公开(公告)号：US20160024049A1

公开(公告)日：2016-01-28

申请号：US14781963

申请日：2014-04-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Haruhi ANDO ,  William John FARNABY ,  Shuhei IKEDA ,  Yuichi KAJITA ,  Toshiya NISHI

IPC: C07D401/10 ,  C07D213/56 ,  C07D401/14 ,  C07D403/12 ,  C07D239/26 ,  C07D213/42 ,  C07D405/14 ,  C07D417/14 ,  C07D401/12 ,  C07D413/14

CPC classification number: C07D401/10 ,  C07D213/34 ,  C07D213/42 ,  C07D213/56 ,  C07D239/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.

公开(公告)号：US20170197983A1

公开(公告)日：2017-07-13

申请号：US15467548

申请日：2017-03-23

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Yuichi KAJITA ,  Masato YOSHIKAWA ,  Shuhei IKEDA ,  Eiji KIMURA ,  Tomoaki HASUI ,  Toshiya NISHI ,  Hiromi FUKUDA

IPC: C07D498/08 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D471/10 ,  C07D405/14 ,  C07D213/74 ,  C07D239/42 ,  C07D401/04 ,  C07D401/14 ,  C07D487/18

CPC classification number: C07D498/08 ,  A61K9/2018 ,  A61K9/4858 ,  C07D213/12 ,  C07D213/72 ,  C07D213/74 ,  C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D451/02 ,  C07D451/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/08 ,  C07D487/10 ,  C07D487/18 ,  C07D491/08 ,  C07D491/18 ,  C12N9/99

Abstract: An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20170145031A1

公开(公告)日：2017-05-25

申请号：US15424075

申请日：2017-02-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Haruhi ANDO ,  William John FARNABY ,  Toshiya NISHI

IPC: C07D498/08 ,  C07D413/14 ,  C07D405/10 ,  C07D405/14 ,  C07D417/14 ,  C07D401/10 ,  C07D401/14

CPC classification number: C07D498/08 ,  C07D401/10 ,  C07D401/14 ,  C07D405/10 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20160052897A1

公开(公告)日：2016-02-25

申请号：US14781665

申请日：2014-04-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Izumi NOMURA ,  Yoshiteru ITO ,  Eiji KIMURA ,  Haruhi ANDO ,  Tomoaki HASUI ,  Toshiya NISHI

IPC: C07D263/32 ,  C07D491/08 ,  C07D413/04 ,  C07D413/14 ,  C07D413/12 ,  C07D413/10

CPC classification number: C07D263/32 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D491/08

Abstract: The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.

Abstract translation: 本发明涉及式（I）表示的化合物，其可用作预防或治疗癫痫，神经变性疾病等的药剂。 在式（I）中，每个符号如说明书中所定义。

公开(公告)号：US20210346366A1

公开(公告)日：2021-11-11

申请号：US17277917

申请日：2019-09-19

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Mahnaz ASGHARNEJAD ,  Dimitrios ARKILO ,  Toshiya NISHI

IPC: A61K31/4545 ,  A61P25/06

Abstract: The present disclosure relates to methods of treating pain by administration of (4-benzyl-4-hydroxypiperidin-1-yl) (2,4′-bipyridin-3-yl)methanone or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20190071455A1

公开(公告)日：2019-03-07

申请号：US16194540

申请日：2018-11-19

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Haruhi ANDO ,  William John FARNABY ,  Toshiya NISHI

IPC: C07D498/08 ,  C07D405/10 ,  C07D405/14 ,  C07D413/14 ,  C07D401/10 ,  C07D413/10 ,  C07D417/14 ,  C07D401/14

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20230087903A1

公开(公告)日：2023-03-23

申请号：US17893905

申请日：2022-08-23

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Toshiya NISHI ,  Shinichi KONDO

IPC: A61K31/4545 ,  A61P25/08

Abstract: Aspects of the present invention relate to a method of treating an epileptic encephalopathy in a mammal in need thereof, comprising administering a composition comprising an effective amount of (4-benzyl-4-hydroxypiperidin-1-yl) (2,4′-bipyridin-3-yl)methanone or a pharmaceutically acceptable salt thereof to the mammal.

公开(公告)号：US20200306238A1

公开(公告)日：2020-10-01

申请号：US16642153

申请日：2018-08-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Toshiya NISHI ,  Shinichi KONDO

IPC: A61K31/4545 ,  A61P25/08

Abstract: Aspects of the present invention relate to a method of treating an epileptic encephalopathy in a mammal in need thereof, comprising administering a composition comprising an effective amount of (4-benzyl-4-hydroxypiperidin-1-yl) (2,4′-bipyridin-3-yl)methanone or a pharmaceutically acceptable salt thereof to the mammal.

公开(公告)号：US20160326136A1

公开(公告)日：2016-11-10

申请号：US15221761

申请日：2016-07-28

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Haruhi ANDO ,  William John FARNABY ,  Toshiya NISHI

IPC: C07D401/10 ,  C07D405/14 ,  C07D498/08 ,  C07D413/10 ,  C07D417/14 ,  C07D413/14 ,  C07D401/14

CPC classification number: C07D498/08 ,  C07D401/10 ,  C07D401/14 ,  C07D405/10 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 其中每个符号如说明书中所定义，或其盐。

公开(公告)号：US20150315209A1

公开(公告)日：2015-11-05

申请号：US14650429

申请日：2013-12-10

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Yuichi KAJITA ,  Masato YOSHIKAWA ,  Shuhei IKEDA ,  Eiji KIMURA ,  Tomoaki HASUI ,  Toshiya NISHI ,  Hiromi FUKUDA

IPC: C07D498/08 ,  C07D413/14 ,  C07D417/14 ,  C07D403/04 ,  C07D405/14 ,  C07D471/10 ,  C07D401/04 ,  C07D401/14 ,  C07D471/08

CPC classification number: C07D498/08 ,  A61K9/2018 ,  A61K9/4858 ,  C07D213/12 ,  C07D213/72 ,  C07D213/74 ,  C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D451/02 ,  C07D451/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/08 ,  C07D487/10 ,  C07D487/18 ,  C07D491/08 ,  C07D491/18 ,  C12N9/99

Abstract: An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 本发明的目的是提供具有优异CH24H抑制作用的化合物，其可用作预防或治疗癫痫，神经变性疾病等的药剂。 本发明涉及由下式表示的化合物：其中每个符号如说明书中所定义，或其盐。