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1.发明授权Fluoroglycoside derivatives of pyrazoles, medicaments containing these compounds, and the use thereof 有权吡唑类氟草甘膦衍生物，含有这些化合物的药物及其用途公开(公告)号：US07820804B2
公开(公告)日：2010-10-26
申请号：US11567410
申请日：2006-12-06
申请人： Harm Brummerhop , Wendeline Frick , Heiner Glombik , Oliver Plettenburg , Martin Bickel , Hubert Heuer , Stefan Theis
发明人： Harm Brummerhop , Wendeline Frick , Heiner Glombik , Oliver Plettenburg , Martin Bickel , Hubert Heuer , Stefan Theis
IPC分类号： C07H17/02 , C07H17/00 , A61K31/7056
CPC分类号： C07H17/02
摘要： The invention relates to substituted fluoroglycoside derivatives of pyrazoles of formula (I) as further defined in the specification, to the physiologically compatible salts thereof, to a method for their production, and to their use as antidiabetics.
摘要翻译： 本发明涉及在说明书中进一步定义的式（I）的吡唑的取代的氟代糖苷衍生物与其生理上相容的盐，其生产方法及其作为抗糖尿病药物的用途。
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2.发明申请USE OF SUBSTITUTED PYRANONE ACID DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME 有权使用替代吡咯烷酮衍生物治疗代谢综合征公开(公告)号：US20100144862A1
公开(公告)日：2010-06-10
申请号：US12504198
申请日：2009-07-16
申请人： Harm BRUMMERHOP , Siegfried STENGELIN , Hubert HEUER , Susanne KILP , Andreas HERLING , Thomas KLABUNDE , Dieter KADEREIT , Matthias URMANN
发明人： Harm BRUMMERHOP , Siegfried STENGELIN , Hubert HEUER , Susanne KILP , Andreas HERLING , Thomas KLABUNDE , Dieter KADEREIT , Matthias URMANN
IPC分类号： A61K31/351 , C07D309/40 , C07D309/38 , A61P1/04 , A61P3/04 , A61P3/10 , A61P9/10 , A61P3/06 , A61P1/18 , A61P35/00 , A61P25/28 , A61P25/16 , A61P17/10 , A61P17/00 , A61P11/06
CPC分类号： A61K31/351
摘要： The invention relates to the use of substituted pyranone acid derivatives and of their physiologically acceptable salts for producing medicaments for treating the metabolic syndrome.
摘要翻译： 本发明涉及取代的吡喃酮酸衍生物及其生理学上可接受的盐用于制备用于治疗代谢综合征的药物的用途。
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3.发明授权Use of substituted cyclopropane acid derivatives for producing drugs for use in the treatment of metabolic syndrome 有权使用取代的环丙烷酸衍生物生产用于治疗代谢综合征的药物公开(公告)号：US08222240B2
公开(公告)日：2012-07-17
申请号：US12328052
申请日：2008-12-04
IPC分类号： A61K31/33
CPC分类号： A61K31/215
摘要： The present invention comprises methods for reducing plasma lipids, plasma free fatty acids (FFA), plasma glycerol and triglycerides in a mammal through the administration of certain substituted cyclopropane acid derivatives of Formula 1: wherein R1-R6 are defined herein and pharmaceutical compositions comprising them.
摘要翻译： 本发明包括通过施用式1的某些取代的环丙烷酸衍生物来降低哺乳动物血浆脂质，血浆游离脂肪酸（FFA），血浆甘油和甘油三酸酯的方法：其中R1-R6在本文中定义，并且药物组合物包含它们 。
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4.发明申请USE OF SUBSTITUTED CYCLOPROPANE ACID DERIVATIVES FOR PRODUCING DRUGS FOR USE IN THE TREATMENT OF METABOLIC SYNDROME 有权用于生产用于治疗代谢综合征的药物的替代环丙磺酸衍生物的使用公开(公告)号：US20090088474A1
公开(公告)日：2009-04-02
申请号：US12328052
申请日：2008-12-04
IPC分类号： A61K31/21
CPC分类号： A61K31/215
摘要： The present invention comprises methods for reducing plasma lipids, plasma free fatty acids (FFA), plasma glycerol and triglycerides in a mammal through the administration of certain substituted cyclopropane acid derivatives of Formula 1: wherein R1-R6 are defined herein and pharmaceutical compositions comprising them.
摘要翻译： 本发明包括通过施用式1的某些取代的环丙烷酸衍生物来降低哺乳动物血浆脂质，血浆游离脂肪酸（FFA），血浆甘油和甘油三酸酯的方法：其中R1-R6在本文中定义，并且药物组合物包含它们 。
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5.发明申请NOVEL AROMATIC FLUOROGLYCOSIDE DERIVATIVES, MEDICAMENTS CONTAINING THESE COMPOUNDS, AND THE USE THEREOF 审中-公开新型芳香族氟化物衍生物，含有这些化合物的药物及其用途公开(公告)号：US20080108580A1
公开(公告)日：2008-05-08
申请号：US11926697
申请日：2007-10-29
申请人： Wendelin FRICK , Heiner Glombik , Werner Kramer , Hubert Heuer , Harm Brummerhop , Oliver Plettenburg
发明人： Wendelin FRICK , Heiner Glombik , Werner Kramer , Hubert Heuer , Harm Brummerhop , Oliver Plettenburg
IPC分类号： A61K31/7004 , C07H15/207 , A61P3/10
CPC分类号： C07H15/203
摘要： Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof. The invention relates to substituted aromatic fluoroglycoside derivatives of the formula I in which the radicals have the stated meanings, and their physiologically tolerated salts and process for their preparation. The compounds are suitable for example as antidiabetics.
