公开(公告)号：USRE29226E

公开(公告)日：1977-05-17

申请号：US652608

申请日：1976-01-26

申请人： Albertha M. Paul nee Albertha B. Mitchell ,  Charles E. Moppett ,  Thomas P. Brady

发明人： Albertha M. Paul nee Albertha B. Mitchell ,  Charles E. Moppett ,  Thomas P. Brady

IPC分类号： C07D487/18

CPC分类号： C07D487/18

摘要： Compounds of the .[.formulas.]. .Iadd.formula .Iaddend. ##STR1## wherein X.sup.- is a lower alkyl carboxylate .[.(I).]., a phenylcarboxylate .[.(I).]., a lower alkylsulfonate .[.(II).]. or a phenylsulfonate .[.(II).]. anion, wherein the phenyl ring may have lower alkyl, lower alkoxy, hydroxyl, amino, nitro, bromo or chloro substitution. The compounds are prepared by reacting the .[.carbinolamine.]. .Iadd.ring-opened intermediate .Iaddend.prepared by reacting cis-1-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo(3.3.1.1.sup.3,7)decane chloride with aqueous sodium hydroxide, with a carboxylic or sulfonic acid, as indicated, to form the corresponding 1-cis-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo(3.3.1.1.sup.3,7)decane carboxylate or sulfonate. These compounds have antimicrobial activity.

公开(公告)号：USRE29225E

公开(公告)日：1977-05-17

申请号：US649173

申请日：1976-01-15

申请人： Albertha M. Paul nee Albertha B. Mitchell ,  Charles E. Moppett

发明人： Albertha M. Paul nee Albertha B. Mitchell ,  Charles E. Moppett

IPC分类号： C07D487/08

CPC分类号： C07D487/08

摘要： Compounds of the formula ##STR1## WHERE X represents O or S and R represents lower alkyl, cycloalkyl, phenyl or substituted phenyl wherein the substituents are selected from lower alkyl, lower alkoxy, halo and sulfonyl. The compounds are prepared by reacting the .[.carbinolamine.]. .Iadd.ring-opened intermediate,.Iaddend.obtained by reacting cis-1-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo (3,3,1,1.sup.3,7) decane chloride with excess aqueous sodium hydroxide, with an equivalent amount of a corresponding R isocyanate or R isothiocyanate at a low temperature to give the substituted urea or thiourea product. The compounds have antimicrobial activity.