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54 条记录 (耗时 0.038 秒)

    Methods and compositions for the treatment of neuropathies and related disorders
    21.
    发明申请
    Methods and compositions for the treatment of neuropathies and related disorders 审中-公开
    用于治疗神经病和相关疾病的方法和组合物

    公开(公告)号：US20070082939A1

    公开(公告)日：2007-04-12

    申请号：US11492608

    申请日：2006-07-24

    申请人： Arnold Lippa ,  Phil Skolnick ,  Anthony Basile ,  Zhengming Chen ,  Joseph Epstein

    发明人： Arnold Lippa ,  Phil Skolnick ,  Anthony Basile ,  Zhengming Chen ,  Joseph Epstein

    IPC分类号： A61K31/403

    CPC分类号： A61K31/403

    摘要： The present invention provides novel compositions and methods for treating symptoms associated with neuropathic disorders such as hyperalgesia, allodynia, and parasthesias, using a 1-aryl-3-azabicyclo[3.1.0] hexane. The invention further relates to the use of 1-aryl-3-azabicyclo[3.1.0] hexanes in pharmaceutical compositions and methods for treating neuropathic disorders and related symptoms in mammals. Patients amenable to treatment according to the invention include those suffering from diabetic neuropathies, post-herpetic neuralgia, trigeminal neuralgia, chronic lower back pain, sciatica, idiopathic and post-traumatic neuropathies, HIV-associated neuropathic pain, among many other neuropathic disorders and related symptoms.

    摘要翻译： 本发明提供了使用1-芳基-3-氮杂双环[3.1.0]己烷治疗与神经性疾病相关的症状的新颖的组合物和方法，所述神经性疾病例如痛觉过敏，异常性疼痛和副症状。 本发明还涉及1-芳基-3-氮杂双环[3.1.0]己烷在用于治疗哺乳动物神经病症和相关症状的药物组合物和方法中的用途。 根据本发明治疗的患者包括患有糖尿病性神经病，疱疹后神经痛，三叉神经痛，慢性下背痛，坐骨神经痛，特发性和创伤后神经病变，HIV相关神经性疼痛等许多其他神经病变和相关的患者 症状

    Methods and compositions for production, formulation and use of 1-aryl-3-azabicyclo[3.1.0]hexanes
    22.
    发明申请
    Methods and compositions for production, formulation and use of 1-aryl-3-azabicyclo[3.1.0]hexanes 审中-公开
    用于生产，配制和使用1-芳基-3-氮杂双环[3.1.0]己烷的方法和组合物

    公开(公告)号：US20060223875A1

    公开(公告)日：2006-10-05

    申请号：US11371178

    申请日：2006-03-07

    申请人： Phil Skolnick ,  Anthony Basile ,  Zhengming Chen

    发明人： Phil Skolnick ,  Anthony Basile ,  Zhengming Chen

    IPC分类号： A61K31/403 ,  C07D209/00

    CPC分类号： C07D209/52

    摘要： The invention provides novel 1-aryl-3-azabicyclo[3.1.0]hexanes that are active for modulating biogenic amine transport, along with compositions and methods for using these compounds to treat central nervous system disorders. Certain 1-aryl-3-azabicyclo[3.1.0]hexanes are provided that have at least one substituent on the aryl ring. In other embodiments 1-aryl-3-azabicyclo[3.1.0]hexanes are provided that have a substitution on the nitrogen at the ‘3’ position. In additional embodiments 1-aryl-3-azabicyclo[3.1.0]hexanes are provided which have one substitution on the aryl ring, as well as a substitution on the nitrogen at the ‘3’ position. The invention also provides novel methods of making aryl- and aza-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, including synthetic methods that form novel intermediate compounds of the invention for producing aryl- and aza-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes.

    摘要翻译： 本发明提供了用于调节生物胺转运的新型1-芳基-3-氮杂双环[3.1.0]己烷，以及使用这些化合物治疗中枢神经系统疾病的组合物和方法。 提供在芳基环上具有至少一个取代基的某些1-芳基-3-氮杂双环[3.1.0]己烷。 在其它实施方案中，提供1-氮杂双环[3.1.0]己烷，其在“3”位上在氮上具有取代基。 在另外的实施方案中，提供1-芳基-3-氮杂双环[3.1.0]己烷，其在芳基环上具有一个取代基，以及在“3”位置的氮上进行取代。 本发明还提供制备芳基和氮杂取代的1-芳基-3-氮杂双环[3.1.0]己烷的新方法，包括形成本发明的新型中间体化合物的合成方法，用于制备芳基和氮杂取代的1-芳基 -3-氮杂双环[3.1.0]己烷。

    Semiconductor substrate batch demounting apparatus
    23.
    发明授权
    Semiconductor substrate batch demounting apparatus 失效
    半导体衬底批量拆装器

