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公开(公告)号：US20230235055A1
公开(公告)日：2023-07-27
申请号：US18007185
申请日：2021-07-26
Inventor： Zhiqiang AN , Chengcheng ZHANG , Ningyan ZHANG , Yuanzhi CHEN , Heyu CHEN
IPC: C07K16/28 , A61K45/06 , G01N33/574 , A61K39/395 , A61P35/00
CPC classification number: C07K16/2803 , A61K45/06 , G01N33/57484 , A61K39/3955 , A61P35/00 , C07K2317/21 , C07K2317/24 , C07K2317/73 , A61K2039/505
Abstract: Provided herein are antibodies binding to LILRB1 and the uses of the antibodies in detecting and treating cancer and autoimmune diseases.
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Patent Agency Ranking
公开(公告)号：US20220056124A1
公开(公告)日：2022-02-24
申请号：US17273538
申请日：2019-09-05
Inventor： Ningyan ZHANG , Dawei BU , Zhiqiang AN , Hui DENG , Philipp E. SCHERER
Abstract: Aspects of the present invention relate to methods and reagents for increasing chemosensitivity to platinum-based chemotherapy. In one aspect, a method of increasing chemosensitivity to platinum-based chemotherapy is provided, comprising administering to a patient in need thereof an effective amount of an endotrophin-neutralizing agent. The agent can be a monoclonal antibody, or fragment thereof, capable of binding to the C5 domain of the alphas chain of collagen VI. In some embodiments, the method can further include administering an effective amount of thiazolidinedione to said patient.
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公开(公告)号：US20210371508A1
公开(公告)日：2021-12-02
申请号：US17332790
申请日：2021-05-27
Inventor： Ningyan ZHANG , Zhiqiang AN , Zhiqiang KU , Yihong WAN , Jing KRZESZINSKI
IPC: C07K16/18 , A61K45/06 , G01N33/574 , A61K47/68
Abstract: Provided herein are methods for treating cancer, such as breast cancer, by administering an inhibitor of NMES1. Further provided herein are NMES1 monoclonal antibodies which may be used to detect or treat cancer.
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公开(公告)号：US20200055954A1
公开(公告)日：2020-02-20
申请号：US16441350
申请日：2019-06-14
Inventor： Ningyan ZHANG , Zhiqiang AN
IPC: C07K16/32 , G01N33/574 , A61N5/10 , A61K45/06 , A61K39/395 , A61F7/10
Abstract: Isolated or recombinant anti-HER3 monoclonal antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer.
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公开(公告)号：US20180086829A1
公开(公告)日：2018-03-29
申请号：US15696972
申请日：2017-09-06
Inventor： Chengcheng ZHANG , Mi DENG , Wei XIONG , Zhiqiang AN , Ningyan ZHANG , Xun GUI , Junke ZHENG
IPC: C07K16/28 , C07K16/30 , A61P35/02 , A61K45/06 , A61K39/395 , G01N33/574
CPC classification number: C07K16/2803 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61P35/02 , C07K16/3061 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C12N15/1138 , C12N2310/14 , C12N2310/531 , G01N33/57426 , G01N33/57492 , G01N2333/70503
Abstract: The present disclosure is directed to antibodies binding to LILRBs and methods of detecting and treating cancer therewith.
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26.发明申请公开(公告)号：US20160032011A1
公开(公告)日：2016-02-04
申请号：US14774808
申请日：2014-03-13
Inventor： Ningyan ZHANG , Zhiqiang AN
IPC: C07K16/32 , A61F7/10 , G01N33/574 , A61N5/10 , A61K39/395 , A61K45/06
CPC classification number: C07K16/32 , A61F7/10 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07K2317/14 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57484 , G01N33/57492
Abstract: Isolated or recombinant anti-HER3 monoclonal antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer.
Abstract translation: 提供了分离或重组的抗HER3单克隆抗体。 在一些情况下，实施方案的抗体可用于人类疾病如癌症的检测，诊断和/或治疗治疗。
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