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    Method of controlling body temperature while reducing shivering
    22.
    发明授权
    Method of controlling body temperature while reducing shivering 有权
    减少发抖的方法来控制体温

    公开(公告)号：US06582457B2

    公开(公告)日：2003-06-24

    申请号：US09784930

    申请日：2001-02-15

    申请人： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    发明人： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    IPC分类号： A61F712

    CPC分类号： A61F7/123 ,  A61F2007/0095 ,  A61F2007/126 ,  A61K31/00 ,  A61K31/137 ,  A61K31/4174

    摘要： A method and apparatus for lowering the body temperature of a patient while reducing shivering by using a heat exchange device in combination with an &agr;2-adrenoreceptor agonist, a non-opiod analgesic monoamine uptake inhibitor or neuropeptide that temporarily reduces shivering. The devices disclosed include a catheter having a heat exchange balloon thereon with heat exchange fluid circulating through the interior of the balloon. The heat exchange balloon is placed in the vasculature of a patient, and heat exchange fluid at a temperature other than the temperature of the blood in the vasculature is circulated through the interior of the balloon to add or remove heat from the blood of the patient. Various &agr;2-adrenoreceptor agonist&agr;2-adrenoreceptor agonists, non-opiod analgesic monoamine uptake inhibitors and neuropeptides are disclosed including dexmedetomidine, nepofam and neurotensin and pharmaceutically acceptable salts thereof. A control system for the control of the patient's temperature is disclosed for controlling the patient'stemperature in conjunction with administering the &agr;2-adrenoreceptor agonist, non-opiod analgesic monoamine uptake inhibitor or neuropeptide.

    摘要翻译： 一种用于降低患者体温的方法和装置，同时通过使用热交换装置与α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂或神经肽暂时减轻发抖相结合来减轻发抖。 所公开的装置包括具有热交换球囊的导管，其中热交换流体循环通过气囊的内部。 将热交换球放置在患者的脉管系统中，并且在脉管系统中除血液温度以外的温度下的热交换流体循环通过气囊的内部以从患者的血液中添加或除去热量。 公开了各种α2-肾上腺素受体激动剂α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂和神经肽，其包括右美托咪定，尼美芬和神经降压素及其药学上可接受的盐。 公开了一种用于控制患者温度的控制系统，用于与施用α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂或神经肽一起控制患者的温度。

    METHOD FOR REDUCING MYOCARDIAL INFARCT BY APPLICATION OF INTRAVASCULAR HYPOTHERMIA
    24.
    发明申请
    METHOD FOR REDUCING MYOCARDIAL INFARCT BY APPLICATION OF INTRAVASCULAR HYPOTHERMIA 有权
    通过应用血管内皮抑素来减少心肌梗死的方法

    公开(公告)号：US20090254161A1

    公开(公告)日：2009-10-08

    申请号：US12415984

    申请日：2009-03-31

    申请人： Michael W. Dae ,  Wade A. Keller ,  Timothy R. Machold

    发明人： Michael W. Dae ,  Wade A. Keller ,  Timothy R. Machold

    IPC分类号： A61F7/12

    CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0076 ,  A61F2007/126 ,  A61M25/1002

    摘要： Methods and apparatus for preventing myocardial infarction, or lessening the size/severity of an evolving myocardial infarction, by cooling at least the affected area of the myocardium using an intravascular heat exchange catheter. The heat exchange catheter may be inserted into the vasculature (e.g., a vein) and advanced to a position wherein a heat exchanger on the catheter is located in or near the heart (e.g., within the vena cava near the patient's heart). Thereafter, the heat exchange catheter is used to cool the myocardium (or the entire body of the patient) to a temperature that effectively lessens the metabolic rate and/or oxygen consumption of the ischemic myocardial cells or otherwise protects the ischemic myocardium from undergoing irreversible damage or infarction.

    摘要翻译： 通过使用血管内热交换导管至少冷却至少心肌的受影响区域来预防心肌梗死或减轻心肌梗死的大小/严重程度的方法和装置。 热交换导管可以插入脉管系统（例如静脉）中并且前进到导管上的热交换器位于心脏中或附近（例如在患者心脏附近的腔静脉内）的位置。 此后，热交换导管用于将心肌（或患者的整个身体）冷却到有效降低缺血心肌细胞的代谢率和/或氧消耗的温度，或以其它方式保护缺血心肌免受不可逆损伤 或梗死。

    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia
    26.
    发明授权
    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia 有权
    通过低温抑制血小板活化，聚集和/或粘附

    公开(公告)号：US06544282B1

    公开(公告)日：2003-04-08

    申请号：US09790249

    申请日：2001-02-21

    申请人： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    发明人： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    IPC分类号： A61F700

    CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/126

    摘要： A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36° C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 C.). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.

    摘要翻译： 一种通过将热交换装置放置在患者的脉管系统中并使用该热交换装置来冷却患者来治疗人或动物患者的急性冠状动脉综合征（即不稳定型心绞痛或非Q波MI）或短暂性脑缺血发作的方法 达到血小板抑制（即，抑制血小板活化和/或聚集和/或粘附）的温度（例如30-36℃）。 可以向体温低于该患者发抖阈值（通常约35.5℃）的患者施用抗发抖药物或麻醉。 如果确定不再需要血小板抑制，例如当患者即将进行其中出血可能有问题的手术或介入手术时，通过使用血管内热交换装置可以快速逆转低体温诱导的血小板抑制 将患者的身体重温为正常体温或接近正常体温。

    INHIBITION OF PLATELET ACTIVATION, AGGREGATION AND/OR ADHESION BY HYPOTHERMIA
    27.
    发明申请
    INHIBITION OF PLATELET ACTIVATION, AGGREGATION AND/OR ADHESION BY HYPOTHERMIA 有权
    抑制血小板活化，聚集和/或粘附

    公开(公告)号：US20110166634A1

    公开(公告)日：2011-07-07

    申请号：US12962487

    申请日：2010-12-07

    申请人： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    发明人： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    IPC分类号： A61F7/12

    CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/126

    摘要： A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient=s vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36_C) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient=s shivering threshold (typically approximately 35.5 C). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient=s body to normothermia or near normothermia.

