公开(公告)号：US20240219204A1

公开(公告)日：2024-07-04

申请号：US18396521

申请日：2023-12-26

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke TAMAI ,  Akira NODA

IPC: G01D3/032

CPC classification number: G01D3/032 ,  G01N30/86

Abstract: A measurement data analysis device analyzes measurement data of a sample obtained in an analyzer, and includes a noise variation estimator that estimates a noise variation coefficient, the noise variation coefficient being applied to a noise included in the measurement data by a frequency filter included in the analyzer, an acquirer that acquires the measurement data to which the frequency filter has been applied in the analyzer, and a calculator that estimates, with use of the noise variation coefficient, a noise intensity included in the measurement data obtained before the frequency filter is applied, and analyzes, based on the estimated noise intensity, the measurement data.

公开(公告)号：US20160231297A1

公开(公告)日：2016-08-11

申请号：US15022626

申请日：2013-10-16

Applicant: SHIMADZU CORPORATION

Inventor： Akira NODA ,  Yasuhiro MITO

IPC: G01N30/86

CPC classification number: G01N30/8689 ,  G01N30/74 ,  G01N30/8644 ,  G01N30/8693

Abstract: For vector A which expresses an absorption spectrum of a target component, vector F orthogonal to vector A is designated as a filter for extracting an impurity superposed on the target component on a chromatogram. For vector I which expresses a measured spectrum obtained by a chromatographic analysis performed on a sample, the inner product of vectors I and F is defined as an index value u of the amount of impurity. If an impurity is present, a peak-like waveform appears on a graph which shows a temporal change in the index value u for the measured spectrum obtained at each point in time of the measurement. By detecting this waveform, the presence or absence of the impurity can be correctly determined. The direction of vector F may be determined so that, when vector B which expresses a spectrum of the impurity is decomposed into vector Ba parallel to vector A and vector Bo orthogonal to vector A, vector F becomes nearly parallel to vector Bo (i.e. the cosine similarity index is maximized).

Abstract translation: 对于表示目标成分的吸收光谱的矢量A，与矢量A正交的矢量F被指定为用于提取叠加在目标成分上的杂质的滤色片。 对于表达通过对样品进行的色谱分析获得的测量光谱的载体I，将载体I和F的内积定义为杂质量的指标值u。 如果存在杂质，则在曲线上出现峰状波形，其显示了在测量的每个时间点获得的测量光谱的指标值u的时间变化。 通过检测该波形，可以正确地确定杂质的存在或不存在。 可以确定矢量F的方向，使得当将表示杂质的频谱的矢量B分解成与矢量A平行的矢量B和与矢量A正交的矢量Bo时，矢量F几乎平行于矢量Bo（即，余弦 相似性指数最大化）。

公开(公告)号：US20160224830A1

公开(公告)日：2016-08-04

申请号：US14917364

申请日：2013-09-09

Applicant: SHIMADZU CORPORATION

Inventor： Akira NODA ,  Hiroaki KOZAWA

IPC: G06K9/00

CPC classification number: G06K9/00516 ,  G01N30/8634 ,  G06K9/0053

Abstract: For a signal waveform to be processed, the continuous wavelet transform is performed with various scale factors, and a wavelet coefficient at each point in time is calculated. On an image showing the strength of the wavelet coefficient with respect to the scale factor and time, ridge lines are detected, and based on these ridge lines, positive and negative peak candidates are extracted, after which an error in the position and width of the peak due to the influence of a neighboring peak is corrected. Subsequently, the degree of non-symmetry of the peak shape or other features are examined to remove false negative peaks due to negative peak artifacts. Subsequently, a true peak cluster, a false peak cluster resulting from the removal of high-frequency components of a high-frequency noise or other causes, and other kinds of peaks are identified, and the obtained result is used to remove false peaks.

