Alkylamine derivatives of dihydropyridine NPY antagonists
    25.
    发明授权
    Alkylamine derivatives of dihydropyridine NPY antagonists 有权
    二氢吡啶NPY拮抗剂的烷基胺衍生物

    公开(公告)号:US06479482B2

    公开(公告)日:2002-11-12

    申请号:US09852983

    申请日:2001-05-10

    IPC分类号: C07D41714

    CPC分类号: C07D401/12 C07D211/90

    摘要: A series of non-peptidergic antagonists of NPY have been synthesized and are comprises of amino and piperazine derivatives of 4-phenyl-1,4-dihydropyridines of Formula 1. where X is CH or N As antagonists of NPY-induced behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

    摘要翻译: 已经合成了一系列NPY的非肽能拮抗剂,其由式1的4-苯基-1,4-二氢吡啶的氨基和哌嗪衍生物组成。其中X是NPY诱导行为的CH或NAs拮抗剂,这些化合物是 预期在促进减肥和治疗进食障碍中起到有效的厌氧剂的作用。