摘要翻译： 新型芳香族氟代糖苷衍生物，含有这些化合物的药物及其用途。 本发明涉及其中基团具有所述含义的式I的取代芳族氟代糖苷衍生物及其生理学耐受盐及其制备方法。 该化合物适合于例如抗糖尿病药。
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6.发明授权Aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof 有权芳香族氟代糖苷衍生物，含有这些化合物的药物及其用途公开(公告)号：US07288528B2
公开(公告)日：2007-10-30
申请号：US10735179
申请日：2003-12-12
申请人： Wendelin Frick , Heiner Glombik , Werner Kramer , Hubert Heuer , Harm Brummerhop , Oliver Plettenburg
发明人： Wendelin Frick , Heiner Glombik , Werner Kramer , Hubert Heuer , Harm Brummerhop , Oliver Plettenburg
CPC分类号： C07H15/203
摘要： Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof.The invention relates to substituted aromatic fluoroglycoside derivatives of the formula I in which the radicals have the stated meanings, and their physiologically tolerated salts and process for their preparation. The compounds are suitable for example as antidiabetics.
摘要翻译： 新型芳香族氟代糖苷衍生物，含有这些化合物的药物及其用途。 本发明涉及其中基团具有所述含义的式I的取代芳族氟代糖苷衍生物及其生理学耐受盐及其制备方法。 该化合物适合于例如抗糖尿病药。
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7.发明授权Thiophene glycoside derivatives, processes for the preparation, medicaments comprising these compounds, and the use thereof 有权噻吩糖苷衍生物，制备方法，包含这些化合物的药物及其用途公开(公告)号：US07666848B2
公开(公告)日：2010-02-23
申请号：US11464338
申请日：2006-08-14
申请人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
发明人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
CPC分类号： A61K45/06 , A61K31/7042 , C07H17/00 , A61K2300/00
摘要： Novel thiophene glycoside derivatives of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for their preparation are disclosed. The compounds are suitable, for example, as antidiabetics.
摘要翻译： 公开了具有所述含义的式I的新型噻吩糖苷衍生物及其生理学上可耐受的盐及其制备方法。 该化合物例如适合作为抗糖尿病药。
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8.发明申请USE OF SUBSTITUTED CYCLOPROPANE ACID DERIVATIVES FOR PRODUCING DRUGS FOR USE IN THE TREATMENT OF METABOLIC SYNDROME 审中-公开用于生产用于治疗代谢综合征的药物的替代环丙磺酸衍生物的使用公开(公告)号：US20080045590A1
公开(公告)日：2008-02-21
申请号：US11759510
申请日：2007-06-07
IPC分类号： A61K31/225 , A61P3/00
CPC分类号： A61K31/215
摘要： Disclosed is the use of certain substituted cyclopropane acid derivatives of Formula 1 as defined herein and of their physiologically tolerated salts for treating metabolic syndrome and related disorders.
摘要翻译： 公开了本文定义的某些式1的取代环丙烷酸衍生物及其生理学耐受盐用于治疗代谢综合征和相关病症的用途。
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9.发明授权Thiophene glycoside derivatives, processes for the preparation, medicaments comprising these compounds, and the use thereof 有权噻吩糖苷衍生物，制备方法，包含这些化合物的药物及其用途公开(公告)号：US07101856B2
公开(公告)日：2006-09-05
申请号：US10616945
申请日：2003-07-11
申请人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
发明人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
CPC分类号： A61K45/06 , A61K31/7042 , C07H17/00 , A61K2300/00
摘要： Novel thiophene glycoside derivatives of the formula I: in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for their preparation are disclosed. The compounds are suitable, for example, as antidiabetics.
摘要翻译： 公开了具有所述含义的式I的新型噻吩糖苷衍生物及其生理上耐受的盐及其制备方法。 该化合物例如适合作为抗糖尿病药。
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10.发明授权Use of substituted pyranone acid derivatives for the treatment of metabolic syndrome 有权使用取代的吡喃酮酸衍生物治疗代谢综合征公开(公告)号：US08748483B2
公开(公告)日：2014-06-10
申请号：US12504198
申请日：2009-07-16
申请人： Harm Brummerhop , Siegfried Stengelin , Hubert Heuer , Susanne Kilp , Andreas Herling , Thomas Klabunde , Dieter Kadereit , Matthias Urmann
发明人： Harm Brummerhop , Siegfried Stengelin , Hubert Heuer , Susanne Kilp , Andreas Herling , Thomas Klabunde , Dieter Kadereit , Matthias Urmann
IPC分类号： A01N43/16 , A61K31/35 , C09B3/00 , C07D209/80 , C09B7/00
CPC分类号： A61K31/351
摘要： The invention relates to the use of substituted pyranone acid derivatives and of their physiologically acceptable salts for producing medicaments for treating the metabolic syndrome.
摘要翻译： 本发明涉及取代的吡喃酮酸衍生物及其生理学上可接受的盐用于制备用于治疗代谢综合征的药物的用途。
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