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公开(公告)号:US20180345047A1
公开(公告)日:2018-12-06
申请号:US15552506
申请日:2016-02-25
申请人: Yeda Research and Development Co. Ltd. , Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
发明人: Valery KRIZHANOVSKY , Reut YOSEF , Noam PILPEL , Ittai BEN-PORATH , Liat DASSA , Ronit AMIEL-TOKARSKY
CPC分类号: A61Q7/00 , A61K8/606 , A61K31/11 , A61K31/34 , A61K31/404 , A61K31/635 , A61K31/713
摘要: A method of promoting hair growth or reducing hair loss in a subject is disclosed. The method comprises contacting the scalp and skin region in which there is desire for hair growth of the subject with an effective amount of at least one agent which down-regulates an activity and/or an amount of a protein selected from the group consisting of p21, Bcl-xL and Bcl-w. Compositions capable of same are also disclosed.
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2.
公开(公告)号:US20180344680A1
公开(公告)日:2018-12-06
申请号:US16060742
申请日:2016-12-07
发明人: Donna D. Zhang , Georg T. Wondrak
IPC分类号: A61K31/26 , A61K31/11 , A61P17/02 , A61K31/522 , A61K31/4709 , A61K31/4365 , A61K31/235 , A61K38/18
CPC分类号: G01N33/6872 , A61K9/0014 , A61K31/05 , A61K31/11 , A61K31/12 , A61K31/192 , A61K31/232 , A61K31/26 , A61K31/277 , A61K31/343 , A61K31/4365 , A61K31/4709 , A61K31/522 , A61K31/616 , A61K38/00 , A61K2300/00
摘要: Compositions and methods are provided for treating, ameliorating, and preventing diabetes-related skin ulcers in a mammalian subject comprising administering to the subject an effective amount of an NRF2 activating agent.
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公开(公告)号:US20180325859A1
公开(公告)日:2018-11-15
申请号:US15527873
申请日:2015-11-19
申请人: GALDERMA SA
发明人: Jean-Paul CHAPPUIS , Jean JACOVELLA
IPC分类号: A61K31/327 , A61K31/7048 , A61K31/192 , A61K31/203 , A61K31/07 , A61K9/00 , A61P17/10
CPC分类号: A61K31/327 , A61K9/0014 , A61K31/07 , A61K31/11 , A61K31/192 , A61K31/203 , A61K31/232 , A61K31/366 , A61K31/40 , A61K31/4436 , A61K31/7048 , A61P17/10 , A61K2300/00
摘要: Compositions including a compound of the family of avermectins, preferably ivermectin, and an agonist compound for at least one of the retinoic acid receptors are described. The compositions are in particular used in the treatment of acne.
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4.
公开(公告)号:US20180235859A1
公开(公告)日:2018-08-23
申请号:US15962436
申请日:2018-04-25
申请人: DermaMedics, LLC
发明人: Bryan B. Fuller
IPC分类号: A61K8/37 , A61K31/19 , A61K9/00 , A61K31/222 , A61K31/60 , A61K8/33 , A61Q19/02 , A61Q19/08 , A61K8/25 , A61K8/34 , A61K8/35 , A61K8/368 , A61K31/11 , A61K31/085 , A61K9/20 , A61K9/06 , A61K47/24 , A61K9/08
CPC分类号: A61K8/37 , A61K8/25 , A61K8/33 , A61K8/34 , A61K8/347 , A61K8/35 , A61K8/368 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K9/08 , A61K9/2059 , A61K9/2063 , A61K31/085 , A61K31/11 , A61K31/19 , A61K31/222 , A61K31/60 , A61K47/24 , A61Q19/02 , A61Q19/08
摘要: Compositions containing an effective dermatological disease-treating or dermatological condition-treating active agent and a pharmaceutically-acceptable carrier or vehicle are disclosed. Methods of using the compositions are also disclosed.
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公开(公告)号:US10016380B2
公开(公告)日:2018-07-10
申请号:US15484827
申请日:2017-04-11
申请人: Lanny Leo Johnson
发明人: Lanny Leo Johnson
CPC分类号: A61K31/192 , A01N31/02 , A01N35/04 , A01N37/40 , A01N43/16 , A23B7/154 , A23L3/34635 , A23L3/3481 , A23L3/349 , A23L3/3508 , A23L3/3544 , A23V2002/00 , A61K8/14 , A61K8/347 , A61K8/368 , A61K8/602 , A61K9/0014 , A61K9/08 , A61K9/127 , A61K31/11 , A61K31/352 , A61K31/7048 , A61K45/06 , A61L2/0088 , A61L2/18 , A61L2/235 , A61L15/44 , A61L15/46 , A61L26/0066 , A61L2202/24 , A61L2202/26 , A61L2300/21 , A61L2300/404 , A61Q17/005 , A61Q19/08 , Y02A40/944 , Y02A50/473 , Y02A50/478 , A61K2300/00
摘要: This disclosure provides generally for antimicrobial compositions and methods of use comprising an anthocyanin, an anthocyanidin or metabolites thereof. Methods for promoting healing of a wound using these compositions are also disclosed. These compositions have broad spectrum antimicrobial activity and are safe for human and animal uses. Further, these compositions are safe for medical uses and industrial uses as antiseptic preparations to reduce or prevent microbial growth, including killing bacterial biofilms.
