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21.发明授权Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use 有权酸基取代的二苯基氮杂环丁酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US07388004B2
公开(公告)日：2008-06-17
申请号：US11643890
申请日：2006-12-22
申请人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
发明人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
IPC分类号： C07D205/08 , C07F9/568 , A61K31/397 , A61P9/10 , A61P3/06
CPC分类号： C07D205/08
摘要： One embodiment of the invention relates to compounds of the formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of the compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
摘要翻译： 本发明的一个实施方案涉及式I化合物：其中R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义。 本发明的其它实施方案涉及式I化合物的生理上可接受的盐，其制备方法和包含这些化合物的药物。 本发明的化合物适合用作例如降血脂药。
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22.发明授权Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use 有权环取代的二苯基氮杂环丁酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US07579339B2
公开(公告)日：2009-08-25
申请号：US11501758
申请日：2006-08-10
申请人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
发明人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
IPC分类号： C07D205/08 , C07D227/00 , A61K31/397 , A61P3/06 , A61P9/10
CPC分类号： C07D403/12 , C07D205/08 , C07D453/02 , C07D487/08 , Y10S930/28
摘要： One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
摘要翻译： 本发明的一个实施方案涉及式I化合物，其中R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义。 本发明的其它实施方案涉及式I化合物的生理上可接受的盐，其制备方法和包含这些化合物的药物。 本发明的化合物适合用作例如降血脂药。
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公开(公告)号：US07390790B2
公开(公告)日：2008-06-24
申请号：US11544718
申请日：2006-10-10
申请人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
发明人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
IPC分类号： A61K31/7052 , C07H7/02 , C07H7/04 , A61P3/06 , A61P9/10 , A61K31/397 , C07D205/08 , C07D227/00
CPC分类号： C07D403/12 , C07D205/08 , C07D453/02 , C07D487/08 , Y10S930/28
摘要： One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
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24.发明申请Acid-group-substituted diphenylazetidinones process for their preparation, medicaments comprising these compounds, and their use 有权酸组取代的二苯基氮杂环丁烷的制备方法，包含这些化合物的药物及其用途公开(公告)号：US20070123506A1
公开(公告)日：2007-05-31
申请号：US11643890
申请日：2006-12-22
申请人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
发明人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
IPC分类号： A61K31/397 , A61K31/675 , C07D205/04
CPC分类号： C07D205/08
摘要： One embodiment of the invention relates to compounds of the formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of the compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
摘要翻译： 本发明的一个实施方案涉及式I化合物：其中R1，R2，R3，R4，R5和R6具有说明书中给出的含义。 本发明的其它实施方案涉及式I化合物的生理上可接受的盐，其制备方法和包含这些化合物的药物。 本发明的化合物适合用作例如降血脂药。
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公开(公告)号：US20070037787A1
公开(公告)日：2007-02-15
申请号：US11544746
申请日：2006-10-10
申请人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
发明人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
IPC分类号： A61K31/397 , C07D205/02 , C07D403/02
CPC分类号： C07D403/12 , C07D205/08 , C07D453/02 , C07D487/08 , Y10S930/28
摘要： One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
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公开(公告)号：US20060270613A1
公开(公告)日：2006-11-30
申请号：US11501758
申请日：2006-08-10
申请人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
发明人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
IPC分类号： A61K31/7052 , A61K31/397 , A61K31/675
CPC分类号： C07D403/12 , C07D205/08 , C07D453/02 , C07D487/08 , Y10S930/28
摘要： One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
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27.发明授权Combination product of a 1,4-benzothiepine 1,1-dioxide compound with at least one other active ingredient and the use of the product 有权1,4-苯并噻吩1,1-二氧化物化合物与至少一种其它活性成分的组合产物和产物的用途公开(公告)号：US07179792B2
公开(公告)日：2007-02-20
申请号：US10699967
申请日：2003-11-03
CPC分类号： A61K45/06 , A61K31/395 , A61K31/55 , A61K2300/00
摘要： The present invention is directed to a 1,4-benzothiepine 1,1-dioxide compound of formula I in which the radicals have the meanings defined herein, or a pharmaceutically acceptable salt or physiologically functional derivative thereof, with at least one other active ingredient, or a pharmaceutically acceptable salt or physiologically functional derivative thereof. The invention is also directed to the use of the combination product, pharmaceutical composition comprising the combination product and method for preparing the pharmaceutical composition.
摘要翻译： 本发明涉及其中基团具有本文定义的含义，或其药学上可接受的盐或生理功能衍生物的式I的1,4-苯并硫代1,1-二氧化物化合物与至少一种其它活性成分， 或其药学上可接受的盐或生理功能衍生物。 本发明还涉及组合产品，包含组合产品和方法的药物组合物用于制备药物组合物的用途。
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28.发明申请NOVEL FLUOROGLYCOSIDE DERIVATIVES OF PYRAZOLES, MEDICAMENTS CONTAINING THESE COMPOUNDS, AND THE USE THEREOF 有权吡咯烷酮的新型荧光素衍生物，含有这些化合物的药物及其用途公开(公告)号：US20070197623A1
公开(公告)日：2007-08-23
申请号：US11567410
申请日：2006-12-06
申请人： Harm BRUMMERHOP , Wendelin Frick , Heiner Glombik , Oliver Plettenburg , Martin Bickel , Hubert Heuer , Stefan Theis
发明人： Harm BRUMMERHOP , Wendelin Frick , Heiner Glombik , Oliver Plettenburg , Martin Bickel , Hubert Heuer , Stefan Theis
IPC分类号： A61K31/4155 , C07D231/12
CPC分类号： C07H17/02
摘要： The invention relates to substituted fluoroglycoside derivatives of pyrazoles of formula (I) as further defined in the specification, to the physiologically compatible salts thereof, to a method for their production, and to their use as antidiabetics.
摘要翻译： 本发明涉及在说明书中进一步定义的式（I）的吡唑的取代的氟代糖苷衍生物与其生理上相容的盐，其生产方法及其作为抗糖尿病药物的用途。
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29.发明授权Thiophene glycoside derivatives, processes for the preparation, medicaments comprising these compounds, and the use thereof 有权噻吩糖苷衍生物，制备方法，包含这些化合物的药物及其用途公开(公告)号：US07666848B2
公开(公告)日：2010-02-23
申请号：US11464338
申请日：2006-08-14
申请人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
发明人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
CPC分类号： A61K45/06 , A61K31/7042 , C07H17/00 , A61K2300/00
摘要： Novel thiophene glycoside derivatives of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for their preparation are disclosed. The compounds are suitable, for example, as antidiabetics.
摘要翻译： 公开了具有所述含义的式I的新型噻吩糖苷衍生物及其生理学上可耐受的盐及其制备方法。 该化合物例如适合作为抗糖尿病药。
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30.发明授权Thiophene glycoside derivatives, processes for the preparation, medicaments comprising these compounds, and the use thereof 有权噻吩糖苷衍生物，制备方法，包含这些化合物的药物及其用途公开(公告)号：US07101856B2
公开(公告)日：2006-09-05
申请号：US10616945
申请日：2003-07-11
申请人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
发明人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
CPC分类号： A61K45/06 , A61K31/7042 , C07H17/00 , A61K2300/00
摘要： Novel thiophene glycoside derivatives of the formula I: in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for their preparation are disclosed. The compounds are suitable, for example, as antidiabetics.
摘要翻译： 公开了具有所述含义的式I的新型噻吩糖苷衍生物及其生理上耐受的盐及其制备方法。 该化合物例如适合作为抗糖尿病药。
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