公开(公告)号：US20220054602A1

公开(公告)日：2022-02-24

申请号：US17465287

申请日：2021-09-02

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Michael Heartlein ,  Frank DeRosa

IPC: A61K38/47 ,  A61K48/00 ,  C07K14/505 ,  C07K14/61 ,  C12N15/67 ,  C12N9/10 ,  C12N9/40 ,  A61K38/27 ,  A61K38/45 ,  A61K38/18

Abstract: Compositions for modulating the expression of a protein in a target cell comprising at least one RNA molecule which comprises at least one modification 5 conferring stability to the RNA, as well as related methods, are disclosed.

公开(公告)号：US11052159B2

公开(公告)日：2021-07-06

申请号：US17099462

申请日：2020-11-16

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K48/00 ,  A61K31/713 ,  A61K38/18 ,  A61K38/47 ,  A61K38/48 ,  A61K38/57 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  C07K14/505 ,  C07K14/81 ,  C12N15/52 ,  C12N15/85 ,  C12N9/40 ,  C12N9/64

Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

公开(公告)号：US10899830B2

公开(公告)日：2021-01-26

申请号：US16752327

申请日：2020-01-24

Applicant: Translate Bio, Inc.

Inventor： Michael Heartlein ,  Frank DeRosa ,  Anusha Dias ,  Braydon Charles Guild

IPC: C07K16/24 ,  C07K16/22 ,  C12N15/88 ,  A61K9/00 ,  A61K9/127 ,  A61K47/69

Abstract: The present invention provides, among other things, methods and compositions for delivering an antibody in vivo by administering to a subject in need thereof one or more mRNAs encoding a heavy chain and a light chain of an antibody, and wherein the antibody is expressed systemically in the subject. In some embodiments, the one or more mRNAs comprise a first mRNA encoding the heavy chain and a second mRNA encoding the light chain of the antibody.

公开(公告)号：US10888626B2

公开(公告)日：2021-01-12

申请号：US16931231

申请日：2020-07-16

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K48/00 ,  A61K9/00 ,  A61K38/45 ,  C12N9/64 ,  A61K31/713 ,  A61K38/57 ,  A61K38/47 ,  A61K38/18 ,  C07K14/81 ,  C12N15/52 ,  C12N15/85 ,  A61K9/51 ,  C12N9/40 ,  C07K14/505 ,  A61K9/127 ,  A61K38/48

Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

公开(公告)号：US10766852B2

公开(公告)日：2020-09-08

申请号：US16100853

申请日：2018-08-10

Applicant: Translate Bio, Inc.

Inventor： Frank DeRosa ,  Braydon Charles Guild ,  Michael Heartlein

IPC: C07C211/21 ,  A61K9/127 ,  C12N15/85 ,  A61K9/50 ,  A61K38/18 ,  A61K38/47

Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.

公开(公告)号：US20200157205A1

公开(公告)日：2020-05-21

申请号：US16752327

申请日：2020-01-24

Applicant: Translate Bio, Inc.

Inventor： Michael Heartlein ,  Frank DeRosa ,  Anusha Dias ,  Braydon Charles Guild

IPC: C07K16/24 ,  A61K9/127 ,  A61K47/69 ,  A61K9/00 ,  C12N15/88 ,  C07K16/22

Abstract: The present invention provides, among other things, methods and compositions for delivering an antibody in vivo by administering to a subject in need thereof one or more mRNAs encoding a heavy chain and a light chain of an antibody, and wherein the antibody is expressed systemically in the subject. In some embodiments, the one or more mRNAs comprise a first mRNA encoding the heavy chain and a second mRNA encoding the light chain of the antibody.

公开(公告)号：US10507183B2

公开(公告)日：2019-12-17

申请号：US15887693

申请日：2018-02-02

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Michael Heartlein ,  Frank DeRosa ,  Jerry Chi Zhang

IPC: A61K9/14 ,  A61K9/19 ,  C07D233/64 ,  A61K9/127 ,  C07C323/25 ,  C07C323/44 ,  C12N15/88 ,  A61K38/45 ,  A61K38/46 ,  A61K38/47 ,  A61K38/50 ,  A61K31/7088 ,  C07C323/27 ,  C07J41/00 ,  C07J43/00 ,  A61K9/51

Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.

公开(公告)号：US20190192690A1

公开(公告)日：2019-06-27

申请号：US16286423

申请日：2019-02-26

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K48/00 ,  C07J43/00 ,  C12N15/67 ,  A61K9/127 ,  A61K9/00 ,  A61K31/7105

CPC classification number: A61K48/0033 ,  A61K9/0019 ,  A61K9/1271 ,  A61K9/1272 ,  A61K31/7105 ,  A61K48/0008 ,  A61K48/005 ,  C07J43/003 ,  C12N15/67

Abstract: Disclosed herein are compositions and methods of modulating the expression of gene or the production of a protein by transfecting target cells with nucleic acids. The compositions disclosed herein demonstrate a high transfection efficacy and are capable of ameliorating diseases associated with protein or enzyme deficiencies.

公开(公告)号：US20190185410A1

公开(公告)日：2019-06-20

申请号：US16100853

申请日：2018-08-10

Applicant: Translate Bio, Inc.

Inventor： Frank DeRosa ,  Braydon Charles Guild ,  Michael Heartlein

IPC: C07C211/21 ,  C12N15/85 ,  A61K9/127 ,  A61K9/50 ,  A61K38/47 ,  A61K38/18

Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.

公开(公告)号：US20190071495A1

公开(公告)日：2019-03-07

申请号：US16129412

申请日：2018-09-12

Applicant: Translate Bio, Inc.

Inventor： Michael Heartlein ,  Frank DeRosa ,  Anusha Dias ,  Braydon Charles Guild

IPC: C07K16/24 ,  A61K47/69 ,  A61K9/127 ,  C07K16/22 ,  A61K9/00 ,  C12N15/88

Abstract: The present invention provides, among other things, methods and compositions for delivering an antibody in vivo by administering to a subject in need thereof one or more mRNAs encoding a heavy chain and a light chain of an antibody, and wherein the antibody is expressed systemically in the subject. In some embodiments, the one or more mRNAs comprise a first mRNA encoding the heavy chain and a second mRNA encoding the light chain of the antibody.