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1.发明授权Methods for detection of the Ob receptor and the diagnosis of body weight disorders, including obesity and cachexia 失效检测Ob受体的方法和体重障碍的诊断，包括肥胖症和恶病质公开(公告)号：US07547515B2
公开(公告)日：2009-06-16
申请号：US11202330
申请日：2005-08-11
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/567
CPC分类号： C07K14/715 , C07K14/72 , C07K2319/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/044
摘要： The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.
摘要翻译： 本发明涉及编码参与哺乳动物体重调节的受体蛋白Ob受体（ObR）的核苷酸的发现，鉴定和表征。 本发明包括obR核苷酸，宿主细胞表达系统，ObR蛋白，融合蛋白，多肽和肽，受体抗体，表达obR转基因的转基因动物或不表达ObR的拮抗剂和激动剂的重组敲除动物 的受体和调节可用于诊断，药物筛选，临床试验监测和/或治疗体重障碍（包括但不限于肥胖，恶病质和厌食）的obR基因表达或ObR活性的其它化合物。
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公开(公告)号：US10080876B2
公开(公告)日：2018-09-25
申请号：US13060040
申请日：2009-08-20
申请人： Robert I. Tepper , Russell Hirsch , Jason E. Fuller , Jessica L. Duda , Craig Muir , Jeffrey S. Ross , J. Christopher Flaherty
发明人： Robert I. Tepper , Russell Hirsch , Jason E. Fuller , Jessica L. Duda , Craig Muir , Jeffrey S. Ross , J. Christopher Flaherty
CPC分类号： A61M31/002 , A61B5/14532 , A61B5/1455 , A61B5/415 , A61B5/418 , A61B5/4839 , A61M37/0015 , A61M2037/0023 , A61M2037/0061
摘要： Described here are devices, systems, and kits for delivering substances to tissues. The devices generally include one or more chambers (102) and a reservoir (108) within each chamber. The reservoir may locally deliver a microdose amount of a substance to a target tissue. In some variations, a microdose amount is used in early human studies, e.g., before a phase I clinical trial, to evaluate the effect of the substance on a target tissue, or to obtain pharmacokinetic or metabolic data. In other variations, a microdose amount is used to locally treat a medical condition. In yet other variations, a microdose amount is used to locally deliver a contrast agent for a structural or functional imaging procedure. Methods for delivering and retrieving the devices from the target tissue are also described.
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公开(公告)号：US20110230736A1
公开(公告)日：2011-09-22
申请号：US13060040
申请日：2009-08-20
申请人： Robert I. Tepper , Russell Hirsch , Jason E. Fuller , Jessica L. Duda , Craig Muir , Jeffrey S. Ross , J. Christopher Flaherty
发明人： Robert I. Tepper , Russell Hirsch , Jason E. Fuller , Jessica L. Duda , Craig Muir , Jeffrey S. Ross , J. Christopher Flaherty
CPC分类号： A61M31/002 , A61B5/14532 , A61B5/1455 , A61B5/415 , A61B5/418 , A61B5/4839 , A61M37/0015 , A61M2037/0023 , A61M2037/0061
摘要： Described here are devices, systems, and kits for delivering substances to tissues. The devices generally include one or more chambers (102) and a reservoir (108) within each chamber. The reservoir may locally deliver a microdose amount of a substance to a target tissue. In some variations, a microdose amount is used in early human studies, e.g., before a phase I clinical trial, to evaluate the effect of the substance on a target tissue, or to obtain pharmacokinetic or metabolic data. In other variations, a microdose amount is used to locally treat a medical condition. In yet other variations, a microdose amount is used to locally deliver a contrast agent for a structural or functional imaging procedure. Methods for delivering and retrieving the devices from the target tissue are also described.
摘要翻译： 这里描述的是用于将物质输送到组织的装置，系统和试剂盒。 装置通常包括在每个室内的一个或多个室（102）和储存器（108）。 储存器可以局部地将微剂量的物质输送到靶组织。 在一些变化中，微量剂量用于早期人类研究，例如在I期临床试验之前，以评价该物质对靶组织的作用，或获得药代动力学或代谢数据。 在其他变型中，使用微量剂量来局部治疗医疗状况。 在其它变型中，使用微量的量来局部输送用于结构或功能成像过程的造影剂。 还描述了用于从靶组织递送和检索装置的方法。
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4.发明授权公开(公告)号：US06977240B1
公开(公告)日：2005-12-20
申请号：US09950149
申请日：2001-09-10
IPC分类号： A61K39/395 , C07K14/715
CPC分类号： C07K14/715 , C07K14/72 , C07K2319/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/044
摘要： The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.
