公开(公告)号：US20050158340A1

公开(公告)日：2005-07-21

申请号：US11079002

申请日：2005-03-11

Applicant: Hong Jin ,  Roderick Tang ,  Shengqiang Li ,  Martin Bryant ,  David Clarke ,  Peter Palese

Inventor： Hong Jin ,  Roderick Tang ,  Shengqiang Li ,  Martin Bryant ,  David Clarke ,  Peter Palese

IPC: A61K39/00 ,  C07K14/11 ,  C07K14/135 ,  C12N7/04 ,  C12N15/86 ,  C12Q1/70 ,  C07H21/02 ,  C12N7/00 ,  C12Q1/68

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K2039/51 ,  A61K2039/5254 ,  A61K2039/5256 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/16022 ,  C12N2760/18522 ,  C12N2760/18543 ,  C12N2760/18561 ,  C12N2840/20

Abstract: The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present invention, the recombinant RS viral vectors and viruses are engineered to contain heterologous genes, including genes of other viruses, pathogens, cellular genes, tumor antigens, or to encode combinations of genes from different strains of RSV.

Abstract translation: 本发明涉及遗传工程重组RS病毒和含有用作疫苗的异源基因的病毒载体。 根据本发明，重组RS病毒载体和病毒被工程化以包含异源基因，包括其他病毒，病原体，细胞基因，肿瘤抗原的基因，或编码来自不同RSV病毒株的基因的组合。