公开(公告)号：US20230364084A1

公开(公告)日：2023-11-16

申请号：US18033747

申请日：2021-10-28

Applicant: The Regents of the University of Michigan

Inventor： Yuanyuan Qiao ,  Arul Chinnaiyan

IPC: A61K31/506 ,  A61K39/395 ,  A61P35/00

CPC classification number: A61K31/506 ,  A61K39/3955 ,  A61P35/00

Abstract: Provided herein are compositions and methods for preventing, attenuating or treating disorders characterized with characterized with PIKfyve-expressing cells. In particular, provided herein are methods for preventing, attenuating or treating disorders characterized with PIKfyve-expressing cells through use of compositions comprising a therapeutic agent capable of inhibiting PIKfyve activity.

公开(公告)号：US11746151B2

公开(公告)日：2023-09-05

申请号：US17046998

申请日：2019-04-12

Applicant: The Regents of the University of Michigan

Inventor： Arul Chinnaiyan ,  Dan Robinson ,  Yi-Mi Wu ,  Marcin Cieslik

IPC: C07K16/28 ,  A61P35/00 ,  C12Q1/6886

CPC classification number: C07K16/2818 ,  A61P35/00 ,  C07K16/28 ,  C12Q1/6886 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2319/30 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of targeted therapy to treat cancer (e.g., prostate cancer) in subjects with CDK12 mutations.

公开(公告)号：US10774122B2

公开(公告)日：2020-09-15

申请号：US15924377

申请日：2018-03-19

Applicant: The Regents of the University of Michigan

Inventor： Arul Chinnaiyan ,  Xiaoju Wang

IPC: C07K14/47 ,  A61K9/127 ,  A61K47/60 ,  A61K9/107 ,  A61K47/54 ,  A61K47/64 ,  C07K14/82 ,  A61K38/00

Abstract: The present disclosure relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present disclosure relates to recurrent gene fusions as clinical targets for cancer.

公开(公告)号：US10190173B2

公开(公告)日：2019-01-29

申请号：US15149780

申请日：2016-05-09

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： Scott Tomlins ,  Daniel Rhodes ,  Arul Chinnaiyan ,  Rohit Mehra ,  Mark A. Rubin ,  Xiao-Wei Sun ,  Sven Perner ,  Charles Lee ,  Francesca Demichelis

IPC: C12Q1/68 ,  C12Q1/6886 ,  C12N15/113 ,  G01N33/574 ,  A01K67/027 ,  C07K14/82 ,  C12N9/64

Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.

公开(公告)号：US20180273595A1

公开(公告)日：2018-09-27

申请号：US15924377

申请日：2018-03-19

Applicant: The Regents of the University of Michigan

Inventor： Arul Chinnaiyan ,  Xiaoju Wang

IPC: C07K14/47 ,  A61K9/127 ,  A61K9/107 ,  A61K47/60

Abstract: The present disclosure relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present disclosure relates to recurrent gene fusions as clinical targets for cancer.

公开(公告)号：US09580430B2

公开(公告)日：2017-02-28

申请号：US14633360

申请日：2015-02-27

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Yujun Zhao ,  Bing Zhou ,  Angelo Aguilar ,  Liu Liu ,  Longchuan Bai ,  Donna McEachern ,  Duxin Sun ,  Bo Wen ,  Ruijuan Luo ,  Ting Zhao ,  Arul Chinnaiyan ,  Irfan A. Asangani ,  Jeanne Stuckey ,  Jennifer Lynn Meagher ,  Xu Ran ,  Yang Hu

IPC: A01N43/54 ,  A61K31/505 ,  C07D491/00 ,  C07D487/04 ,  A61K31/519 ,  C07D487/14 ,  C07D519/00

CPC classification number: C07D519/00 ,  A61K31/437 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  C07D487/04 ,  C07D487/14

Abstract: The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, A, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains. Compounds of the present disclosure are especially useful for treating cancer.

Abstract translation: 本公开提供取代的9H-嘧啶并[4,5-b]吲哚和5H-吡啶并[4,3-b]吲哚和由式I表示的相关类似物及其药学上可接受的盐，水合物和溶剂合物，其中R1a A，B1，B2，G，X1，Y1，Y2和Y3如说明书中所述。 本公开还涉及式I化合物用于治疗对抑制BET溴结构域有反应的病症或病症。 本公开的化合物特别可用于治疗癌症。

公开(公告)号：US20140256706A1

公开(公告)日：2014-09-11

申请号：US14204076

申请日：2014-03-11

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Xu Ran ,  Yujun Zhao ,  Chao-Yie Yang ,  Liu Liu ,  Longchuan Bai ,  Donna McEachern ,  Jeanne Stuckey ,  Jennifer Lynn Meagher ,  Duxin Sun ,  Xiaoqin Li ,  Bing Zhou ,  Hacer Karatas ,  Ruijuan Luo ,  Arul Chinnaiyan ,  Irfan A. Asangani

IPC: A61K31/5377 ,  A61K31/437 ,  A61K45/06 ,  C07D471/04 ,  C07D491/056 ,  A61K31/519 ,  C07D487/04

CPC classification number: A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/056

Abstract: Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.

Abstract translation: 公开了BET溴结构域的抑制剂和含有它们的组合物。 还公开了使用BET溴域结构域抑制剂治疗其中抑制BET溴结构域提供益处的疾病和病症的方法，如癌症。

公开(公告)号：US12270080B2

公开(公告)日：2025-04-08

申请号：US16523008

申请日：2019-07-26

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Arul Chinnaiyan ,  John Prensner ,  Matthew Iyer

IPC: C12Q1/68 ,  A61K31/4184 ,  C12Q1/6886

Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ncRNAs as diagnostic markers and clinical targets for prostate, lung, breast and pancreatic cancer.

公开(公告)号：US11013754B2

公开(公告)日：2021-05-25

申请号：US16378825

申请日：2019-04-09

Applicant: The Regents of the University of Michigan

Inventor： Arul Chinnaiyan ,  Rohit Malik ,  Yajia Zhang ,  Marcin Cieslik ,  Sethuramasundaram Pitchiaya

IPC: A61K31/7105 ,  C12N15/113 ,  G01N33/574

Abstract: Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of inhibitors of ARlnc1 for treating cancer.

公开(公告)号：US10889864B2

公开(公告)日：2021-01-12

申请号：US14962961

申请日：2015-12-08

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Arul Chinnaiyan ,  Felix Y. Feng ,  John Prensner ,  Matthew Iyer ,  Yashar Niknafs

IPC: C12Q1/6886

Abstract: Provided herein are compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, provided herein are non-coding RNAs as diagnostic markers and clinical targets for cancer.