摘要翻译： 本发明涉及编码参与哺乳动物体重调节的受体蛋白Ob受体（ObR）的核苷酸的发现，鉴定和表征。 本发明包括obR核苷酸，宿主细胞表达系统，ObR蛋白，融合蛋白，多肽和肽，受体抗体，表达obR转基因的转基因动物或不表达ObR的拮抗剂和激动剂的重组敲除动物 的受体和调节可用于诊断，药物筛选，临床试验监测和/或治疗体重障碍（包括但不限于肥胖，恶病质和厌食）的obR基因表达或ObR活性的其它化合物。
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公开(公告)号：US06287782B1
公开(公告)日：2001-09-11
申请号：US09069781
申请日：1998-04-29
IPC分类号： G01N3353
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.
摘要翻译： 本发明涉及编码参与哺乳动物体重调节的受体蛋白Ob受体（ObR）的核苷酸的发现，鉴定和表征。 本发明包括obR核苷酸，宿主细胞表达系统，ObR蛋白，融合蛋白，多肽和肽，受体抗体，表达obR转基因的转基因动物或不表达ObR的拮抗剂和激动剂的重组敲除动物 的受体和调节可用于诊断，药物筛选，临床试验监测和/或治疗体重障碍（包括但不限于肥胖，恶病质和厌食）的obR基因表达或ObR活性的其它化合物。
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6.发明授权公开(公告)号：US06482927B1
公开(公告)日：2002-11-19
申请号：US08708123
申请日：1996-09-03
IPC分类号： C12P2108
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.
摘要翻译： 本发明涉及编码参与哺乳动物体重调节的受体蛋白Ob受体（ObR）的核苷酸的发现，鉴定和表征。 本发明包括obR核苷酸，宿主细胞表达系统，ObR蛋白，融合蛋白，多肽和肽，受体抗体，表达obR转基因的转基因动物或不表达ObR的拮抗剂和激动剂的重组敲除动物 的受体和调节可用于诊断，药物筛选，临床试验监测和/或治疗体重障碍（包括但不限于肥胖，恶病质和厌食）的obR基因表达或ObR活性的其它化合物。
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7.发明授权Ob receptor and methods for the diagnosis and treatment of body weight disorders 失效Ob受体和用于诊断和治疗体重紊乱的方法公开(公告)号：US06403552B1
公开(公告)日：2002-06-11
申请号：US09094410
申请日：1998-06-09
IPC分类号： A61K3817
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.
摘要翻译： 本发明涉及编码参与哺乳动物体重调节的受体蛋白Ob受体（ObR）的核苷酸的发现，鉴定和表征。 本发明包括obR核苷酸，宿主细胞表达系统，ObR蛋白，融合蛋白，多肽和肽，受体抗体，表达obR转基因的转基因动物或不表达ObR的拮抗剂和激动剂的重组敲除动物 的受体和调节可用于诊断，药物筛选，临床试验监测和/或治疗体重障碍（包括但不限于肥胖，恶病质和厌食）的obR基因表达或ObR活性的其它化合物。
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公开(公告)号：US06548269B1
公开(公告)日：2003-04-15
申请号：US08638524
申请日：1996-04-26
IPC分类号： C12P2102
CPC分类号： G06F9/52 , A61K38/00 , C07K14/715 , C07K2319/00
摘要： The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.
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9.发明授权公开(公告)号：US06509189B1
公开(公告)日：2003-01-21
申请号：US08570142
申请日：1995-12-11
IPC分类号： C12N506
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： The presention invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.
摘要翻译： 本发明涉及编码参与哺乳动物体重调节的受体蛋白Ob受体（ObR）的核苷酸的发现，鉴定和表征。 本发明包括obR核苷酸，宿主细胞表达系统，ObR蛋白，融合蛋白，多肽和肽，受体抗体，表达obR转基因的转基因动物或不表达ObR的拮抗剂和激动剂的重组敲除动物 的受体和调节可用于诊断，药物筛选，临床试验监测和/或治疗体重障碍（包括但不限于肥胖，恶病质和厌食）的obR基因表达或ObR活性的其它化合物。
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公开(公告)号：US06506877B1
公开(公告)日：2003-01-14
申请号：US08583153
申请日：1995-12-28
IPC分类号： C07K1471
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.
摘要翻译： 本发明涉及编码参与哺乳动物体重调节的受体蛋白Ob受体（ObR）的核苷酸的发现，鉴定和表征。 本发明包括obR核苷酸，宿主细胞表达系统，ObR蛋白，融合蛋白，多肽和肽，受体抗体，表达obR转基因的转基因动物或不表达ObR的拮抗剂和激动剂的重组敲除动物 的受体和调节可用于诊断，药物筛选，临床试验监测和/或治疗体重障碍（包括但不限于肥胖，恶病质和厌食）的obR基因表达或ObR活性的其它化合物。
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