公开(公告)号：US07384786B2

公开(公告)日：2008-06-10

申请号：US10892518

申请日：2004-07-15

申请人： Toby Freyman ,  Maria Palasis ,  Mark Ungs

发明人： Toby Freyman ,  Maria Palasis ,  Mark Ungs

IPC分类号： C12N5/00 ,  A61K9/00

CPC分类号： C12N5/00 ,  A61K35/12 ,  A61L27/3604 ,  A61L27/367 ,  A61L27/54 ,  A61L27/60 ,  A61L2300/252 ,  A61L2300/254 ,  A61L2300/256 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/43 ,  A61L2300/604 ,  C12N5/0068 ,  C12N5/0657 ,  C12N5/0698 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2533/74 ,  C12N2533/92 ,  C12N2535/10

摘要： The present invention relates to a biocompatible, three-dimensional scaffold useful to grow cells and to regenerate or repair tissue in predetermined orientations. The scaffold is particularly useful for regeneration and repair of cardiac tissue. The scaffold contains layers of alternating A-strips and S-strips, wherein the A-strips within each layer are aligned parallel to each other and preferentially promote cellular attachment over attachment to the S-strips. Methods of producing and implanting the scaffold are also provided.

摘要翻译： 本发明涉及生物相容的三维支架，其可用于生长细胞并且以预定取向再生或修复组织。 支架对心脏组织的再生和修复特别有用。 支架包含交替的A带和S带的层，其中每层内的A带彼此平行对准，并优先促进通过附着到S带的细胞附着。 还提供了生产和植入支架的方法。