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公开(公告)号:US07294625B2
公开(公告)日:2007-11-13
申请号:US10528994
申请日:2003-09-25
申请人: Masahiko Hagihara , Nobuhiko Shibakawa , Masamichi Nishihara , Toshiyuki Shirai , Motohisa Shimizu , Tohru Hasegawa , Yasunori Tokunaga , Naoto Suzuki , Yukinori Wada
发明人: Masahiko Hagihara , Nobuhiko Shibakawa , Masamichi Nishihara , Toshiyuki Shirai , Motohisa Shimizu , Tohru Hasegawa , Yasunori Tokunaga , Naoto Suzuki , Yukinori Wada
IPC分类号: C07D487/04 , C07D401/14 , C07D403/14 , A61K31/501 , A61K31/5025
CPC分类号: C07D401/14 , A61K31/501 , A61K31/5025 , A61K31/506 , C07D403/14 , C07D487/04
摘要: The present invention relates to pyrazole compounds represented by the formula (I): wherein R1 represents phenyl which may be substituted, R2 represents H, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl or substituted amino, Q represents CH or N, R3 represents H, alkyl or amino, R4 represents the formula (II) to (V): wherein R7 represents H or alkyl, R8 represents H, alkyl or substituted amino, R9 represents H or alkyl, R12 represents H, alkyl, halogeno alkyl or substituted amino, or pharmaceutically acceptable salts thereof, and a medical composition containing the same as effective ingredient.
摘要翻译: 本发明涉及由式(I)表示的吡唑化合物:其中R 1表示可被取代的苯基,R 2表示H,卤素,烷基,烷氧基, 烷硫基,烷基亚磺酰基,烷基磺酰基或取代的氨基,Q表示CH或N,R 3表示H,烷基或氨基,R 4表示式(II)至(V) :其中R 7表示H或烷基,R 8表示H,烷基或取代的氨基,R 9表示H或烷基,R SUP > 12表示H,烷基,卤代烷基或取代的氨基或其药学上可接受的盐,以及含有与有效成分相同的药物组合物。