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21.发明申请Vanilloid receptor ligand compounds, pharmaceutical compositions containing them, a method of producing them and the use thereof to treat pain and various other conditions 失效香草酸受体配体化合物，含有它们的药物组合物，其制备方法及其用于治疗疼痛和各种其它病症的用途公开(公告)号：US20080269289A1
公开(公告)日：2008-10-30
申请号：US12081174
申请日：2008-04-11
申请人： Robert Frank , Gregor Bahrenberg , Thomas Christoph , Klaus Schiene , Jean De Vry , Derek Saunders , Jeewoo Lee
发明人： Robert Frank , Gregor Bahrenberg , Thomas Christoph , Klaus Schiene , Jean De Vry , Derek Saunders , Jeewoo Lee
IPC分类号： A61K31/4545 , C07D211/06 , A61P17/02 , A61P9/12 , A61P31/12
CPC分类号： C07D211/08 , C07C311/08 , C07C323/41 , C07C2601/14 , C07D211/14 , C07D213/70 , C07D401/04
摘要： Compounds corresponding to formula I: which act as vanilloid receptor ligands, pharmaceutical composition s containing such compounds, a method for producing the compounds, and the use of such compounds to treat pain and various other conditions.
摘要翻译： 对应于式I的化合物：其作为香草素受体配体，含有这些化合物的药物组合物，制备化合物的方法，以及这些化合物用于治疗疼痛和各种其它病症的用途。
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22.发明授权Substituted tetrahydropyrrolopyrazine compounds and the use thereof in pharmaceutical compositions 失效取代的四氢吡咯并吡嗪化合物及其在药物组合物中的用途公开(公告)号：US07879858B2
公开(公告)日：2011-02-01
申请号：US12425873
申请日：2009-04-17
申请人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
发明人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
IPC分类号： A61K31/495
CPC分类号： C07D487/04
摘要： Substituted tetrahydropyrrolopyrazine compounds corresponding to formula I a process for producing such compounds; and a method of using such compounds to treat or inhibit various disorders or disease states including pain, depression and anxiety.
摘要翻译： 对应于式I的取代的四氢吡咯并吡嗪化合物是制备这些化合物的方法; 以及使用这些化合物治疗或抑制各种疾病或疾病状态（包括疼痛，抑郁和焦虑）的方法。
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23.发明申请Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in Pharmaceutical Compositions 失效取代的四氢吡咯并吡嗪化合物及其在药物组合物中的应用公开(公告)号：US20090258880A1
公开(公告)日：2009-10-15
申请号：US12425873
申请日：2009-04-17
申请人： Beatrix MERLA , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
发明人： Beatrix MERLA , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
IPC分类号： A61K31/4985 , C07D489/04 , A61P25/00
CPC分类号： C07D487/04
摘要： Substituted tetrahydropyrrolopyrazine compounds corresponding to formula I a process for producing such compounds; and a method of using such compounds to treat or inhibit various disorders or disease states including pain, depression and anxiety.
摘要翻译： 对应于式I的取代的四氢吡咯并吡嗪化合物是制备这些化合物的方法; 以及使用这些化合物治疗或抑制各种疾病或疾病状态（包括疼痛，抑郁和焦虑）的方法。
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24.发明授权Substituted tetrahydropyrrolopyrazine compounds and the use thereof in the treatment and/or inhibition of pain 失效取代的四氢吡咯并吡嗪化合物及其在治疗和/或抑制疼痛中的用途公开(公告)号：US08017772B2
公开(公告)日：2011-09-13
申请号：US12558008
申请日：2009-09-11
申请人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
发明人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
IPC分类号： C07D471/00
CPC分类号： C07D487/04
摘要： Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K+ channels.
摘要翻译： 对应于式I的取代的四氢吡咯并吡嗪化合物：其制备方法，包含这些化合物的药物组合物以及这些化合物用于治疗和/或抑制至少部分由KCNQ2 / 3K +通道介导的疼痛和其它疾病或疾病状态的用途 。
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25.发明申请Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in the Treatment and/or Inhibition of Pain 失效取代的四氢吡咯并吡嗪化合物及其用途在疼痛的治疗和/或抑制中公开(公告)号：US20080167315A1
公开(公告)日：2008-07-10
申请号：US11873574
申请日：2007-10-17
申请人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
发明人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
IPC分类号： A61K31/4985 , C07D487/04 , A61P29/00
CPC分类号： C07D487/04
摘要： Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K+ channels.
摘要翻译： 对应于式I的取代的四氢吡咯并吡嗪化合物：其制备方法，包含这些化合物的药物组合物以及这些化合物用于治疗和/或抑制至少部分由KCNQ2 / 3K介导的疼痛和其他疾病或疾病状态的用途， SUP> + 频道。
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26.发明授权Sutstituted tetrahydropyrrolopyrazine compounds and the use thereof in the treatment and/or inhibition of pain 失效取代的四氢吡咯并吡嗪化合物及其在治疗和/或抑制疼痛中的用途公开(公告)号：US07625900B2
公开(公告)日：2009-12-01
申请号：US11873574
申请日：2007-10-17
申请人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
发明人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
IPC分类号： A61K31/495
CPC分类号： C07D487/04
摘要： Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K+ channels.
