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    Ghrelin binding nucleic acids
    3.
    发明授权
    Ghrelin binding nucleic acids 失效
    生长素释放肽结合核酸

    公开(公告)号：US08101734B2

    公开(公告)日：2012-01-24

    申请号：US11400459

    申请日：2006-04-07

    申请人： Florian Jarosch ,  Dirk Eulberg ,  Christian Maasch ,  Steffen Helmling ,  Sven Klussmann

    发明人： Florian Jarosch ,  Dirk Eulberg ,  Christian Maasch ,  Steffen Helmling ,  Sven Klussmann

    IPC分类号： C07H21/04

    CPC分类号： C12N15/115 ,  C12N2310/16 ,  C12N2310/3183 ,  C12N2310/351 ,  C12N2310/53

    摘要： The present invention is related to a nucleic acid, preferably binding to ghrelin, whereby the nucleic acid comprises a first stretch Box A, and a second stretch Box B, whereby the first stretch Box A comprises about 25 consecutive nucleotides, the second stretch Box B comprises about six to eight consecutive nucleotides, whereby a 3′-terminal stretch of nucleotides of the first stretch Box A hybridizes with the second stretch Box B, whereby upon hybridization a first double-stranded structure is formed, whereby such first double-stranded structure comprises a bulge.

    摘要翻译： 本发明涉及核酸，优选结合生长素释放肽，其中核酸包含第一拉伸盒A和第二拉伸盒B，其中第一拉伸盒A包含约25个连续核苷酸，第二拉伸盒B 包含约六至八个连续核苷酸，其中第一拉伸盒A的核苷酸的3'末端部分与第二拉伸盒B杂交，由此在杂交时形成第一双链结构，由此形成第一双链结构 包括凸起。

    Ghrelin binding nucleic acids
    4.
    发明申请
    Ghrelin binding nucleic acids 审中-公开
    生长素释放肽结合核酸

    公开(公告)号：US20120115937A1

    公开(公告)日：2012-05-10

    申请号：US13356816

    申请日：2012-01-24

    申请人： Florian Jarosch ,  Dirk Eulberg ,  Christian Maasch ,  Steffen Helmling ,  Sven Klussmann

    发明人： Florian Jarosch ,  Dirk Eulberg ,  Christian Maasch ,  Steffen Helmling ,  Sven Klussmann

    IPC分类号： A61K31/7088 ,  C07K14/575 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C12N15/115 ,  C12N2310/16 ,  C12N2310/3183 ,  C12N2310/351 ,  C12N2310/53

    摘要： The present invention is related to a nucleic acid, preferably binding to ghrelin, whereby the nucleic acid comprises a first stretch Box A, and a second stretch Box B, whereby the first stretch Box A comprises about 25 consecutive nucleotides, the second stretch Box B comprises about six to eight consecutive nucleotides, whereby a 3′-terminal stretch of nucleotides of the first stretch Box A hybridises with the second stretch Box B, whereby upon hybridisation a first double-stranded structure is formed, whereby such first double-stranded structure comprises a bulge.

    摘要翻译： 本发明涉及核酸，优选结合生长素释放肽，其中核酸包含第一拉伸盒A和第二拉伸盒B，其中第一拉伸盒A包含约25个连续核苷酸，第二拉伸盒B 包含约六至八个连续核苷酸，其中第一拉伸盒A的核苷酸的3'末端拉伸与第二拉伸盒B杂交，由此在杂交时形成第一双链结构，由此形成第一双链结构 包括凸起。

    Ghrelin binding nucleic acids
    5.
    发明申请
    Ghrelin binding nucleic acids 失效
    生长素释放肽结合核酸

    公开(公告)号：US20060258607A1

    公开(公告)日：2006-11-16

    申请号：US11400459

    申请日：2006-04-07

    申请人： Florian Jarosch ,  Dirk Eulberg ,  Christian Maasch ,  Steffen Helmling ,  Sven Klussmann

    发明人： Florian Jarosch ,  Dirk Eulberg ,  Christian Maasch ,  Steffen Helmling ,  Sven Klussmann

    IPC分类号： A61K48/00 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C12N15/115 ,  C12N2310/16 ,  C12N2310/3183 ,  C12N2310/351 ,  C12N2310/53

    摘要： The present invention is related to a nucleic acid, preferably binding to ghrelin, whereby the nucleic acid comprises a first stretch Box A, and a second stretch Box B, whereby the first stretch Box A comprises about 25 consecutive nucleotides, the second stretch Box B comprises about six to eight consecutive nucleotides, whereby a 3′-terminal stretch of nucleotides of the first stretch Box A hybridises with the second stretch Box B, whereby upon hybridisation a first double-stranded structure is formed, whereby such first double-stranded structure comprises a bulge.

