公开(公告)号：US4377594A

公开(公告)日：1983-03-22

申请号：US267249

申请日：1981-05-26

申请人： Hitoshi Takita ,  Yutaka Mukaida ,  Sakuo Noda ,  Hidetoshi Kobayashi

发明人： Hitoshi Takita ,  Yutaka Mukaida ,  Sakuo Noda ,  Hidetoshi Kobayashi

IPC分类号： A61K31/195 ,  C07C101/30

CPC分类号： A61K31/195 ,  Y10S514/825 ,  Y10S514/826

摘要： A novel compound of 4-[N-(substituted-benzylidene)aminomethyl]cyclohexane-1-carboxylic acid or a salt or an ester thereof which has specific pharmacologic activities, a method for preparing thereof and a pharmaceutical composition comprising thereof as an active ingredient are provided.

摘要翻译： 具有特定药理活性的4- [N-（取代 - 亚苄基）氨基甲基]环己烷-1-羧酸或其盐或其酯的新型化合物，其制备方法和包含其作为活性成分的药物组合物 被提供。

公开(公告)号：US4997850A

公开(公告)日：1991-03-05

申请号：US507839

申请日：1990-04-12

申请人： Fumihiko Kimura ,  Yutaka Mukaida ,  Koju Watanabe

发明人： Fumihiko Kimura ,  Yutaka Mukaida ,  Koju Watanabe

IPC分类号： A61K20060101 ,  A61K31/11 ,  A61K31/19 ,  A61K31/195 ,  A61K31/215 ,  A61K31/22 ,  A61K31/235 ,  A61P43/00

CPC分类号： A61K31/11 ,  A61K31/19 ,  A61K31/215 ,  A61K31/22 ,  Y10S514/825

摘要： The present invention discloses a method for treating a patient suffering from osteoarthritis comprising administering a physiologically effective amount of pharmaceutical composition containing at least one compound, as an active ingredient, represented by the formula (I): ##STR1## wherein R represents a hydrogen atom or an acyl group; X represents a CHO group, a COOH group, a physiologically acceptable salt thereof or a CH(OR').sub.2 group wherein R' represents an acyl group.