公开(公告)号：US20210094944A1

公开(公告)日：2021-04-01

申请号：US17030504

申请日：2020-09-24

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Masahiro ITO ,  Hideyuki SUGIYAMA ,  Takeshi YAMAMOTO ,  Keiko KAKEGAWA ,  Jinxing LI ,  Junsi WANG ,  Takahito KASAHARA ,  Masato YOSHIKAWA

IPC: C07D413/14 ,  C07D413/10 ,  A61P25/28

Abstract: The present invention provides a heterocyclic compound having a HDAC6 inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

公开(公告)号：US20200157117A1

公开(公告)日：2020-05-21

申请号：US16779797

申请日：2020-02-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Haruhi ANDO ,  William John FARNABY

IPC: C07D498/08 ,  C07D405/14 ,  C07D413/14 ,  C07D413/10 ,  C07D401/14 ,  C07D401/10 ,  C07D417/14 ,  C07D405/10

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20170145031A1

公开(公告)日：2017-05-25

申请号：US15424075

申请日：2017-02-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Haruhi ANDO ,  William John FARNABY ,  Toshiya NISHI

IPC: C07D498/08 ,  C07D413/14 ,  C07D405/10 ,  C07D405/14 ,  C07D417/14 ,  C07D401/10 ,  C07D401/14

CPC classification number: C07D498/08 ,  C07D401/10 ,  C07D401/14 ,  C07D405/10 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20160052897A1

公开(公告)日：2016-02-25

申请号：US14781665

申请日：2014-04-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Izumi NOMURA ,  Yoshiteru ITO ,  Eiji KIMURA ,  Haruhi ANDO ,  Tomoaki HASUI ,  Toshiya NISHI

IPC: C07D263/32 ,  C07D491/08 ,  C07D413/04 ,  C07D413/14 ,  C07D413/12 ,  C07D413/10

CPC classification number: C07D263/32 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D491/08

Abstract: The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.

Abstract translation: 本发明涉及式（I）表示的化合物，其可用作预防或治疗癫痫，神经变性疾病等的药剂。 在式（I）中，每个符号如说明书中所定义。

公开(公告)号：US20130090341A1

公开(公告)日：2013-04-11

申请号：US13633995

申请日：2012-10-03

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Haruhi KAMISAKI ,  William John FARNABY

IPC: C07D401/10 ,  C07D413/14 ,  C07D401/14 ,  A61K31/506 ,  A61P25/16 ,  A61K31/501 ,  C07D413/10 ,  A61K31/454 ,  A61P25/28 ,  A61K31/4545 ,  C07D417/14

CPC classification number: C07D498/08 ,  C07D401/10 ,  C07D401/14 ,  C07D405/10 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供可用作预防或治疗神经变性疾病等的药剂或其盐。 本发明涉及由下式表示的化合物，其中每个符号如说明书中所定义，或其盐。