    摘要翻译： 本发明涉及核酸，优选结合生长素释放肽，其中核酸包含第一拉伸盒A和第二拉伸盒B，其中第一拉伸盒A包含约25个连续核苷酸，第二拉伸盒B 包含约六至八个连续核苷酸，其中第一拉伸盒A的核苷酸的3'末端拉伸与第二拉伸盒B杂交，由此在杂交时形成第一双链结构，由此形成第一双链结构 包括凸起。

    Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
    6.
    发明授权
    Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same 有权

    公开(公告)号：US09976145B2

    公开(公告)日：2018-05-22

    申请号：US13978804

    申请日：2012-01-10

    申请人： Florian Jarosch ,  Sven Klussmann ,  Simone Sell ,  Werner Purschke ,  Christian Maasch ,  Axel Vater ,  Kai Hohlig

    发明人： Florian Jarosch ,  Sven Klussmann ,  Simone Sell ,  Werner Purschke ,  Christian Maasch ,  Axel Vater ,  Kai Hohlig

    IPC分类号： C12N15/115 ,  C12N15/11 ,  G01N33/53 ,  C12N15/10

    CPC分类号： C12N15/115 ,  C12N15/102 ,  C12N15/111 ,  C12N2310/16 ,  C12N2310/32 ,  C12N2320/13 ,  C12N2330/31 ,  G01N33/5308 ,  G01N2400/10 ,  G01N2500/04

    摘要： The present invention is related to a method for generating a nucleic acid molecule capable of binding to a target molecule comprising the following steps: a) providing a reference nucleic acid molecule, wherein the reference nucleic acid molecule is capable of binding to the target molecule and wherein the reference nucleic acid molecule comprises a sequence of nucleotides, wherein the sequence of nucleotides comprises n nucleotides; b) preparing a first level derivative of the reference nucleic acid molecule, wherein the first level derivative of the reference nucleic acid molecule differs from the reference nucleic acid molecule at one nucleotide position, wherein the first level derivative is prepared by replacing the ribonucleotide at the one nucleotide position by a 2′-deoxyribonucleotide in case the reference nucleic acid has a ribonucleotide at the nucleotide position and wherein the first level derivative is prepared by replacing the 2′-deoxyribonucleotide at the one nucleotide position by a ribonucleotide in case the reference nucleic acid has a 2′-deoxyribonucleotide at the nucleotide position and wherein the nucleotide position at which the replacement is made is the modified nucleotide position; and c) repeating step b) for each nucleotide position of the reference nucleic acid molecule, thus preparing a group of first level derivatives of the reference nucleic acid molecule, wherein the group of first level derivatives of the reference nucleic acid molecule consists of n first level derivatives, wherein each of the first level derivatives of the reference nucleic acid molecule differs from the reference nucleic acid molecule by a single nucleotide replacement and wherein each of the first level derivatives of the reference nucleic acid molecule has a single modified nucleotide position which is different from the single modified nucleotide of all of the single modified nucleotide positions of the other first level derivatives of the group of first level derivatives of the reference nucleic acid molecule.

    Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
    7.
    发明申请
    Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same 有权

    公开(公告)号：US20140350088A1

    公开(公告)日：2014-11-27

    申请号：US13978804

    申请日：2012-01-10

    申请人： Florian Jarosch ,  Sven Klussmann ,  Simone Sell ,  Werner Purschke ,  Christian Maasch ,  Axel Vater ,  Kai Hohlig

    发明人： Florian Jarosch ,  Sven Klussmann ,  Simone Sell ,  Werner Purschke ,  Christian Maasch ,  Axel Vater ,  Kai Hohlig

    IPC分类号： C12N15/115 ,  G01N33/53 ,  C12N15/10

    CPC分类号： C12N15/115 ,  C12N15/102 ,  C12N15/111 ,  C12N2310/16 ,  C12N2310/32 ,  C12N2320/13 ,  C12N2330/31 ,  G01N33/5308 ,  G01N2400/10 ,  G01N2500/04

    摘要： The present invention is related to a method for generating a nucleic acid molecule capable of binding to a target molecule comprising the following steps: a) providing a reference nucleic acid molecule, wherein the reference nucleic acid molecule is capable of binding to the target molecule and wherein the reference nucleic acid molecule comprises a sequence of nucleotides, wherein the sequence of nucleotides comprises n nucleotides; b) preparing a first level derivative of the reference nucleic acid molecule, wherein the first level derivative of the reference nucleic acid molecule differs from the reference nucleic acid molecule at one nucleotide position, wherein the first level derivative is prepared by replacing the ribonucleotide at the one nucleotide position by a 2′-deoxyribonucleotide in case the reference nucleic acid has a ribonucleotide at the nucleotide position and wherein the first level derivative is prepared by replacing the 2′-deoxyribonucleotide at the one nucleotide position by a ribonucleotide in case the reference nucleic acid has a 2′-deoxyribonucleotide at the nucleotide position and wherein the nucleotide position at which the replacement is made is the modified nucleotide position; and c) repeating step b) for each nucleotide position of the reference nucleic acid molecule, thus preparing a group of first level derivatives of the reference nucleic acid molecule, wherein the group of first level derivatives of the reference nucleic acid molecule consists of n first level derivatives, wherein each of the first level derivatives of the reference nucleic acid molecule differs from the reference nucleic acid molecule by a single nucleotide replacement and wherein each of the first level derivatives of the reference nucleic acid molecule has a single modified nucleotide position which is different from the single modified nucleotide of all of the single modified nucleotide positions of the other first level derivatives of the group of first level derivatives of the reference nucleic acid molecule.