Abstract translation: 对于要处理的信号波形，以各种比例因子执行连续小波变换，并计算每个时间点的小波系数。 在显示相对于比例因子和时间的小波系数的强度的图像上，检测脊线，并且基于这些脊线，提取正和负峰值候选，之后，位置和宽度的误差 校正由于相邻峰值的影响引起的峰值。 随后，检查峰形或其他特征的非对称度以消除由于负峰值伪影导致的假负峰。 随后，识别真正的峰集群，由去除高频噪声的高频分量或其他原因导致的假峰集，以及其他种类的峰，并且获得的结果用于去除假峰。

公开(公告)号：US20160011408A1

公开(公告)日：2016-01-14

申请号：US14773057

申请日：2013-03-08

Applicant: SHIMADZU CORPORATION

Inventor： Akira NODA

IPC: G02B21/36 ,  G01J3/10 ,  G01J3/02 ,  G01J3/453

CPC classification number: G02B21/361 ,  G01J3/0248 ,  G01J3/0275 ,  G01J3/0289 ,  G01J3/108 ,  G01J3/28 ,  G01J3/453 ,  G01N21/35 ,  G01N2021/3595 ,  G02B21/365 ,  G06K9/0014 ,  G06K9/6202 ,  G06T7/0004 ,  G06T7/11 ,  G06T2207/10048 ,  G06T2207/10056 ,  G06T2207/20056 ,  G06T2207/30164

Abstract: Provided is an analysis target region setting apparatus that can accurately set an analysis target region, based on an observation image of a sample obtained with an optical microscope and the like irrespective of texture on the sample surface when the analysis target region is set therein. The analysis target region setting apparatus according to the present invention divides the observation image into a plurality of sub-regions based on pixel information on each pixel constituting the observation image. Subsequently, consolidation information on each sub-region is calculated, and two adjacent sub-regions themselves are consolidated based on the consolidation information. According to this, it is possible to divide the observation image into sub-regions having similar pixel information with a disregard of noise attributed to the shape of a surface and the like. A user designates one sub-region from among the sub-regions finally obtained, as the analysis target region.

Abstract translation: 提供一种分析对象区域设定装置，其能够在设定分析对象区域时，基于用光学显微镜等获得的样本的观察图像来准确地设定分析对象区域，而与样本表面的纹理无关。 根据本发明的分析对象区域设定装置，根据构成观察图像的各像素的像素信息，将观察图像分割为多个子区域。 随后，计算每个子区域的合并信息，并且基于合并信息来合并两个相邻的子区域本身。 据此，可以将观察图像分割成具有类似像素信息的子区域，而不考虑由于表面形状等引起的噪声。 用户从最终获得的子区域中指定一个子区域作为分析目标区域。

公开(公告)号：US20140129169A1

公开(公告)日：2014-05-08

申请号：US13668770

申请日：2012-11-05

Applicant: SHIMADZU CORPORATION

Inventor： Akira NODA

IPC: G01N30/86

CPC classification number: G01N30/8665 ,  G01N30/8644

Abstract: Before executing a search for optimal correspondence relationship with a coarse-to-fine DP (dynamic programming) algorithm using time information of peaks appearing in a chromatogram as input data, a simplified linear correction is executed based on detection of start point and end point of the section in which the peaks are present. It is sufficient to correct only nonlinear time deviations in coarse-to-fine DP, and the space to be searched is thus narrowed down. In addition, in coarse stage DP, the number of pieces of data to be processed is reduced by selecting peaks based on peak intensity. Between coarse stage DP and fine stage DP, local inappropriate matching is eliminated by performing filtering processing in accordance with trend of time deviations over the entire chromatogram. The space to be searched in fine stage DP becomes narrow, which reduces the number of candidates to be searched and shortens the calculation time.

Abstract translation: 在使用以色谱图中出现的峰值的时间信息作为输入数据的粗略到精细DP（动态规划）算法执行最佳对应关系的搜索之前，基于检测到的起点和终点执行简化的线性校正 存在峰的部分。 仅修正粗略到精细DP中的非线性时间偏差就足够了，因此要搜索的空间变窄。 此外，在粗阶段DP中，通过基于峰值强度选择峰值来减少要处理的数据块数。 在粗级DP和精细级DP之间，通过根据整个色谱图上的时间偏差趋势执行滤波处理来消除局部不适当匹配。 在精细阶段DP中搜索的空间变窄，这减少了要搜索的候选人的数量并缩短了计算时间。