公开(公告)号：US20180321200A1

公开(公告)日：2018-11-08

申请号：US16035770

申请日：2018-07-16

Applicant: SHIMADZU CORPORATION

Inventor： Yasuhiro MITO ,  Etsuho KAMATA ,  Hiroshi MIURA ,  Kenichi MISHIMA ,  Toshinobu YANAGISAWA

IPC: G01N30/80 ,  B01D15/08 ,  G01N30/82

CPC classification number: G01N30/80 ,  B01D15/08 ,  G01N30/74 ,  G01N30/82 ,  G01N30/8631 ,  G01N2030/027

Abstract: A preparative separation chromatograph system having a column for temporally separating components in a sample and for discharging an eluate fluid with the components, a detector for obtaining an absorbance spectrum of the eluate fluid, and a fraction collector for continuously creating a chromatogram. The system further includes: a peak section determiner; a differential value determiner for calculating a differential spectrum value and for determining whether or not the absolute value of the differential spectrum value is equal to or less than a predetermined value; and a fraction collector controller for controlling the fraction collector so as to fractionate the eluate fluid during a period of time for which it is determined that the chromatogram peak of the target component is present and for which it is also determined the absolute value of the differential spectrum value is equal to or less than the predetermined value.

公开(公告)号：US20160216240A1

公开(公告)日：2016-07-28

申请号：US14915794

申请日：2013-09-02

Applicant: SHIMADZU CORPORATION

Inventor： Etsuho KAMATA ,  Toshinobu YANAGISAWA ,  Yasuhiro MITO ,  Kenichi MISHIMA

IPC: G01N30/86 ,  G01N30/74

CPC classification number: G01N30/8634 ,  G01N30/74

Abstract: A data processing system for a chromatograph including a standard sample data storage section; a standard sample sensitivity factor calculator; a post-correction standard sample chromatogram strength calculator; a specific designated retention time and specific designated wavelength setter; a measurement sample data storage section; a measurement sample sensitivity factor calculator; and a post-correction measurement sample chromatogram creator.

Abstract translation: 一种用于色谱仪的数据处理系统，包括标准样品数据存储部分; 标准样本敏感度因子计算器; 校正后标准样品色谱图强度计算器; 具体指定保留时间和具体指定波长设定器; 测量样本数据存储部分; 测量样本灵敏度因子计算器; 和校正后测量样品色谱图创建器。

公开(公告)号：US20160231297A1

公开(公告)日：2016-08-11

申请号：US15022626

申请日：2013-10-16

Applicant: SHIMADZU CORPORATION

Inventor： Akira NODA ,  Yasuhiro MITO

IPC: G01N30/86

CPC classification number: G01N30/8689 ,  G01N30/74 ,  G01N30/8644 ,  G01N30/8693

Abstract: For vector A which expresses an absorption spectrum of a target component, vector F orthogonal to vector A is designated as a filter for extracting an impurity superposed on the target component on a chromatogram. For vector I which expresses a measured spectrum obtained by a chromatographic analysis performed on a sample, the inner product of vectors I and F is defined as an index value u of the amount of impurity. If an impurity is present, a peak-like waveform appears on a graph which shows a temporal change in the index value u for the measured spectrum obtained at each point in time of the measurement. By detecting this waveform, the presence or absence of the impurity can be correctly determined. The direction of vector F may be determined so that, when vector B which expresses a spectrum of the impurity is decomposed into vector Ba parallel to vector A and vector Bo orthogonal to vector A, vector F becomes nearly parallel to vector Bo (i.e. the cosine similarity index is maximized).

Abstract translation: 对于表示目标成分的吸收光谱的矢量A，与矢量A正交的矢量F被指定为用于提取叠加在目标成分上的杂质的滤色片。 对于表达通过对样品进行的色谱分析获得的测量光谱的载体I，将载体I和F的内积定义为杂质量的指标值u。 如果存在杂质，则在曲线上出现峰状波形，其显示了在测量的每个时间点获得的测量光谱的指标值u的时间变化。 通过检测该波形，可以正确地确定杂质的存在或不存在。 可以确定矢量F的方向，使得当将表示杂质的频谱的矢量B分解成与矢量A平行的矢量B和与矢量A正交的矢量Bo时，矢量F几乎平行于矢量Bo（即，余弦 相似性指数最大化）。

