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公开(公告)号：US20130196414A1
公开(公告)日：2013-08-01
申请号：US13846338
申请日：2013-03-18
Applicant: ALLERGAN, INC.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
IPC: C12N9/52
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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公开(公告)号：US20240018500A1
公开(公告)日：2024-01-18
申请号：US17934914
申请日：2022-09-23
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Femandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C12Y304/24069 , C07K14/33
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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公开(公告)号：US20230279083A1
公开(公告)日：2023-09-07
申请号：US17936691
申请日：2022-09-29
Applicant: Allergan, Inc.
Inventor： Ester Fernandez-Salas , Joanne Wang , Patton E. Garay , Lina Wong , D. Dianne Hodges , Kei Roger Aoki
IPC: C07K16/12 , G01N33/566 , G01N33/50 , G01N33/68 , C12Q1/37 , G01N33/569
CPC classification number: C07K16/1282 , G01N33/566 , G01N33/5014 , G01N33/6854 , C12Q1/37 , G01N33/56911 , C07K2317/77 , G01N2333/33 , C07K2317/56 , G01N2333/705 , C07K2317/34 , C07K2317/92 , G01N2333/952 , C07K2317/565
Abstract: The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
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公开(公告)号：US20230235031A1
公开(公告)日：2023-07-27
申请号：US17889919
申请日：2022-08-17
Applicant: Allergan, Inc.
Inventor： Ester Fernandez-Salas , Joanne Wang , Patton E. Garay , Lina Wong , D. Dianne Hodges , Kei Roger Aoki
IPC: C07K16/12 , G01N33/68 , G01N33/566 , C12Q1/37 , G01N33/50 , G01N33/569
CPC classification number: C07K16/1282 , G01N33/6854 , G01N33/566 , C12Q1/37 , G01N33/5014 , G01N33/56911 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/77 , G01N2333/33 , G01N2333/705 , G01N2333/952
Abstract: The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
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公开(公告)号：US09284545B2
公开(公告)日：2016-03-15
申请号：US14087952
申请日：2013-11-22
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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Patent Agency Ranking
公开(公告)号：US09279116B2
公开(公告)日：2016-03-08
申请号：US14086840
申请日：2013-11-21
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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公开(公告)号：US20140127783A1
公开(公告)日：2014-05-08
申请号：US14086840
申请日：2013-11-21
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
IPC: C12N9/52
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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公开(公告)号：US20130288334A1
公开(公告)日：2013-10-31
申请号：US13846364
申请日：2013-03-18
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
IPC: C12N9/52
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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公开(公告)号：US20130273633A1
公开(公告)日：2013-10-17
申请号：US13846307
申请日：2013-03-18
Applicant: ALLERGAN, INC.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
IPC: C12N9/52
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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30.发明申请METHODS OF TREATING CANCER USING OPIOD RETARGETED ENDOPEPIDASES 审中-公开使用OPIOD RETARGETED ENDOPEPIDAS治疗癌症的方法公开(公告)号：US20130230502A1
公开(公告)日：2013-09-05
申请号：US13682398
申请日：2012-11-20
Applicant: ALLERGAN, INC.
Inventor： Birgitte P.S. Jacky , Patton E. Garay , Yanira Molina , Dean G. Stathakis , Joseph Francis , Kei Roger Aoki , Ester Fernandez-Salas
IPC: A61K38/43
CPC classification number: A61K38/43 , A61K38/4893 , C07K14/33 , C07K2319/00
Abstract: The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.
Abstract translation: 本说明书公开了TVEMP，包含这样的TVEMP的组合物和使用这种TVEMP组合物治疗哺乳动物癌症的方法。
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