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公开(公告)号：US07459146B2
公开(公告)日：2008-12-02
申请号：US10449443
申请日：2003-05-30
CPC分类号： A61K9/008 , A61K47/02 , B01F17/0078 , B01F17/0085 , B01J13/0095 , Y10S514/937
摘要： The invention relates to stabilized dispersions containing nanoparticles of use for the administration of medicaments. The dispersions comprise excipient nanoparticles, a dispersed phase comprising medicament and a continuous phase comprising propellant.
摘要翻译： 本发明涉及包含用于给药药物的纳米颗粒的稳定分散体。 分散体包括赋形剂纳米颗粒，包含药物的分散相和包含推进剂的连续相。
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2.发明授权Methods of treating mammals with stabilized particle dispersions containing excipient surface-modified nanoparticles 有权用含有赋形剂表面改性纳米粒子的稳定化颗粒分散体处理哺乳动物的方法公开(公告)号：US07476694B2
公开(公告)日：2009-01-13
申请号：US11463621
申请日：2006-08-10
CPC分类号： A61K47/34 , A61K9/008 , A61K47/06 , A61K47/32 , Y10S514/844 , Y10S514/938 , Y10S977/773 , Y10S977/786 , Y10S977/915
摘要： In one aspect, the invention provides a stable dispersion comprising a continuous phase comprising a continuous liquid phase and a plurality of organic nanoparticles; and a dispersed phase comprising particles dispersed in the continuous phase.
摘要翻译： 在一个方面，本发明提供了包含连续相的稳定分散体，所述连续相包含连续液相和多个有机纳米颗粒; 以及包含分散在连续相中的颗粒的分散相。
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3.发明授权Stabilized dispersions comprising excipient surface-modified organic nanoparticles and medicament particles 有权包含赋形剂表面改性的有机纳米颗粒和药物颗粒的稳定分散体公开(公告)号：US07425582B2
公开(公告)日：2008-09-16
申请号：US11463616
申请日：2006-08-10
CPC分类号： A61K47/34 , A61K9/008 , A61K47/06 , A61K47/32 , Y10S514/844 , Y10S514/938 , Y10S977/773 , Y10S977/786 , Y10S977/915
摘要： In one aspect, the invention provides a stable dispersion comprising a continuous phase comprising a continuous liquid phase and a plurality of organic nanoparticles; and a dispersed phase comprising particles dispersed in the continuous phase.
摘要翻译： 在一个方面，本发明提供了包含连续相的稳定分散体，所述连续相包含连续液相和多个有机纳米颗粒; 以及包含分散在连续相中的颗粒的分散相。
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4.发明申请STABILIZED PARTICLE DISPERSIONS CONTAINING SURFACE-MODIFIED INORGANIC NANOPARTICLES 审中-公开含有表面改性无机纳米颗粒的稳定颗粒分散体公开(公告)号：US20080268062A1
公开(公告)日：2008-10-30
申请号：US12167714
申请日：2008-07-03
IPC分类号： A61K9/51
CPC分类号： B01F17/0078 , A61K9/10 , A61K47/02 , A61K47/24
摘要： This invention relates to particle-in-liquid dispersions containing surface-modified inorganic nanoparticles.
摘要翻译： 本发明涉及含有表面改性无机纳米粒子的粒子 - 液体分散体。
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公开(公告)号：US20080063714A1
公开(公告)日：2008-03-13
申请号：US10595051
申请日：2004-07-29
申请人： Hassan Sahouani , Robert A. Scherrer , Kim M. Vogel , Dennis E. Vogel , Stephen W. Stein , Brian J. Gabrio , Stephanie F. Bernatchez , Richard H. Ferber , Wei Zou
发明人： Hassan Sahouani , Robert A. Scherrer , Kim M. Vogel , Dennis E. Vogel , Stephen W. Stein , Brian J. Gabrio , Stephanie F. Bernatchez , Richard H. Ferber , Wei Zou
CPC分类号： A61K9/0019 , A61K47/22
摘要： The invention comprises compositions and methods useful for encapsulation and controlled release of guest molecules, such as drugs. Compositions of the present invention comprise a matrix comprising molecules that are non-covalently crosslinked by multi-valent cations, wherein the molecules that are non-covalently crosslinked are non-polymeric, have more than one carboxy functional group, and have at least partial aromatic or heteroaromatic character The compositions are characterized in that a guest molecule may be encapsulated within the matrix and subsequently released.
摘要翻译： 本发明包括可用于包封和控制释放客体分子（例如药物）的组合物和方法。 本发明的组合物包含基质，其包含由多价阳离子非共价交联的分子，其中非共价交联的分子是非聚合的，具有多于一个羧基官能团，并且具有至少部分芳族 或杂芳族特征该组合物的特征在于可以将客体分子包封在基质内并随后释放。
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公开(公告)号：US06615826B1
公开(公告)日：2003-09-09
申请号：US09510388
申请日：2000-02-22
IPC分类号： A61M1100
CPC分类号： A61M15/0086 , A61M11/001 , A61M15/009 , A61M15/0096
摘要： A pressurized metered dose inhaler having an actuator constructed and arranged so as to inhibit airflow due to patient inhalation in the vicinity of the orifice of the nozzle block when the valve stem is in its dispensing position. This design reduces unwanted oropharyngeal deposition of medicament and increases the relative amount of medicament to the lung.
摘要翻译： 一种具有致动器的加压计量吸入器，其构造和布置成当阀杆处于其分配位置时阻止由于患者在喷嘴座的孔口附近吸入而引起的气流。 该设计减少药物的不希望的口咽沉积，并增加药物对肺的相对量。
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