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公开(公告)号:US10004705B2
公开(公告)日:2018-06-26
申请号:US15789759
申请日:2017-10-20
申请人: Lanny Leo Johnson
发明人: Lanny Leo Johnson
IPC分类号: A61K31/192 , A61L2/18 , A61L15/44 , A01N31/02 , A61K31/11 , A61K9/127 , A61K9/08 , A61K9/14 , A61K9/00
CPC分类号: A61K31/192 , A01N31/02 , A01N35/04 , A01N37/40 , A01N43/16 , A23B7/154 , A23L3/34635 , A23L3/3481 , A23L3/349 , A23L3/3508 , A23L3/3544 , A23V2002/00 , A61K8/14 , A61K8/347 , A61K8/368 , A61K8/602 , A61K9/0014 , A61K9/08 , A61K9/127 , A61K31/11 , A61K31/352 , A61K31/7048 , A61K45/06 , A61L2/0088 , A61L2/18 , A61L2/235 , A61L15/44 , A61L15/46 , A61L26/0066 , A61L2202/24 , A61L2202/26 , A61L2300/21 , A61L2300/404 , A61Q17/005 , A61Q19/08 , Y02A40/944 , Y02A50/473 , Y02A50/478 , A61K2300/00
摘要: This disclosure provides generally for antimicrobial compositions and methods of use comprising an anthocyanin, an anthocyanidin or metabolites thereof. Methods for promoting healing of a wound using these compositions are also disclosed. These compositions have broad spectrum antimicrobial activity and are safe for human and animal uses. Further, these compositions are safe for medical uses and industrial uses as antiseptic preparations to reduce or prevent microbial growth, including killing bacterial biofilms.
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公开(公告)号:US20180147223A1
公开(公告)日:2018-05-31
申请号:US15362959
申请日:2016-11-29
申请人: Prime Bio, Inc
发明人: Bal Ram Singh , Kruti Patel
IPC分类号: A61K31/704 , A61K31/366 , A61K31/353 , A61K31/11 , A61K31/122 , A61K31/385 , A61K31/4745
CPC分类号: A61K31/704 , A61K31/11 , A61K31/122 , A61K31/353 , A61K31/366 , A61K31/385 , A61K31/4745 , Y02A50/469
摘要: Present invention discloses a method of treating an individual suffering from botulism by inhibiting botulinum neurotoxins.
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公开(公告)号:US09981048B2
公开(公告)日:2018-05-29
申请号:US14177928
申请日:2014-02-11
发明人: Ira Jacob Fox , Aaron W. Bell , Taichiro N. Nishikawa , Alejandro Soto-Gutierrez , Yoram Vodovotz
IPC分类号: A61K48/00 , A61K31/343 , C07K14/47 , A61K45/06 , A61K31/05 , A61K31/085 , A61K31/11 , C12N15/86
CPC分类号: A61K48/005 , A61K31/05 , A61K31/085 , A61K31/11 , A61K31/343 , A61K45/06 , C07K14/4702 , C12N15/86 , C12N2750/14141 , C12N2750/14171 , A61K2300/00
摘要: The presently disclosed invention is directed to the discovery that hepatocyte nuclear factor 4 alpha (HNF4α; also known as NR2A1), a transcription factor, reverses hepatocyte dysfunction in an animal model of cirrhosis, resulting in improvement in hepatic function, treatment of cirrhosis, and prolonged survival.
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9.
公开(公告)号:US20180133223A1
公开(公告)日:2018-05-17
申请号:US15800386
申请日:2017-11-01
申请人: Curis, Inc.
发明人: Ali Fattaey , Garrett W. Rhyasen
IPC分类号: A61K31/5377 , A61P35/00 , A61K31/635 , A61K31/404 , A61K31/166 , A61K31/352 , A61K31/353 , A61K31/255 , A61K31/11 , A61P35/02
CPC分类号: A61K31/5377 , A61K31/11 , A61K31/166 , A61K31/255 , A61K31/352 , A61K31/353 , A61K31/404 , A61K31/635 , A61P35/00 , A61P35/02
摘要: The invention provides a method of treating cancer in a subject in need thereof, comprising administering to the subject: (a) a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or an acyl group; and (b) a BCL-2 inhibitor; wherein the compound of Formula I or pharmaceutically acceptable salt thereof and a BCL-2 inhibitor are administered in amounts which in combination are therapeutically effective. The invention further provides a pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, a BCL-2 inhibitor and a pharmaceutically acceptable carrier or excipient.
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公开(公告)号:US20180133171A1
公开(公告)日:2018-05-17
申请号:US15861440
申请日:2018-01-03
发明人: Jin-Won Hyun , Hee-Kyoung Kang , Nam-Ho Lee , Sung-Wook Chae
摘要: There is provided a composition including a 3-bromo-4,5-dihydroxybenzaldehyde (BDB) for protecting human skin keratinocyte from ultraviolet, in which the BDB has a photo-protective effect against cell damage caused by ultraviolet in human HaCaT skin keratinocyte, activity of removing a free radical, and ultraviolet absorption activity, and inhibits formations of lipid peroxidation and protein carbonyl, inhibits DNA damage, protects a cell, and thereby exhibits cell protective activity. Thus, the BDB decreases apoptosis induced by ultraviolet, and then protect a cell to recover cell viability.
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