公开(公告)号：US20190307787A1

公开(公告)日：2019-10-10

申请号：US16378825

申请日：2019-04-09

Applicant: The Regents of the University of Michigan

Inventor： Arul Chinnaiyan ,  Rohit Malik ,  Yajia Zhang ,  Marcin Cieslik ,  Sethuramasundaram Pitchiaya

IPC: A61K31/7105 ,  C12N15/113 ,  G01N33/574

Abstract: Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of inhibitors of ARlnc1 for treating cancer.

公开(公告)号：US20170210761A1

公开(公告)日：2017-07-27

申请号：US15443336

申请日：2017-02-27

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Yujun Zhao ,  Bing Zhou ,  Angelo Aguilar ,  Liu Liu ,  Longchuan Bai ,  Donna McEachern ,  Duxin Sun ,  Bo Wen ,  Ruijuan Luo ,  Ting Zhao ,  Arul Chinnaiyan ,  Irfan A. Asangani ,  Jeanne Stuckey ,  Jennifer Lynn Meagher ,  Xu Ran ,  Yang Hu

IPC: C07D519/00 ,  A61K31/519 ,  C07D487/14 ,  A61K31/538 ,  A61K31/437 ,  C07D487/04 ,  A61K31/5377

CPC classification number: C07D519/00 ,  A61K31/437 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  C07D487/04 ,  C07D487/14

Abstract: The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, A, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains. Compounds of the present disclosure are especially useful for treating cancer.

公开(公告)号：US20160319369A1

公开(公告)日：2016-11-03

申请号：US15149780

申请日：2016-05-09

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： Scott Tomlins ,  Daniel Rhodes ,  Arul Chinnaiyan ,  Rohit Mehra ,  Mark A. Rubin ,  Xiao-Wei Sun ,  Sven Perner ,  Charles Lee ,  Francesca Demichelis

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  A01K67/0275 ,  A01K2217/072 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0331 ,  C07K14/82 ,  C07K2319/00 ,  C12N9/6424 ,  C12N9/6445 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57434 ,  Y10S435/81

Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.

公开(公告)号：US20230016456A1

公开(公告)日：2023-01-19

申请号：US17813193

申请日：2022-07-18

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Arul Chinnaiyan ,  John Prensner ,  Matthew Iyer

IPC: C12Q1/6886

Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ncRNAs as diagnostic markers and clinical targets for prostate, lung, breast and pancreatic cancer.

公开(公告)号：US11015224B2

公开(公告)日：2021-05-25

申请号：US15370750

申请日：2016-12-06

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Arul Chinnaiyan ,  Nallasivam Palanisamy ,  Shanker Kalyana-Sundaram

IPC: C12Q1/68 ,  G01N33/574 ,  C12N9/12 ,  C12Q1/6886

Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to RAF gene fusions as diagnostic markers and clinical targets for cancer.

公开(公告)号：US10815484B2

公开(公告)日：2020-10-27

申请号：US16195185

申请日：2018-11-19

Applicant: The Regents of the University of Michigan

Inventor： Arul Chinnaiyan ,  Yasuyuki Hosono

IPC: C12N15/113 ,  A61P35/00

Abstract: Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of inhibitors of THOR for treating cancer.

公开(公告)号：US20200224276A1

公开(公告)日：2020-07-16

申请号：US16523008

申请日：2019-07-26

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Arul Chinnaiyan ,  John Prensner ,  Matthew Iyer

IPC: C12Q1/6886 ,  A61K31/4184

Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ncRNAs as diagnostic markers and clinical targets for prostate, lung, breast and pancreatic cancer.

公开(公告)号：US10391175B2

公开(公告)日：2019-08-27

申请号：US15619671

申请日：2017-06-12

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Xu Ran ,  Yujun Zhao ,  Chao-Yie Yang ,  Liu Liu ,  Longchuan Bai ,  Donna McEachern ,  Jeanne Stuckey ,  Jennifer Lynn Meagher ,  Duxin Sun ,  Xiaoqin Li ,  Bing Zhou ,  Hacer Karatas ,  Ruijuan Luo ,  Arul Chinnaiyan ,  Irfan A. Asangani

IPC: A61K31/519 ,  C07D471/04 ,  A61K45/06 ,  C07D487/04 ,  C07D491/056

Abstract: Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.

公开(公告)号：US09783853B2

公开(公告)日：2017-10-10

申请号：US14329639

申请日：2014-07-11

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Arul Chinnaiyan ,  Yi-Mi Wu ,  Dan Robinson

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q2600/156 ,  G01N33/57492 ,  G01N2333/71

Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to gene fusions as diagnostic markers and clinical targets for cancer.

公开(公告)号：US20170081731A1

公开(公告)日：2017-03-23

申请号：US15370750

申请日：2016-12-06

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Arul Chinnaiyan ,  Nallasivam Palanisamy ,  Shanker Kalyana-Sundaram

IPC: C12Q1/68 ,  C12N9/12 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12N9/12 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y207/11001 ,  G01N33/5748 ,  G01N2333/912 ,  G01N2333/91205

Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to RAF gene fusions as diagnostic markers and clinical targets for cancer.