.
摘要翻译： 本发明涉及编码参与哺乳动物体重调节的受体蛋白Ob受体（ObR）的核苷酸的发现，鉴定和表征。 本发明包括obR核苷酸，宿主细胞表达系统，ObR蛋白，融合蛋白，多肽和肽，受体抗体，表达obR转基因的转基因动物或不表达ObR的拮抗剂和激动剂的重组敲除动物 的受体和调节可用于诊断，药物筛选，临床试验监测和/或治疗体重障碍（包括但不限于肥胖，恶病质和厌食）的obR基因表达或ObR活性的其它化合物。
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公开(公告)号：US4869865A
公开(公告)日：1989-09-26
申请号：US279185
申请日：1988-12-02
IPC分类号： G21C3/34
CPC分类号： G21C3/3424 , Y02E30/40 , Y10T29/49829
摘要： In the automated production line manufacture of nuclear fuel bundle spacers, rod-supporting ferrules are cut from tubular stock, checked for length, laser cut to create predetermined features in the ferrule sidewall, formed with rod-centering stops in the ferrule sidewall, and checked for stop height dimensional accuracy. Pairs of ferrules are subassembled with a captive spring and assembled into a spacer assembly fixture together with other spacer parts. The fixtured spacer parts are conjoined by laser welding to create a structurally rigid spacer. The various production line operating stations are served by separate controllers linked to a central computer for production status reporting, parts traceability, and overall control purposes.
摘要翻译： 在核燃料束间隔物的自动化生产线生产线中，从管状坯料切割棒支撑套圈，检查长度，激光切割以在套圈侧壁中产生预定特征，在套圈侧壁中形成有杆定心止动件，并检查 用于停止高度尺寸精度。 一对套圈用固定弹簧组装，并与其他间隔件一起组装成间隔件组装夹具。 夹具的间隔件通过激光焊接结合在一起，形成结构刚性的间隔件。 各种生产线操作站由连接到中央计算机的单独控制器提供，用于生产状态报告，零件可追溯性和总体控制目的。
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25.发明授权公开(公告)号：US09382664B2
公开(公告)日：2016-07-05
申请号：US13343041
申请日：2012-01-04
CPC分类号： D21H21/146 , D21H21/14 , D21H25/005 , D21H27/002
摘要： Improvements to absorbent sheet manufacture include spraying a softener onto the web and providing a creping adhesive to a surface of a heated drying cylinder of a Yankee dryer such that a creping adhesive coating is formed, the creping adhesive comprising a poly(aminoamide)epihalohydrin (PAE) resin and a polyvinyl alcohol copolymer, wherein the polyvinyl alcohol copolymer includes functional repeat units selected from carboxylate repeat units, sulfonate repeat units as well as combinations of the comonomers. A preferred PAE resin is fully crosslinked PAE resin.
摘要翻译： 对吸收性片材制造的改进包括将柔软剂喷涂到网状物上并在扬克干燥器的加热干燥筒的表面上提供起皱粘合剂，使得形成起皱粘合剂涂层，起皱粘合剂包含聚（氨基酰胺）表卤代醇（PAE ）树脂和聚乙烯醇共聚物，其中聚乙烯醇共聚物包括选自羧酸酯重复单元，磺酸盐重复单元以及共聚单体的组合的官能重复单元。 优选的PAE树脂是完全交联的PAE树脂。
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26.发明申请METHOD OF MAKING A PAPER WEB HAVING A HIGH INTERNAL VOID VOLUME OF SECONDARY FIBERS 有权制造具有二次纤维的高内部空隙体积的纸网的方法公开(公告)号：US20100314059A1
公开(公告)日：2010-12-16
申请号：US12857865
申请日：2010-08-17
CPC分类号： D21F11/145 , D21F11/006 , D21F11/14 , Y10T428/24455
摘要： The present invention is a method of making a near-premium quality paper product having good strength and absorbency characteristics and a product made by that method. The invention is also a method for retaining a high ash content within a paper web formed by conventional wet pressing. The present invention is also a method for retaining a high percentage of softening agent within a paper web that includes such an agent. Further, the present invention is a soft absorbent paper product having a high void volume. Finally, the invention is also a method for producing a soft, absorbent, and near premium paper product having a high void volume using an undulatory crepe blade having a multiplicity of serrulations in its rake surface which presents differentiated creping angles and/or rake angles as to the paper being creped.