摘要翻译： 对应于式I的取代的四氢吡咯并吡嗪化合物：其制备方法，包含这些化合物的药物组合物以及这些化合物用于治疗和/或抑制至少部分由KCNQ2 / 3K +通道介导的疼痛和其它疾病或疾病状态的用途 。
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公开(公告)号：US08084470B2
公开(公告)日：2011-12-27
申请号：US12212369
申请日：2008-09-17
申请人： Beatrix Merla , Sven Kuehnert , Robert Frank , Dagmar Kaulartz , Wolfgang Schroeder , Gregor Bahrenberg , Klaus Schiene
发明人： Beatrix Merla , Sven Kuehnert , Robert Frank , Dagmar Kaulartz , Wolfgang Schroeder , Gregor Bahrenberg , Klaus Schiene
IPC分类号： C07D409/14 , A61K31/444
CPC分类号： C07D213/82 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Substituted nicotinamide compounds corresponding to formula I a process for their preparation, pharmaceutical compositions containing these compounds, and the use thereof for the treatment or inhibition conditions such as pain, epilepsy, migraine, anxiety states, or urinary incontinence.
摘要翻译： 对应于式I的取代烟酰胺化合物，其制备方法，含有这些化合物的药物组合物及其用于治疗或抑制病症如疼痛，癫痫，偏头痛，焦虑状态或尿失禁的用途。
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公开(公告)号：US20090076086A1
公开(公告)日：2009-03-19
申请号：US12212369
申请日：2008-09-17
申请人： Beatrix Merla , Sven Kuehnert , Robert Frank , Dagmar Kaulartz , Wolfgang Schroeder , Gregor Bahrenberg , Klaus Schiene
发明人： Beatrix Merla , Sven Kuehnert , Robert Frank , Dagmar Kaulartz , Wolfgang Schroeder , Gregor Bahrenberg , Klaus Schiene
IPC分类号： A61K31/444 , C07D409/14
CPC分类号： C07D213/82 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Substituted nicotinamide compounds corresponding to formula I a process for their preparation, pharmaceutical compositions containing these compounds, and the use thereof for the treatment or inhibition conditions such as pain, epilepsy, migraine, anxiety states, or urinary incontinence.
摘要翻译： 对应于式I的取代烟酰胺化合物，其制备方法，含有这些化合物的药物组合物及其用于治疗或抑制病症如疼痛，癫痫，偏头痛，焦虑症或尿失禁的用途。
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29.发明授权Substituted 4-(1.2,3,4-tetrahydroisoquinolin-2-yl)-4-oxobutyric acid amide as KCNQ2/3 modulators 失效取代4-（1.2,3,4-四氢异喹啉-2-基）-4-氧代丁酸酰胺，为KCNQ2 / 3调节剂公开(公告)号：US08367700B2
公开(公告)日：2013-02-05
申请号：US12635800
申请日：2009-12-11
IPC分类号： A61K31/4709 , A61P25/00 , C07D217/12
CPC分类号： C07D217/06 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D417/12
摘要： The invention relates to substituted tetrahydroisoquinolinyl-4-oxobutyric acid amides, methods for the preparation thereof, medicinal products containing these compounds and the use of these compounds for the preparation of medicinal products.
摘要翻译： 本发明涉及取代的四氢异喹啉基-4-氧代丁酰胺，其制备方法，含有这些化合物的医药产品以及这些化合物用于制备药用产品的用途。
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公开(公告)号：US07879991B2
公开(公告)日：2011-02-01
申请号：US10513490
申请日：2003-05-06
申请人： Axel Vater , Christian Maasch , Florian Jarosch , Mathias Bell , Steffen Helmling , Bernd Eschgfäller , Elisabeth Moyroud , Sandra Stark , Sven Klussmann , Thorsten Ruppert , Gregor Bahrenberg , Clemens Gillen , Klaus Schiene
发明人： Axel Vater , Christian Maasch , Florian Jarosch , Mathias Bell , Steffen Helmling , Bernd Eschgfäller , Elisabeth Moyroud , Sandra Stark , Sven Klussmann , Thorsten Ruppert , Gregor Bahrenberg , Clemens Gillen , Klaus Schiene
IPC分类号： C07H21/04
CPC分类号： C12N15/115
摘要： The invention relates to an antagonist for CGRP and amylin, whereby the antagonist is a nucleic acid and said nucleic acid binds to CGRP or amylin. Said nucleic acid preferably comprises an L-nucleotide.
摘要翻译： 本发明涉及用于CGRP和胰岛淀粉样多肽的拮抗剂，其中所述拮抗剂是核酸，并且所述核酸与CGRP或胰岛淀粉样多肽结合。 所述核酸优选包含L-核苷酸。
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