公开(公告)号：US4099001A

公开(公告)日：1978-07-04

申请号：US777873

申请日：1977-03-15

Applicant: Hermann Breuer ,  Uwe D. Treuner

Inventor： Hermann Breuer ,  Uwe D. Treuner

IPC: C07D233/38 ,  C07D333/24 ,  C07D501/36

CPC classification number: C07D233/38 ,  C07D333/24

Abstract: [[[Imidazolidinyl amino]carbonyl]amino]acetylcephalosporin derivatives having the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen or methoxy; R.sub.2, R.sub.3 and R.sub.5 each is hydrogen or lower alkyl; R.sub.4 is hydrogen, lower alkyl, cyclo-lower alkyl, cyclo-lower alkenyl, cyclo-lower alkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R.sub.6 is lower alkyl; and X is hydrogen, lower alkanoyloxy, ##STR3## or certain heterothio groups; are useful as antibacterial agents.

公开(公告)号：US4096330A

公开(公告)日：1978-06-20

申请号：US789467

申请日：1977-04-21

Applicant: Uwe D. Treuner ,  Hermann Breuer

Inventor： Uwe D. Treuner ,  Hermann Breuer

IPC: A61K20060101 ,  C07D501/36 ,  C07G20060101

CPC classification number: C07C255/00

Abstract: 7.beta.-[[[(2-Cyanomethyl)amino]-1,2-dioxoethyl]amino]-acyl cephalosporins which have the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, tri(lower alkyl)stannyl, trihaloethyl or a salt forming ion; R.sub.1 is hydrogen, lower alkyl, saturated or unsaturated cycloalkyl, phenyl, phenyl-lower alkyl, substituted phenyl or certain heterocyclic groups; R.sub.2 is hydrogen or methoxy; R.sub.3 is hydrogen, lower alkyl, phenyl-lower alkyl or cycloalkyl; R.sub.4 and R.sub.5 each is hydrogen or lower alkyl; and X is hydrogen, lower alkanoyloxy, carbamoyloxy, lower alkoxy, lower alkylthio ##STR2## or certain heterothio groups, are useful as antibacterial agents.

Abstract translation: 7β-[[[（2-氰基甲基）氨基] -1,2-二氧代乙基]氨基] - 酰基头孢菌素，其具有式其中R是氢，低级烷基，苯基 - 低级烷基，二苯基 - 低级烷基， 三（低级烷基）甲硅烷基，三（低级烷基）甲锡烷基，三卤代乙基或成盐离子; R 1是氢，低级烷基，饱和或不饱和环烷基，苯基，苯基 - 低级烷基，取代的苯基或某些杂环基; R2是氢或甲氧基; R3是氢，低级烷基，苯基 - 低级烷基或环烷基; R4和R5各自为氢或低级烷基; X为氢，低级烷酰氧基，氨基甲酰氧基，低级烷氧基，低级烷硫基或某些杂硫基，可用作抗菌剂。

公开(公告)号：US4088816A

公开(公告)日：1978-05-09

申请号：US664796

申请日：1976-03-08

Applicant: Uwe D. Treuner ,  Hermann Breuer

Inventor： Uwe D. Treuner ,  Hermann Breuer

IPC: C07D213/55 ,  C07D333/24 ,  C07D501/36 ,  C07D501/56 ,  A61K31/545

CPC classification number: C07D333/24 ,  C07D213/55

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.4 represent certain heterocyclic groups; R.sub.2 is hydrogen or lower alkyl; and R.sub.3 is hydrogen, lower alkyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)stannyl, tri(lower alkyl)silyl, a salt forming ion, or the group ##STR2## wherein R is lower alkyl, phenyl, phenyl-lower alkyl, or substituted phenyl and phenyl-lower alkyl are disclosed. These compounds are useful as antibacterial agents.

Abstract translation: 其中R1和R4表示某些杂环基团的式“IMAGE”的化合物; R2是氢或低级烷基; 并且R 3是氢，低级烷基，苯基 - 低级烷基，取代的苯基 - 低级烷基，二苯基 - 低级烷基，三（低级烷基）甲锡烷基，三（低级烷基）甲硅烷基，成盐离子或基团< R是低级烷基，苯基，苯基 - 低级烷基或取代的苯基和苯基 - 低级烷基。 这些化合物可用作抗菌剂。