    摘要翻译： 一种通过在患者脉管系统中放置热交换装置并使用该热交换装置冷却来治疗人或动物患者的急性冠状动脉综合征（即不稳定心绞痛或非Q波MI）或短暂性脑缺血发作的方法 患者达到血小板抑制（即，抑制血小板活化和/或凝集和/或粘附）的温度（例如30-36℃）。 可以将抗发炎药物或麻醉剂施用于体温低于该患者发抖阈值（通常约35.5℃）的患者。 如果确定不再需要血小板抑制，例如当患者即将进行其中出血可能有问题的手术或介入手术时，通过使用血管内热交换装置可以快速逆转低体温诱导的血小板抑制 将患者身体重新加热至正常体温或接近正常体温。

    Method of controlling body temperature while reducing shivering
    28.
    发明授权
    Method of controlling body temperature while reducing shivering 有权
    减少发抖的方法来控制体温

    公开(公告)号：US07008444B2

    公开(公告)日：2006-03-07

    申请号：US10676880

    申请日：2003-10-01

    申请人： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    发明人： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    IPC分类号： A61F7/00

    CPC分类号： A61M25/00 ,  A61B2017/00084 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0295 ,  A61F2007/126 ,  A61M2205/36

    摘要： A method and apparatus for lowering the body temperature of a patient while reducing shivering by using a heat exchange device in combination with an α2-adrenoreceptor agonist, a non-opiod analgesic monoamine uptake inhibitor or neuropeptide that temporarily reduces shivering. The devices disclosed include a catheter having a heat exchange balloon thereon with heat exchange fluid circulating through the interior of the balloon. The heat exchange balloon is placed in the vasculature of a patient, and heat exchange fluid at a temperature other than the temperature of the blood in the vasculature is circulated through the interior of the balloon to add or remove heat from the blood of the patient. Various α2-adrenoreceptor agonistα2-adrenoreceptor agonists, non-opiod analgesic monoamine uptake inhibitors and neuropeptides are disclosed including dexmedetomidine, nefopam, neurotensin and anticonvulsant medications and pharmaceutically acceptable salts thereof. A control system for the control of the patient's temperature is disclosed for controlling the patient's temperature in conjunction with administering the α2-adrenoreceptor agonist, non-opiod analgesic monoamine uptake inhibitor or neuropeptide.

    摘要翻译： 一种用于降低患者体温的方法和装置，同时通过使用热交换装置与α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂或神经肽暂时减轻发抖相结合来减轻发抖。 所公开的装置包括具有热交换球囊的导管，其中热交换流体循环通过气囊的内部。 将热交换球放置在患者的脉管系统中，并且在脉管系统中除血液温度以外的温度下的热交换流体循环通过气囊的内部以从患者的血液中添加或除去热量。 公开了各种α2-肾上腺素受体激动剂α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂和神经肽，包括右美托咪定，奈福泮，神经降压素和抗惊厥药物及其药学上可接受的盐。 公开了用于控制患者体温的控制系统，用于与施用α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂或神经肽一起控制患者的温度。

    Method for reducing myocardial infarct by application of intravascular hypothermia
    29.
    发明授权
    Method for reducing myocardial infarct by application of intravascular hypothermia 有权
    通过应用血管内低温降低心肌梗塞的方法

    公开(公告)号：US06811551B2

    公开(公告)日：2004-11-02

    申请号：US09735314

    申请日：2000-12-12

    申请人： Michael W. Dae ,  Wade A. Keller ,  Timothy R. Machold

    发明人： Michael W. Dae ,  Wade A. Keller ,  Timothy R. Machold

    IPC分类号： A61B1804

    CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0076 ,  A61F2007/126 ,  A61M25/1002

    摘要： Methods and apparatus for preventing myocardial infarction, or lessening the size/severity of an evolving myocardial infarction, by cooling at least the affected area of the myocardium using an intravascular heat exchange catheter. The heat exchange catheter may be inserted into the vasculature (e.g., a vein) and advanced to a position wherein a heat exchanger on the catheter is located in or near the heart (e.g., within the vena cava near the patient's heart). Thereafter, the heat exchange catheter is used to cool the myocardium (or the entire body of the patient) to a temperature that effectively lessens the metabolic rate and/or oxygen consumption of the ischemic myocardial cells or otherwise protects the ischemic myocardium from undergoing irreversible damage or infarction.

    摘要翻译： 通过使用血管内热交换导管至少冷却至少心肌的受影响区域来预防心肌梗死或减轻心肌梗死的大小/严重程度的方法和装置。 热交换导管可以插入脉管系统（例如静脉）中并且前进到导管上的热交换器位于心脏中或附近（例如在患者心脏附近的腔静脉内）的位置。 此后，热交换导管用于将心肌（或患者的整个身体）冷却到有效降低缺血心肌细胞的代谢率和/或氧消耗的温度，或以其它方式保护缺血心肌免受不可逆损伤 或梗死。