公开(公告)号：US20160033457A1

公开(公告)日：2016-02-04

申请号：US14772432

申请日：2014-02-12

Applicant: SHIMADZU CORPORATION

Inventor： Kenichi MISHIMA ,  Etsuho KAMATA ,  Hiroshi MIURA ,  Yasuhiro MITO ,  Toshinobu YANAGISAWA

IPC: G01N30/74 ,  G01N30/86

Abstract: Regarding a chromatogram data processing device configured to process three-dimensional chromatogram data collected on a target sample in which dimensions are made up of time, wavelength, and absorbance, and the chromatogram data processing device includes a differential spectrum generating means configured to generate a differential spectrum that represents a change in a wavelength differential coefficient, which is a differential coefficient in a wavelength direction in a predetermined wavelength range, based on the three-dimensional chromatogram data, with respect to an absorbance spectrum representing a relation of the wavelength and the absorbance at each time in an entire temporal range or a predetermined temporal range, and a determination means configured to determine whether or not one or plural other components are included in a peak of a target component, based on a temporal change in a waveform of the differential spectrum, so that the determination on whether or not a target sample includes impurities can be performed with high accuracy without the requirement of complicated computation processing.

Abstract translation: 关于色谱图数据处理装置，被配置为处理收集在尺寸由时间，波长和吸光度构成的目标样品上的三维色谱图数据，并且色谱图数据处理装置包括差分光谱产生装置，其被配置为产生差分 光谱，其表示波长微分系数的变化，该波长微分系数是基于三维色谱图数据在预定波长范围内的波长方向上的微分系数，相对于表示波长和吸光度的关系的吸收光谱 在每个时间处于整个时间范围或预定时间范围内的确定装置，以及确定装置，被配置为基于差分波形的时间变化来确定是否将一个或多个其它分量包括在目标分量的峰值中 频谱，以便确定是否targ 可以高精度地执行杂质，而不需要复杂的计算处理。

公开(公告)号：US20160018370A1

公开(公告)日：2016-01-21

申请号：US14772487

申请日：2013-03-04

Applicant: SHIMADZU CORPORATION

Inventor： Yasuhiro MITO ,  Etsuho KAMATA ,  Hiroshi MIURA ,  Kenichi MISHIMA ,  Toshinobu YANAGISAWA

IPC: G01N30/80 ,  B01D15/08

CPC classification number: G01N30/80 ,  B01D15/08 ,  G01N30/74 ,  G01N30/82 ,  G01N30/8631 ,  G01N2030/027

Abstract: A preparative separation chromatograph system having a column for temporally separating components in a sample and for discharging an eluate fluid with the components, a detector for obtaining an absorbance spectrum of the eluate fluid, and a fraction collector for continuously creating a chromatogram. The system further includes: a peak section determiner; a differential value determiner for calculating a differential spectrum value and for determining whether or not the absolute value of the differential spectrum value is equal to or less than a predetermined value; and a fraction collector controller for controlling the fraction collector so as to fractionate the eluate fluid during a period of time for which it is determined that the chromatogram peak of the target component is present and for which it is also determined the absolute value of the differential spectrum value is equal to or less than the predetermined value.

Abstract translation: 一种制备型分离色谱系统，其具有用于在时间上分离样品中的组分和用该组分排出洗脱液的柱，用于获得洗脱液的吸收光谱的检测器和用于连续产生色谱图的级分收集器。 该系统还包括：峰值段确定器; 差分值确定器，用于计算差分谱值并确定差分谱值的绝对值是否等于或小于预定值; 以及馏分收集器控制器，用于控制馏分收集器，以便在确定目标成分的色谱峰值存在并且还确定差分的绝对值的时间段内分馏洗脱液 光谱值等于或小于预定值。

公开(公告)号：US20160209380A1

公开(公告)日：2016-07-21

申请号：US14914706

申请日：2014-05-20

Applicant: SHIMADZU CORPORATION

Inventor： Kenichi MISHIMA ,  Etsuho KAMATA ,  Hiroshi MIURA ,  Yasuhiro MITO ,  Toshinobu YANAGISAWA

IPC: G01N30/86 ,  G01N30/74

Abstract: A chromatogram data processing system having an impurity detector including a differential chromatogram creator, a purity curve creator and a determiner. The differential chromatogram creator calculates a differential coefficient of an absorbance spectrum with respect to wavelength at a local maximum or local minimum absorption wavelength of the target component, and creates a differential chromatogram which shows a temporal change of the differential coefficient. The purity curve creator creates a purity curve which shows a temporal change of the difference between the degree of similarity of a spectrum on the target peak to a reference spectrum and a threshold of the degree of similarity which is determined taking into account the influence of noise components. The differential chromatogram and the purity curve are displayed on a display unit in a superposed form on a wavelength chromatogram created by a wavelength chromatogram creator.

