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公开(公告)号：US11478529B2
公开(公告)日：2022-10-25
申请号：US16815356
申请日：2020-03-11
摘要： Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an SRPX.
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公开(公告)号：US20220186227A1
公开(公告)日：2022-06-16
申请号：US17439439
申请日：2020-03-28
发明人： Michael R. Green , Dong-Hwan Kim
IPC分类号： C12N15/113 , C07K14/72 , C12N15/11
摘要： Compositions and methods for treating cancers containing an oncogenic KRAS mutant.
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公开(公告)号：US20160206693A1
公开(公告)日：2016-07-21
申请号：US15074714
申请日：2016-03-18
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K35/12 , A61K38/16 , A61K48/00 , A61K48/005 , C12N9/0065
摘要： Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an SRPX.
摘要翻译： 治疗受试者的肿瘤的方法包括鉴定具有肿瘤风险或怀疑具有肿瘤的受试者，并向受试者施用有效量的SRPX。
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公开(公告)号：US11680275B2
公开(公告)日：2023-06-20
申请号：US16619733
申请日：2018-06-06
CPC分类号： C12N15/86 , C07K14/4702 , C07K2319/41 , C12N2310/141 , C12N2330/10 , C12N2750/14143
摘要： In some aspects, the disclosure relates to compositions and methods of engineering a transgene. In some embodiments, the disclosure provides self-regulating recombinant nucleic acids, viral vectors and pharmaceutical compositions comprising a MeCP2 transgene. In some embodiments, compositions and methods described by the disclosure are useful for treating diseases and disorders associated with a loss of function mutation, for example Rett syndrome.
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公开(公告)号：US20220226364A1
公开(公告)日：2022-07-21
申请号：US17714349
申请日：2022-04-06
发明人： Peter L. Jones , Michael R. Green
IPC分类号： A61K31/7105 , A61K45/06 , C12N15/113 , C12N15/90 , A61K31/713
摘要： The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy).
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公开(公告)号：US10718022B2
公开(公告)日：2020-07-21
申请号：US15566533
申请日：2016-04-15
IPC分类号： C12Q1/6883 , G01N33/50
摘要： In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases.
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公开(公告)号：US10130679B2
公开(公告)日：2018-11-20
申请号：US15074714
申请日：2016-03-18
摘要： Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an SRPX.
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公开(公告)号：US11873494B2
公开(公告)日：2024-01-16
申请号：US17406441
申请日：2021-08-19
发明人： Michael R. Green , Minggang Fang
IPC分类号： C07K14/47 , C12N15/113 , A61K45/06
CPC分类号： C12N15/1137 , C07K14/47 , A61K45/06 , C12N2310/11 , C12N2310/14
摘要： Methods of treating subjects having disorders associated with mutations in the FXN gene and/or having reduced expression of frataxin protein, e.g., Friedreich ataxia (FA). Generally, the methods include administering a therapeutically effective amount of an agent that increases expression of frataxin protein as described herein, e.g., an inhibitor of a FXN Repressing Factor (FXN-RF).
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公开(公告)号：US20230416779A1
公开(公告)日：2023-12-28
申请号：US18311367
申请日：2023-05-03
CPC分类号： C12N15/86 , C07K14/4702 , C12N2750/14143 , C12N2310/141 , C12N2330/10 , C07K2319/41
摘要： In some aspects, the disclosure relates to compositions and methods of engineering a transgene. In some embodiments, the disclosure provides self-regulating recombinant nucleic acids, viral vectors and pharmaceutical compositions comprising a MeCP2 transgene. In some embodiments, compositions and methods described by the disclosure are useful for treating diseases and disorders associated with a loss of function mutation, for example Rett syndrome.
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公开(公告)号：US20210317529A9
公开(公告)日：2021-10-14
申请号：US16897549
申请日：2020-06-10
IPC分类号： C12Q1/6883 , G01N33/50
摘要： In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases.
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