    公开(公告)号：US06752160B2

    公开(公告)日：2004-06-22

    申请号：US10418324

    申请日：2003-04-17

    申请人： Zhengming Chen

    发明人： Zhengming Chen

    IPC分类号： B08B304

    CPC分类号： H01L21/67781 ,  Y10S134/902

    摘要： The embodiment of this invention is an apparatus that provides for a cassette-to-cassette batch demounting process wherein the apparatus has two cassettes for holding and separating semiconductor substrates. A first cassette is placed on top of a second cassette, using the first cassette as the top cassette that holds the semiconductor substrate and the support substrate, and the second cassette at the bottom as a bottom cassette that receives the semiconductor substrate after demounting process. The semiconductor substrate is loaded with its support substrate into a slot in the top cassette. The top cassette will let only the semiconductor substrate to descend to the bottom cassette while blocking the support substrate from exiting the top cassette. The two cassettes are then soaked in a hot solvent that can dissolve or melt an adhesive that adheres the semiconductor substrate to the support substrate in order to weaken the cohesive force between the two substrates. The thinned semiconductor substrate will gradually demount from its support substrate by gravitational force and vertically slides down into the bottom cassette.

    摘要翻译： 本发明的实施例是一种提供盒式到盒式批量拆卸方法的装置，其中该装置具有用于保持和分离半导体衬底的两个盒。 第一盒被放置在第二盒的顶部上，使用第一盒作为保持半导体衬底和支撑衬底的顶盒，底部的第二盒作为在拆卸之后接收半导体衬底的底盒。 半导体衬底将其支撑衬底装载到顶盒中的狭槽中。 顶部盒式磁带将仅使半导体衬底下降到底部盒，同时阻止支撑衬底离开顶部盒。 然后将两个盒浸泡在热溶剂中，该热溶剂可溶解或熔化将半导体衬底粘附到支撑衬底上的粘合剂，以便削弱两个衬底之间的内聚力。 减薄的半导体衬底将通过重力从其支撑衬底逐渐脱落并且垂直地向下滑入底部盒。

    Tropane analogs and methods for inhibition of monoamine transport
    24.
    发明授权
    Tropane analogs and methods for inhibition of monoamine transport 有权
    托烷类似物和抑制单胺转运的方法

    公开(公告)号：US06417221B1

    公开(公告)日：2002-07-09

    申请号：US09671534

    申请日：2000-09-27

    申请人： Peter C. Meltzer ,  Bertha K. Madras ,  Paul Blundell ,  Zhengming Chen

    发明人： Peter C. Meltzer ,  Bertha K. Madras ,  Paul Blundell ,  Zhengming Chen

    IPC分类号： A61K3138

    CPC分类号： C07D451/02 ,  A61K31/18 ,  A61K31/198 ,  A61K31/405 ,  A61K38/00 ,  A61K51/0448 ,  A61K2123/00 ,  C07C69/753 ,  C07C2602/44 ,  C07D451/06 ,  C07D471/08 ,  C07D493/08

    摘要： New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7- substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain preferred compounds of the present invention have a high selectivity for the DAT versus the SERT. Also described are pharmaceutical therapeutic compositions comprising the compounds formulated in a pharmaceutically acceptable carrier and a method for inhibiting 5-hydroxy-tryptamine reuptake of a monoamine transporter by contacting the monoamine transporter with a 5-hydroxytryptamine reuptake inhibiting amount of a compound of the present invention. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.

    摘要翻译： 描述了结合单胺转运蛋白的新的托烷类似物，特别是具有6-或7-取代基的8-氮杂，8-碳代和8-氧代正丙烷。 本发明的化合物可以是外消旋的，纯的R-对映体或纯的S-对映异构体。 某些优选的本发明化合物对于DAT与SERT具有高选择性。 还描述了包含配制在药学上可接受的载体中的化合物的药物治疗组合物和通过使单胺转运蛋白与5-羟色胺重摄取抑制量的本发明化合物接触来抑制单胺转运蛋白的5-羟基 - 色胺再摄取的方法 。 用于实施本发明的优选的单胺转运蛋白包括多巴胺转运蛋白，5-羟色胺转运蛋白和去甲肾上腺素转运蛋白。

    Therapeutic agents useful for treating pain
    30.
    发明申请
    Therapeutic agents useful for treating pain 有权

    公开(公告)号：US20070179141A1

    公开(公告)日：2007-08-02

    申请号：US11729660

    申请日：2007-03-28

    申请人： Zhengming Chen

    发明人： Zhengming Chen

    IPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  C07D413/14 ,  C07D403/14

    CPC分类号： C07D401/04 ,  C07D211/64 ,  C07D401/14

    摘要： 4-Tetrazolyl-4-phenylpiperidine Compounds, compositions comprising an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound, methods for treating or preventing pain or diarrhea in an animal comprising administering to an animal in need thereof an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound and methods for stimulating opioid-receptor function in a cell comprising contacting a cell capable of expressing an opioid receptor with an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound are disclosed.