Abstract translation: 具有杂质检测器的色谱图数据处理系统，包括差示色谱图创建器，纯度曲线创建器和确定器。 差示色谱图创建器计算相对于目标成分的局部最大或局部最小吸收波长的波长的吸收光谱的微分系数，并产生显示微分系数的时间变化的差示色谱图。 纯度曲线创建者产生纯度曲线，其显示目标峰值上的光谱与参考光谱的相似度之间的差异的时间变化以及考虑到噪声的影响而确定的相似度的阈值 组件。 差示色谱图和纯度曲线以叠加形式显示在由波长色谱图创建器创建的波长色谱图上的显示单元上。

公开(公告)号：US20160169849A1

公开(公告)日：2016-06-16

申请号：US14908248

申请日：2013-07-29

Applicant: SHIMADZU CORPORATION

Inventor： Etsuho KAMATA ,  Toshinobu YANAGISAWA ,  Yasuhiro MITO ,  Kenichi MISHIMA

IPC: G01N30/86

Abstract: A system for creating a chromatogram based on a temporal change of a spectrum obtained within a predetermined wavelength range including a target wavelength, the system including a post-correction chromatogram display section for displaying a post-correction chromatogram obtained by multiplying a chromatogram at the designated wavelength by a sensitivity factor obtained by dividing the intensity of the designated-time spectrum at the target wavelength by the intensity of the designated-time spectrum at the designated wavelength, and for changing the display to a post-correction chromatogram corresponding to the latest values of the designated time point and the designated wavelength when one or both of the designated time point and the designated wavelength are changed.

Abstract translation: 一种用于基于在包括目标波长的预定波长范围内获得的光谱的时间变化创建色谱图的系统，所述系统包括校正后色谱图显示部分，用于显示通过将指定的色谱图相乘得到的校正后色谱图 通过将目标波长处的指定时间光谱的强度除以指定波长的指定时间光谱的强度而获得的灵敏度因子，并将显示改变为对应于最新值的校正后色谱图 并且指定的时间点和指定波长中的一个或两个改变时，指定的时间点和指定的波长。

公开(公告)号：US20160169848A1

公开(公告)日：2016-06-16

申请号：US14902638

申请日：2013-08-05

Applicant: SHIMADZU CORPORATION

Inventor： Etsuho KAMATA ,  Toshinobu YANAGISAWA ,  Yasuhiro MITO ,  Kenichi MISHIMA

IPC: G01N30/86

CPC classification number: G01N30/8634

Abstract: There are provided a data processing device for chromatograph and a data processing method for chromatograph which allow a peak to be desirably checked. A peak (correction target peak (P1)) whose intensity exceeds a predetermined threshold in a chromatogram at a target wavelength (X1) is corrected based on correction reference values (height (H1) and area (A1) of a peak (P11)) and a sensitivity coefficient (R=I1/I2), and the chromatogram after correction is displayed or printed. Therefore, even if the correction target peak (P1) is saturated, display or printing may be performed in a state where correction has been performed so that the chromatogram at the peak (P1) is not cut off in the middle. Accordingly, at the time of display or printing of the chromatogram, a fine peak may be prevented from becoming too small, and also the correction target peak (P1) may be prevented from being cut off in the middle, and thus the peaks may be desirably checked.

Abstract translation: 提供了用于色谱的数据处理装置和用于色谱的数据处理方法，其允许期望检查峰。 基于校正基准值（峰值的高度（H1）和面积（A1））校正在目标波长（X1）的色谱图中强度超过预定阈值的峰值（校正目标峰值（P1））） 和灵敏度系数（R = I1 / I2），校正后的色谱图显示或打印。 因此，即使校正目标峰值（P1）饱和，也可以在执行校正的状态下执行显示或打印，使得峰值（P1）的色谱图在中间不被切断。 因此，在显示或打印色谱图时，可以防止细小的峰变得太小，并且还可以防止在中间切断校正目标峰（P1），因此峰可以是 期望检查。