公开(公告)号：US4003893A

公开(公告)日：1977-01-18

申请号：US513978

申请日：1974-10-11

Applicant: Hermann Breuer ,  Uwe D. Treuner

Inventor： Hermann Breuer ,  Uwe D. Treuner

IPC: C07D501/36 ,  C07D501/50

CPC classification number: Y02A50/473 ,  Y02A50/481

Abstract: 3-Heterothio[(thioalkyl)thioacetyl]cephalosporin derivatives which have the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, a salt forming ion, or the group ##STR2## R.sub. 1 is hydrogen, lower alkyl, phenyl, thienyl of furyl; R.sub.2 and R.sub.6 each is hydrogen or lower alkyl; R.sub.3 and R.sub.5 each is lower alkyl, phenyl or phenyl-lower alkyl; and R.sub.4 is a five- or six-membered nitrogen and/or sulfur or oxygen-containing ring system; are useful as antibacterial agents.

Abstract translation: 具有下式的3-异硫代[（硫代烷基）硫代乙酰基]头孢菌素衍生物其中R是氢，低级烷基，苯基 - 低级烷基，三（低级烷基）甲硅烷基，成盐离子， 图像> R 1是氢，低级烷基，苯基，呋喃基的噻吩基; R2和R6各自为氢或低级烷基; R3和R5各自为低级烷基，苯基或苯基 - 低级烷基; 和R4是五或六元氮和/或硫或含氧环系; 作为抗菌剂是有用的。

公开(公告)号：US3978050A

公开(公告)日：1976-08-31

申请号：US544031

申请日：1975-01-24

Applicant: Uwe D. Treuner ,  Hermann Breuer

Inventor： Uwe D. Treuner ,  Hermann Breuer

IPC: C07D501/36 ,  C07D521/00

CPC classification number: C07D231/12 ,  C07C329/00 ,  C07D233/56 ,  C07D249/08

Abstract: 3-Heterothio derivatives of [[(alkoxy)thiocarbonyl]oxy]acetyl cephalosporins having the formula ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)stannyl, tri(lower alkyl)silyl, a salt forming ion or the group ##EQU2## R.sub.1 is hydrogen, lower alkyl, phenyl, pyridyl, thienyl or furyl; R.sub.2 is lower alkyl or phenyl-lower alkyl; R.sub.3 is 1-oxopyridinyl or a five membered heterocycle containing only nitrogen and carbon or nitrogen, carbon and oxygen or sulfur in the ring; R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

Abstract translation: 具有下列通式的[[（烷氧基）硫代羰基]氧基]乙酰头孢菌素的3-异硫脲衍生物ANGLE R1-CH-CO-NH-CH-CH-CH2 ||| OCO-R2||| PARALLEL C-NC- （低级烷基）甲硅烷基，三（低级烷基）甲硅烷基，成盐离子或基团O（C 1 -C 4）烷基， 平行-CH2-OC-R4; R 1是氢，低级烷基，苯基，吡啶基，噻吩基或呋喃基; R2是低级烷基或苯基 - 低级烷基; R 3是1-氧代吡啶基或在环中仅含有氮和碳或氮，碳和氧或硫的五元杂环; R4是低级烷基，苯基或苯基 - 低级烷基; 作为抗菌剂是有用的。

公开(公告)号：US3956290A

公开(公告)日：1976-05-11

申请号：US542329

申请日：1975-01-20

Applicant: Uwe D. Treuner ,  Hermann Breuer

Inventor： Uwe D. Treuner ,  Hermann Breuer

IPC: C07F9/6547 ,  C07D501/28

CPC classification number: C07F9/6547

Abstract: [(Thiophosphono)acetamido]cephalosporin derivatives of the general formula ##EQU1## wherein R is hydrogen, lower alkyl, aralkyl, tri(lower alkyl)silyl, tri(lower alkyl)stannyl, a salt forming ion or the group ##EQU2## R.sub.1 is hydrogen; R.sub.2, R.sub.3 and R.sub.4 each is lower alkyl, or aralkyl; and X is hydrogen, hydroxy or lower alkanoyloxy; are useful as antibacterial agents.

