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公开(公告)号：US07459146B2
公开(公告)日：2008-12-02
申请号：US10449443
申请日：2003-05-30
CPC分类号： A61K9/008 , A61K47/02 , B01F17/0078 , B01F17/0085 , B01J13/0095 , Y10S514/937
摘要： The invention relates to stabilized dispersions containing nanoparticles of use for the administration of medicaments. The dispersions comprise excipient nanoparticles, a dispersed phase comprising medicament and a continuous phase comprising propellant.
摘要翻译： 本发明涉及包含用于给药药物的纳米颗粒的稳定分散体。 分散体包括赋形剂纳米颗粒，包含药物的分散相和包含推进剂的连续相。
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公开(公告)号：US20080286362A1
公开(公告)日：2008-11-20
申请号：US11995845
申请日：2006-08-04
摘要： Powder compositions exhibiting improved flow properties. The compositions generally contain a bulk solid material in the form of a powder and surface-modified nanoparticles. Methods of improving the flow of powder compositions and devices and articles made using such compositions are also disclosed.
摘要翻译： 表现出改进的流动特性的粉末组合物。 组合物通常含有粉末形式的体固体材料和表面改性的纳米颗粒。 还公开了改善使用这种组合物制备的粉末组合物和装置和制品的流动的方法。
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3.发明授权Methods of treating mammals with stabilized particle dispersions containing excipient surface-modified nanoparticles 有权用含有赋形剂表面改性纳米粒子的稳定化颗粒分散体处理哺乳动物的方法公开(公告)号：US07476694B2
公开(公告)日：2009-01-13
申请号：US11463621
申请日：2006-08-10
CPC分类号： A61K47/34 , A61K9/008 , A61K47/06 , A61K47/32 , Y10S514/844 , Y10S514/938 , Y10S977/773 , Y10S977/786 , Y10S977/915
摘要： In one aspect, the invention provides a stable dispersion comprising a continuous phase comprising a continuous liquid phase and a plurality of organic nanoparticles; and a dispersed phase comprising particles dispersed in the continuous phase.
摘要翻译： 在一个方面，本发明提供了包含连续相的稳定分散体，所述连续相包含连续液相和多个有机纳米颗粒; 以及包含分散在连续相中的颗粒的分散相。
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公开(公告)号：US08062670B2
公开(公告)日：2011-11-22
申请号：US11995845
申请日：2006-08-04
摘要： Powder compositions exhibiting improved flow properties. The compositions generally contain a bulk solid material in the form of a powder and surface-modified nanoparticles. Methods of improving the flow of powder compositions and devices and articles made using such compositions are also disclosed.
摘要翻译： 表现出改进的流动特性的粉末组合物。 组合物通常含有粉末形式的体固体材料和表面改性的纳米颗粒。 还公开了改善使用这种组合物制备的粉末组合物和装置和制品的流动的方法。
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5.发明授权Stabilized dispersions comprising excipient surface-modified organic nanoparticles and medicament particles 有权包含赋形剂表面改性的有机纳米颗粒和药物颗粒的稳定分散体公开(公告)号：US07425582B2
公开(公告)日：2008-09-16
申请号：US11463616
申请日：2006-08-10
CPC分类号： A61K47/34 , A61K9/008 , A61K47/06 , A61K47/32 , Y10S514/844 , Y10S514/938 , Y10S977/773 , Y10S977/786 , Y10S977/915
摘要： In one aspect, the invention provides a stable dispersion comprising a continuous phase comprising a continuous liquid phase and a plurality of organic nanoparticles; and a dispersed phase comprising particles dispersed in the continuous phase.
摘要翻译： 在一个方面，本发明提供了包含连续相的稳定分散体，所述连续相包含连续液相和多个有机纳米颗粒; 以及包含分散在连续相中的颗粒的分散相。
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公开(公告)号：US07141612B2
公开(公告)日：2006-11-28
申请号：US10334963
申请日：2002-12-31
摘要： The invention relates to stabilized gas-in-liquid dispersions or foams containing a liquid continuous phase, a dispersed gas phase, and surface-modified fullerenes, dendrimers, organic polymeric microspheres, or combinations thereof.
