公开(公告)号：US4048166A

公开(公告)日：1977-09-13

申请号：US741089

申请日：1976-11-11

申请人： Albertha M. Paul ,  Charles E. Moppett

发明人： Albertha M. Paul ,  Charles E. Moppett

IPC分类号： A01N47/16 ,  A01N47/22 ,  C07D487/08 ,  C07D257/10 ,  C07D519/00

CPC分类号： C07D487/08 ,  A01N47/16 ,  A01N47/22

摘要： Compounds of the formula ##STR1## where X represents O or S and R represents C.sub.1-4 alkyl, phenyl or (C.sub.1-4 alkyl)phenyl. The compounds are prepared by reacting the ring-opened intermediate, obtained by reacting cis-1-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo (3.3.1.1.sup.3,7) decane chloride with excess aqueous sodium hydroxide, with an equivalent amount of a corresponding halide formate or halide thioformate, ClC=X(OR), at about 0.degree. C in the presenceof a hydrogen chloride acceptor and using a non-nucleophilic organic solvent as reaction medium. The carbamate products have antimicrobial utility.

摘要翻译： 式中，X表示O或S，R表示C 1-4烷基，苯基或（C 1-4烷基）苯基的化合物。 通过将顺式-1-（3-氯-2-丙烯基）-3,5,7-三氮杂-1-氮杂三环（3.3.1.13,7）癸烷氯与顺式-1-（3-氯-2-丙烯基）-3,5,7-三氮杂-1-氮杂三环（3.3.1.13,7）癸烷氯反应获得的开环中间体与 在约0℃下，在氯化氢受体存在下，并使用非亲核有机溶剂作为反应介质，过量的氢氧化钠水溶液与等量的相应的卤化甲酸盐或硫代甲酸卤化物ClC = X（OR）。 氨基甲酸酯产品具有抗菌效用。

公开(公告)号：USRE29226E

公开(公告)日：1977-05-17

申请号：US652608

申请日：1976-01-26

申请人： Albertha M. Paul nee Albertha B. Mitchell ,  Charles E. Moppett ,  Thomas P. Brady

发明人： Albertha M. Paul nee Albertha B. Mitchell ,  Charles E. Moppett ,  Thomas P. Brady

IPC分类号： C07D487/18

CPC分类号： C07D487/18

摘要： Compounds of the .[.formulas.]. .Iadd.formula .Iaddend. ##STR1## wherein X.sup.- is a lower alkyl carboxylate .[.(I).]., a phenylcarboxylate .[.(I).]., a lower alkylsulfonate .[.(II).]. or a phenylsulfonate .[.(II).]. anion, wherein the phenyl ring may have lower alkyl, lower alkoxy, hydroxyl, amino, nitro, bromo or chloro substitution. The compounds are prepared by reacting the .[.carbinolamine.]. .Iadd.ring-opened intermediate .Iaddend.prepared by reacting cis-1-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo(3.3.1.1.sup.3,7)decane chloride with aqueous sodium hydroxide, with a carboxylic or sulfonic acid, as indicated, to form the corresponding 1-cis-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo(3.3.1.1.sup.3,7)decane carboxylate or sulfonate. These compounds have antimicrobial activity.