Abstract translation: [（硫代膦酰基）乙酰氨基]头孢菌素衍生物通式S ANGLE R1-CH-CO-NH-CH-CHCH2 | O-R2 || SP ANGLE ||| PARALLEL O-R3 C-NC-CH2- 其中R是氢，低级烷基，芳烷基，三（低级烷基）甲硅烷基，三（低级烷基）甲锡烷基，成盐离子或基团O并原-CH2-OC-R4的XS平行角OC; R1是氢; R2，R3和R4各自为低级烷基或芳烷基; X为氢，羟基或低级烷酰氧基; 作为抗菌剂是有用的。

公开(公告)号：US3946001A

公开(公告)日：1976-03-23

申请号：US471080

申请日：1974-05-17

Applicant: Uwe D. Treuner ,  Hermann Breuer

Inventor： Uwe D. Treuner ,  Hermann Breuer

IPC: C07D207/40 ,  C07D207/404 ,  C07D501/20 ,  C07D501/32

CPC classification number: C07D207/404 ,  C07C329/00

Abstract: (Carbamoylthioacetyl)cephalosporin derivatives of the general formula ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)stannyl, tri(lower alkyl)silyl, a salt forming ion or the group ##EQU2## R.sub.1 is hydrogen, lower alkyl, phenyl, thienyl or furyl; R.sub.2 is lower alkyl, lower alkoxymethyl, phenyl or phenyl-lower alkyl; R.sub.3 is hydrogen, hydroxy or lower alkanoyloxy; and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

Abstract translation: （氨基甲酰硫代乙酰基）头孢菌素衍生物S ANGLE R1-CH-CO-NH-CH-CHCH2 ||| SC-NH-R2并列C-NC-CH2-R3平行OO角C | C - （OR）其中R是氢，低级烷基，苯基 - 低级烷基，三（低级烷基）甲锡烷基，三（低级烷基）甲硅烷基，成盐离子或基团O并原-CH2-OC-R4; R 1是氢，低级烷基，苯基，噻吩基或呋喃基; R2是低级烷基，低级烷氧基甲基，苯基或苯基 - 低级烷基; R3是氢，羟基或低级烷酰氧基; 和R4是低级烷基，苯基或苯基 - 低级烷基; 作为抗菌剂是有用的。

公开(公告)号：US3931170A

公开(公告)日：1976-01-06

申请号：US501902

申请日：1974-08-30

Applicant: Uwe D. Treuner ,  Hermann Breuer

Inventor： Uwe D. Treuner ,  Hermann Breuer

IPC: A61K31/545 ,  C07D501/36 ,  C07D501/50

CPC classification number: C07D501/36

Abstract: 3-Heterothio(carbamoylthioacetyl)cephalosporin derivatives of the general formula ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, a salt forming ion or the group ##EQU2## R.sub.1 is hydrogen, lower alkyl, phenyl, thienyl, or pyridyl; R.sub.2 is lower alkyl or phenyl-lower alkyl; R.sub.3 is a five or six membered nitrogen, sulfur and/or oxygen containing ring system; and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

Abstract translation: 3-异硫代（氨基甲酰硫代乙酰基）头孢菌素衍生物通式S ANGLE R1-CH ------ CO-NH-CH-CHCH2 |||| SC-NH-R 2||| PARALLEL C-NC-CH2- S-R3平行平行OO角C | C或OR并行O其中R是氢，低级烷基，苯基 - 低级烷基，三（低级烷基）甲硅烷基，成盐离子或基团O并原-CH2-OC-R4; R 1是氢，低级烷基，苯基，噻吩基或吡啶基; R2是低级烷基或苯基 - 低级烷基; R3是五或六元氮，硫和/或含氧环系; 和R4是低级烷基，苯基或苯基 - 低级烷基; 作为抗菌剂是有用的。

公开(公告)号：US5266593A

公开(公告)日：1993-11-30

申请号：US906808

申请日：1992-06-30

Applicant: Peter Ermann ,  Henner Straub ,  Uwe D. Treuner ,  Jakob-Matthias Drossard

Inventor： Peter Ermann ,  Henner Straub ,  Uwe D. Treuner ,  Jakob-Matthias Drossard

IPC: C07D309/10 ,  A61K31/335

CPC classification number: C07D309/10

Abstract: Novel antibiotic substances, having the general formula ##STR1## wherein A, R.sub.1 and R.sub.2 are as defined herein.

Abstract translation: 具有通式为其中A，R 1和R 2如本文所定义的通式为“IMAGE”I的新型抗生素物质。

公开(公告)号：US5068331A

公开(公告)日：1991-11-26

申请号：US552038

申请日：1990-07-13

Applicant: Uwe D. Treuner

Inventor： Uwe D. Treuner

IPC: C07D401/12 ,  C07D401/14 ,  C07D417/14

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D417/14

Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, exhibit antibacterial activity wherein R is ##STR2##

Abstract translation: 具有式“IMAGE”的化合物及其药学上可接受的盐具有抗菌活性，其中R是