摘要翻译： 本发明涉及包含液体连续相，分散气相和表面改性的富勒烯，树枝状大分子，有机聚合物微球或其组合的稳定化的液体 - 液体分散体或泡沫。
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公开(公告)号：US07001580B2
公开(公告)日：2006-02-21
申请号：US10335495
申请日：2002-12-31
IPC分类号： C01B31/00
CPC分类号： B01F17/0085 , B01F17/0014 , B01F17/005 , B82Y30/00 , B82Y40/00 , C01B32/15 , C08J3/11 , Y10S423/39 , Y10S423/40
摘要： The invention is related to emulsions containing surface-modified organic molecules, organic polymeric microspheres, or combinations thereof.
摘要翻译： 本发明涉及含有表面改性有机分子，有机聚合物微球或其组合的乳液。
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8.发明申请STABILIZED PARTICLE DISPERSIONS CONTAINING SURFACE-MODIFIED INORGANIC NANOPARTICLES 审中-公开含有表面改性无机纳米颗粒的稳定颗粒分散体公开(公告)号：US20080268062A1
公开(公告)日：2008-10-30
申请号：US12167714
申请日：2008-07-03
IPC分类号： A61K9/51
CPC分类号： B01F17/0078 , A61K9/10 , A61K47/02 , A61K47/24
摘要： This invention relates to particle-in-liquid dispersions containing surface-modified inorganic nanoparticles.
摘要翻译： 本发明涉及含有表面改性无机纳米粒子的粒子 - 液体分散体。
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公开(公告)号：US09072664B2
公开(公告)日：2015-07-07
申请号：US12992633
申请日：2009-04-17
CPC分类号： A61K9/0075
摘要： Powder drug compositions exhibiting improved flow properties are manufactured by spraying a suspension of surface-modified nanoparticles having an average particle size diameter of less than 100 nm in a dryable liquid carrier onto particles of a powder ingredient of a drug composition. The liquid carrier is rapidly dried so as to leave the nanoparticles on the powder. Other ingredients of the powder drug composition can also be added.
摘要翻译： 表现出改善的流动特性的粉末药物组合物是通过将平均粒度直径小于100nm的表面改性纳米颗粒的悬浮液在可干燥的液体载体中喷洒到药物组合物粉末成分的颗粒上而制成的。 液体载体被快速干燥，以使纳米颗粒留在粉末上。 还可以加入粉末药物组合物的其他成分。
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公开(公告)号：US20120132203A1
公开(公告)日：2012-05-31
申请号：US13320762
申请日：2010-05-18
申请人： Peter D. Hodson , Stephen W. Stein , Herbert C. Chiou , Zhaolin Wang , Thomas S. Robison , Michael K. Domroese , Blake D. Walburg
发明人： Peter D. Hodson , Stephen W. Stein , Herbert C. Chiou , Zhaolin Wang , Thomas S. Robison , Michael K. Domroese , Blake D. Walburg
IPC分类号： A61M15/00
CPC分类号： A61M15/0051 , A61M15/0005 , A61M15/0008 , A61M15/0021 , A61M15/0025 , A61M15/0026 , A61M15/0043 , A61M15/0045 , A61M15/0055 , A61M15/0065 , A61M15/0091 , A61M15/0096 , A61M2202/064 , A61M2205/0216 , A61M2205/0238 , A61M2205/19
摘要： Dry powder inhalers and dry powder inhaler storage cassettes including a compartment housing an elongate carrier preloaded with a plurality of doses of finely divided powder comprising a biologically active substance, the compartment being configured such that said preloaded doses are sealed within said compartment and such that the carrier may be advanced from the compartment to the chamber through an exit provided with a moisture barrier sealing system, wherein the moisture barrier sealing system is configured and arranged such that it is relaxable during advancement of the carrier, said sealing system being in sealing configuration prior to an advancement of the carrier, relaxed upon an advancement of the carrier and returned to its sealing configuration at the latest after release of the powder associated with said area of the carrier.
摘要翻译： 干粉吸入器和干粉吸入器储存盒，其包括容纳预先装载有多个剂量的细分散粉末的细长载体的隔室，其包含生物活性物质，所述隔室被构造成使得所述预加载的剂量被密封在所述隔间内， 载体可以通过设置有防潮密封系统的出口从隔室推进到室，其中防潮密封系统被构造和布置成使得其在载体的前进过程中可松弛，所述密封系统处于密封配置 在载体的推进之后，随着载体的推进而放松，并且在释放与载体的所述区域相关联的粉末之后最后返回到其密封构造。
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