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    Method for tinting hydrophilic plastic articles
    21.
    发明授权
    Method for tinting hydrophilic plastic articles 失效
    亲水性塑料制品着色方法

    公开(公告)号：US4898695A

    公开(公告)日：1990-02-06

    申请号：US265523

    申请日：1988-11-01

    Applicant: Praful Doshi

    Inventor： Praful Doshi

    IPC: G02C7/04 ,  B29D11/00 ,  G02B1/04 ,  G02C7/02 ,  G02C13/00

    CPC classification number: B29D11/00903 ,  G02B1/043

    Abstract: Tinted hydrophilic plastic articles, such as soft contact lenses, are prepared by carrying out the tinting operation while the hydrophilic material is still in its non-hydrated state. Tinting at this point avoids the need for use of swelling agents and also permits integration of the tinting procedure into an overall automated manufacturing operation. A preferred embodiment of the invention is an integrated process for producing a tinted soft contact lens comprising the steps of providing a casting mold having an arbor formed as a cup shaped container, filling said container with a monomeric lens forming liquid, polymerizing said liquid to produce a lens blank having one optical surface formed by the bottom of said cup shaped container, generating (e.g., machining) a second optical surface on said blank while said casting mold is mounted on a precision mandrel, tinting said resulting lens by impregnating the pores of said blank with a dispersion of a solubilized vat dye precursor and subsequently precipitatintg an insoluble vat dye within said pores, the blank being rinsed both before and after precipitation of said vat dye while still mounted in said casting mold, drying said blank to return it to a substantially xerogel state, edging and further processing said blank to convert it into a tinted hydrated soft contact lens, and subsequently hydrating said lens. While the foregoing is the preferred embodiment, the method may be utilized at the xerogel stage in all other presently known methods of forming lenses, e.g., lathing, cast molding and spin casting.

    Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia
    23.
    发明授权
    Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia 有权

    公开(公告)号：US10413506B2

    公开(公告)日：2019-09-17

    申请号：US16188833

    申请日：2018-11-13

    Applicant: Praful Doshi

    Inventor： Praful Doshi

    IPC: A61K9/00 ,  C08F220/28 ,  C08L33/08 ,  A61L27/54 ,  G02B1/04 ,  A61K31/5377 ,  C08F2/48 ,  A61L31/16 ,  C08L33/10 ,  A61L12/00

    Abstract: The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having a coating made at least in part using printing technologies to provide drug storage and drug release structures. The coating preferably includes at least one drug reservoir layer and a least one barrier layer, and can include structures, such as but not limited to capillary structures that alone or in combination modulate the release of the drug from the coating. One aspect of the present invention is a medical device that incorporates a drug in at least one coating. A second aspect of the present invention is a method of making a medical device that incorporates a drug in at least one coating. A third aspect of the present invention is a method of using a medical device of the present invention to treat, prevent from having, prevent from developing, control, reduce the severity, or reduce the progression of a disease, disorder or condition of a subject.

    Medical devices including medicaments and methods of making and using same
    25.
    发明授权
    Medical devices including medicaments and methods of making and using same 有权

    公开(公告)号：US10188604B2

    公开(公告)日：2019-01-29

    申请号：US16023156

    申请日：2018-06-29

    Applicant: Praful Doshi

    Inventor： Praful Doshi

    IPC: A61K9/51 ,  A61K9/00 ,  C08L33/10 ,  A61K31/5377 ,  A61L27/54 ,  C08L33/08 ,  C08F220/28 ,  C08F2/48 ,  G02B1/04 ,  A61L31/16 ,  A61L12/00

    Abstract: The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having a coating made at least in part using printing technologies to provide drug storage and drug release structures. The coating preferably includes at least one drug reservoir layer and a least one barrier layer, and can include structures, such as but not limited to capillary structures, which alone or in combination modulate the release of the drug from the coating. One aspect of the present invention is a medical device that incorporates a drug in at least one coating. A second aspect of the present invention is a method of making a medical device that incorporates a drug in at least one coating. A third aspect of the present invention is a method of using a medical device of the present invention to treat or prevent a disease, disorder or condition.

    Medical devices including medicaments and methods of making and using same
    28.
    发明申请
    Medical devices including medicaments and methods of making and using same 审中-公开
    医疗器械包括药物及其制造和使用方法

    公开(公告)号：US20110244010A1

    公开(公告)日：2011-10-06

    申请号：US13065904

    申请日：2011-04-02

    Applicant: Praful Doshi

    Inventor： Praful Doshi

    IPC: A61K9/00 ,  A61K9/70 ,  A61P27/02 ,  C08F2/46 ,  C08F220/28 ,  B05D1/02 ,  B05D1/18 ,  B05D1/30 ,  B05D1/36 ,  B05D5/00 ,  B05D1/00

    CPC classification number: A61K9/0051 ,  A61K31/5377 ,  A61L12/00 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/00 ,  C08F2/48 ,  C08F220/28 ,  C08L33/08 ,  C08L33/10 ,  G02B1/043

    Abstract: The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having a coating made at least in part using printing technologies to provide drug storage and drug release structures. The coating preferably includes at least one drug reservoir layer and a least one barrier layer, and can include structures, such as but not limited to capillary structures, that alone or in combination modulate the release of the drug from the coating. One aspect of the present invention is a medical device that incorporates a drug in at least one coating. A second aspect of the present invention is a method of making a medical device that incorporates a drug in at least one coating. A third aspect of the present invention is a method of using a medical device of the present invention to treat or prevent a disease, disorder or condition.

    Abstract translation: 本发明认识到，医疗装置，例如但不限于隐形眼镜，可以制成具有至少部分使用印刷技术制成的涂层来提供药物储存和药物释放结构。 涂层优选包括至少一个药物储存层和至少一个阻挡层，并且可以包括单独或组合地调节药物从涂层释放的结构，例如但不限于毛细管结构。 本发明的一个方面是将药物并入至少一个涂层中的医疗装置。 本发明的第二方面是制造在至少一个涂层中并入药物的医疗装置的方法。 本发明的第三方面是使用本发明的医疗装置来治疗或预防疾病，病症或病症的方法。

    Tinted lenses and methods of manufacture
    29.
    发明授权
    Tinted lenses and methods of manufacture 有权
    有色镜片和制造方法

    公开(公告)号：US07549742B2

    公开(公告)日：2009-06-23

    申请号：US11188242

    申请日：2005-07-22

    Applicant: Praful Doshi

    Inventor： Praful Doshi

    IPC: G02C7/02

    CPC classification number: G02C7/108 ,  B29D11/00903 ,  C09D11/101 ,  G02B1/043 ,  G02C7/04

    Abstract: The present invention recognizes that lenses, such as contact lenses, can be pigmented using ink that includes polymers or polymerizable monomers, preferably the same monomers used to make the lens. The ink can be used to make images on or within the lens. Images made using these inks are preferably digital and can be used in a variety of printing methods, including ink-jet printing.

    Abstract translation: 本发明认识到，可以使用包括聚合物或可聚合单体的油墨，优选用于制造透镜的相同单体，使透镜，例如隐形眼镜着色。 墨水可用于在镜头上或镜片内制作图像。 使用这些油墨制成的图像优选是数字式的，并且可以用于各种印刷方法，包括喷墨印刷。

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