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21.发明授权Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient 有权具有官能化聚乙二醇赋形剂的药用气溶胶组合物公开(公告)号：US07718162B2
公开(公告)日：2010-05-18
申请号：US10327200
申请日：2002-12-20
申请人： James S. Stefely , Daniel C. Duan
发明人： James S. Stefely , Daniel C. Duan
CPC分类号： A61K9/008 , A61K47/10 , A61K47/541 , A61K47/60
摘要： The invention comprises a medicinal aerosol composition comprising a propellant, an excipient comprising a functionalized polyethyleneglycol, and a drug. The invention also comprises particulate medicinal compositions comprising particles with a mean mass aerodynamic diameter of less than about 10 microns that incorporate an excipient comprising a functionalized polyethyleneglycol.
摘要翻译： 本发明包括药物气溶胶组合物，其包含推进剂，包含官能化聚乙二醇的赋形剂和药物。 本发明还包括颗粒药物组合物，其包含平均质量空气动力学直径小于约10微米的颗粒，其掺入包含官能化聚乙二醇的赋形剂。
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22.发明授权Biocompatible compounds for sustained release pharmaceutical drug delivery systems 失效用于持续释放药物输送系统的生物相容性化合物公开(公告)号：US07687054B2
公开(公告)日：2010-03-30
申请号：US10078805
申请日：2002-02-18
CPC分类号： A61K9/0075 , A61K9/008 , A61K9/1647 , A61K47/593
摘要： Methods, compounds, and medicinal formulations utilizing biocompatible polymers for delivery of a drug, particularly for solubilizing, stabilizing and/or providing sustained release of drug from topical, implantable, and inhalation systems. Many of the methods, compounds, and medicinal formulations are particularly suitable for oral and/or nasal inhalation and use polymers of the formula —[X—R1—C(O)]— wherein each R1 is an independently selected organic group that links the —X— group to the carbonyl group, and each X is independently oxygen, sulfur, or catenary nitrogen.
摘要翻译： 方法，化合物和利用生物相容性聚合物递送药物的药物制剂，特别是用于增溶，稳定和/或从局部，可植入和吸入系统中持续释放药物。 许多方法，化合物和药物制剂特别适用于口服和/或鼻吸入并使用下式的聚合物 - [X-R 1 -C（O）] - ，其中每个R 1是独立选择的有机基团，其连接 -X-基团，并且每个X独立地为氧，硫或链状氮。
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23.发明授权Stabilized dispersions comprising excipient surface-modified organic nanoparticles and medicament particles 有权包含赋形剂表面改性的有机纳米颗粒和药物颗粒的稳定分散体公开(公告)号：US07425582B2
公开(公告)日：2008-09-16
申请号：US11463616
申请日：2006-08-10
CPC分类号： A61K47/34 , A61K9/008 , A61K47/06 , A61K47/32 , Y10S514/844 , Y10S514/938 , Y10S977/773 , Y10S977/786 , Y10S977/915
摘要： In one aspect, the invention provides a stable dispersion comprising a continuous phase comprising a continuous liquid phase and a plurality of organic nanoparticles; and a dispersed phase comprising particles dispersed in the continuous phase.
摘要翻译： 在一个方面，本发明提供了包含连续相的稳定分散体，所述连续相包含连续液相和多个有机纳米颗粒; 以及包含分散在连续相中的颗粒的分散相。
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公开(公告)号：US07141612B2
公开(公告)日：2006-11-28
申请号：US10334963
申请日：2002-12-31
摘要： The invention relates to stabilized gas-in-liquid dispersions or foams containing a liquid continuous phase, a dispersed gas phase, and surface-modified fullerenes, dendrimers, organic polymeric microspheres, or combinations thereof.
摘要翻译： 本发明涉及包含液体连续相，分散气相和表面改性的富勒烯，树枝状大分子，有机聚合物微球或其组合的稳定化的液体 - 液体分散体或泡沫。
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公开(公告)号：US07001580B2
公开(公告)日：2006-02-21
申请号：US10335495
申请日：2002-12-31
IPC分类号： C01B31/00
CPC分类号： B01F17/0085 , B01F17/0014 , B01F17/005 , B82Y30/00 , B82Y40/00 , C01B32/15 , C08J3/11 , Y10S423/39 , Y10S423/40
摘要： The invention is related to emulsions containing surface-modified organic molecules, organic polymeric microspheres, or combinations thereof.
摘要翻译： 本发明涉及含有表面改性有机分子，有机聚合物微球或其组合的乳液。
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公开(公告)号：US06416742B1
公开(公告)日：2002-07-09
申请号：US09634406
申请日：2000-08-09
申请人： James S. Stefely , David W. Schultz , Luke E. Schallinger , Craig A. Perman , Chester L. Leach , Daniel C. Duan
发明人： James S. Stefely , David W. Schultz , Luke E. Schallinger , Craig A. Perman , Chester L. Leach , Daniel C. Duan
IPC分类号： A61K912
CPC分类号： A61K9/0075 , A61K9/008 , A61K9/1647 , A61K47/593
摘要： Methods, compounds, and medicinal formulations utilizing biocompatible polymers for delivery of a drug, particularly for solubilizing, stabilizing and/or providing sustained release of drug from topical, implantable, and inhalation systems. Many of the methods, compounds, and medicinal formulations are particularly suitable for oral and/or nasal inhalation and use polymers of the formula —[X—R1—C(O)]— wherein each R1 is an independently selected organic group that links the —X— group to the carbonyl group, and each X is independently oxygen, sulfur, or catenary nitrogen.
摘要翻译： 方法，化合物和利用生物相容性聚合物递送药物的药物制剂，特别是用于增溶，稳定和/或从局部，可植入和吸入系统中持续释放药物。 许多方法，化合物和药物制剂特别适用于口服和/或鼻吸入并使用下式的聚合物 - [X-R 1 -C（O）] - ，其中每个R 1是独立选择的有机基团，其连接 -X-基团，并且每个X独立地为氧，硫或链状氮。
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