摘要翻译： 本发明是制造具有良好强度和吸收特性的近乎优质的纸制品的方法和由该方法制成的产品。 本发明还是一种通过常规湿法压制形成的纸幅中保持高灰分含量的方法。 本发明也是一种在包含这种试剂的纸幅内保持高百分比的软化剂的方法。 此外，本发明是具有高空隙体积的软吸收性纸制品。 最后，本发明也是一种用于生产具有高空隙体积的柔软的，吸收性的和接近优质的纸制品的方法，所述纸制品具有高的空隙体积，该波纹绉纱刀片在其前刀面上具有多个锯齿状，其具有不同的起伏角和/或前角， 纸张被起皱。
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公开(公告)号：US07328902B1
公开(公告)日：2008-02-12
申请号：US11282919
申请日：2005-11-18
申请人： David W. White , Shelley M. White
发明人： David W. White , Shelley M. White
IPC分类号： A63B67/00
CPC分类号： A63B67/06 , A63B43/007 , A63B63/00 , A63B63/06 , A63B69/0079 , A63B2067/063
摘要： A target apparatus for bola tossing games has both a forward and rearward frame presenting one or more rung-targets as well as a construction for the rung-targets by which such have free-spinning outer sleeves. Wherein the spacing between the forward and rearward changes the complexion of bola tossing games by adding a depth dimension among various ones of the rung-targets. And wherein the free-spinning aspect of the rung-targets increases the level of difficulty and skill in perching bolas, either wrapped or draped, at rest on rungs by not only increasing the propensity of landing bolas to, in quick succession, wind fully in and then on rebound unwind and thereafter self-launch off the subject rung but also by increasing the propensity that the foregoing dislodges any previously perched bola.
摘要翻译： 一种用于喷射游戏的目标装置具有呈现一个或多个梯级目标的前部和后部框架以及用于这些具有自由旋转外部套筒的梯级目标的构造。 其中前后的间距通过在梯级目标的各种之间添加深度维度来改变bola投掷游戏的肤色。 而且，梯级目标的自由旋转方面，通过不断增加降落弹药的倾向，可以快速地连续地将风力完全放在 然后在反弹放松，然后自主发射主题梯级，但也通过增加前述的倾向消除任何以前栖息的bola的倾向。
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28.发明授权Methods of identifying compounds that modulate body weight using the OB receptor 失效使用OB受体鉴定调节体重的化合物的方法公开(公告)号：US06395498B1
公开(公告)日：2002-05-28
申请号：US08864564
申请日：1997-05-28
IPC分类号： G01N3353
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.
摘要翻译： 本发明涉及编码参与哺乳动物体重调节的受体蛋白Ob受体（ObR）的核苷酸的发现，鉴定和表征。 本发明包括obR核苷酸，宿主细胞表达系统，ObR蛋白，融合蛋白，多肽和肽，受体抗体，表达obR转基因的转基因动物或不表达ObR的拮抗剂和激动剂的重组敲除动物 的受体和调节可用于诊断，药物筛选，临床试验监测和/或治疗体重障碍（包括但不限于肥胖，恶病质和厌食）的obR基因表达或ObR活性的其它化合物。
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公开(公告)号：US06380363B1
公开(公告)日：2002-04-30
申请号：US09137132
申请日：1998-08-19
IPC分类号： C07K1628
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.
摘要翻译： 本发明涉及编码参与哺乳动物体重调节的受体蛋白Ob受体（ObR）的核苷酸的发现，鉴定和表征。 本发明包括obR核苷酸，宿主细胞表达系统，ObR蛋白，融合蛋白，多肽和肽，受体抗体，表达obR转基因的转基因动物或不表达ObR的拮抗剂和激动剂的重组敲除动物 的受体和调节可用于诊断，药物筛选，临床试验监测和/或治疗体重障碍（包括但不限于肥胖，恶病质和厌食）的obR基因表达或ObR活性的其它化合物。
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公开(公告)号：US5727039A
公开(公告)日：1998-03-10
申请号：US616509
申请日：1996-03-19
申请人： John L. Harmon , Richard G. Patterson , Robert B. Elkins , Russell P. Higgins , Edward A. Croteau , Harold B. King , Christian D. Frederickson , Gerald M. Latter , Anthony P. Reese , David W. White
发明人： John L. Harmon , Richard G. Patterson , Robert B. Elkins , Russell P. Higgins , Edward A. Croteau , Harold B. King , Christian D. Frederickson , Gerald M. Latter , Anthony P. Reese , David W. White
CPC分类号： G21C3/332 , G21Y2002/302 , G21Y2002/304 , G21Y2004/301 , Y02E30/40
摘要： In a nuclear reactor fuel bundle assembly having a plurality of fuel rods and a non-round water rod extending between upper and lower tie plates, and having at least one fuel rod spacer located along the non-round water rod, an improvement which includes cooperating components on the fuel rod spacer and on the water rod for permitting movement of the spacer along the water rod to a desired axial location and for thereafter preventing further axial movement of the spacer in at least one of two opposite axial directions, the cooperating components including at least one spring on one of the spacer and the water rod.
摘要翻译： 在具有多个燃料棒和在上下连接板之间延伸的非圆形水杆的核反应堆燃料束组件中，并且具有沿着非圆形水棒定位的至少一个燃料棒间隔件，其包括配合 燃料棒间隔件和水杆上的部件，用于允许间隔件沿水杆移动到期望的轴向位置，并且此后防止间隔件在两个相对的轴向方向中的至少一个中的进一步的轴向运动，所述协作部件包括 在间隔件和水杆之一上的至少一个弹簧。
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