公开(公告)号：US20220152083A1

公开(公告)日：2022-05-19

申请号：US17489983

申请日：2021-09-30

Applicant: University of Massachusetts

Inventor： Peter L. Jones ,  Michael R. Green

IPC: A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  C12N15/113 ,  C12N15/90

Abstract: The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy).

公开(公告)号：US11268150B2

公开(公告)日：2022-03-08

申请号：US16897549

申请日：2020-06-10

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Sanchita Bhatnagar

IPC: C12Q1/6883 ,  G01N33/50

Abstract: In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases.

公开(公告)号：US11160823B2

公开(公告)日：2021-11-02

申请号：US16347688

申请日：2017-11-07

Applicant: University of Massachusetts

Inventor： Peter L. Jones ,  Michael R. Green

IPC: A61K31/713 ,  C12N15/113 ,  A61K31/7105 ,  A61K45/06 ,  C12N15/90

Abstract: The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy).

公开(公告)号：US20210292766A1

公开(公告)日：2021-09-23

申请号：US17265466

申请日：2019-08-29

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Minggang Fang

IPC: C12N15/113 ,  A61K31/4409 ,  A61K31/505 ,  A61K31/472 ,  A61K31/551

Abstract: Methods that include inhibition of ROCK1/2 and other protein kinases to treat Friedreich Ataxia.

公开(公告)号：US20200377952A1

公开(公告)日：2020-12-03

申请号：US16897549

申请日：2020-06-10

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Sanchita Bhatnagar

IPC: C12Q1/6883 ,  G01N33/50

Abstract: In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases.

公开(公告)号：US10428387B2

公开(公告)日：2019-10-01

申请号：US15308673

申请日：2015-05-14

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Leyuan Ma

IPC: A61K31/506 ,  A61K31/519 ,  C12Q1/6886 ,  G01N33/574

Abstract: Methods for treating chronic myeloid leukemia (CML), e.g., BCR-ABL inhibitor imatinib mesylate (IM)-resistant CML, using combination treatments, e.g., combined treatment with a BCR-ABL inhibitor, e.g., IM, and a MEK inhibitor, e.g., trametinib.

公开(公告)号：US20180256682A1

公开(公告)日：2018-09-13

申请号：US15985992

申请日：2018-05-22

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Guangping Gao ,  Manas Kumar Santra ,  Sanchita Bhatnagar

IPC: A61K38/17 ,  C12N9/08 ,  A61K48/00 ,  A61K35/12 ,  A61K38/16

CPC classification number: A61K38/1709 ,  A61K35/12 ,  A61K38/16 ,  A61K48/00 ,  A61K48/005 ,  C12N9/0065

Abstract: Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an SRPX.