公开(公告)号：US20080221430A1

公开(公告)日：2008-09-11

申请号：US12030893

申请日：2008-02-14

申请人： Hisaaki OCHI ,  Yo Taniguchi ,  Yoshihisa Soutome ,  Yoshitaka Bito

发明人： Hisaaki OCHI ,  Yo Taniguchi ,  Yoshihisa Soutome ,  Yoshitaka Bito

IPC分类号： A61B5/055

CPC分类号： G01R33/5601 ,  G01R33/54 ,  G01R33/5616 ,  G01R33/5617

摘要： A magnetic resonance imaging (MRI) apparatus for high-speed and high-accuracy detection of cell positions labeled with magnetic nanoparticles. A transmitter coil is controlled to generate amplitude-modulated burst RF pulses as excitation RF pulses whose amplitude is modulated by a function that repeatedly inverts the polarity of multiple high-frequency magnetic field sub-pulses separated time-wise and changes the amplitude at each polarity inversion, moreover the time interval of the amplitude-modulated burst RF pulse is set to effectively 1/(2×a first frequency), and the transmitter coil controlled so the carrier frequency of the amplitude-modulated burst RF pulse is set to a second frequency shifted substantially from the first frequency of the magnetic resonance frequency of the proton at the magnetic field strength in the MRI apparatus. The first frequency is here determined based on magnetic nanoparticle information loaded from the magnetic nanoparticle information storage unit and the magnetic resonance frequency of the proton in the static magnetic field. The MRI apparatus can in this way detect the position of cells labeled with magnetic nanoparticles, with high-speed and high accuracy.

摘要翻译： 一种磁共振成像（MRI）装置，用于高速和高精度检测用磁性纳米颗粒标记的细胞位置。 发射器线圈被控制以产生幅度调制的突发RF脉冲作为激励RF脉冲，其幅度通过重复地反转时间间隔分离的多个高频磁场子脉冲的极性并改变每个极性的振幅的函数来调制 此外，调幅脉冲串RF脉冲的时间间隔被有效地设置为1 /（2×a第一频率），并且被控制的发射机线圈被调制的调幅脉冲串RF脉冲的载波频率设置为第二频移 基本上从MRI装置中的磁场强度的质子的磁共振频率的第一频率开始。 这里基于从磁性纳米颗粒信息存储单元加载的磁性纳米颗粒信息和静态磁场中质子的磁共振频率来确定第一频率。 MRI装置可以以这种方式以高速和高精度检测用磁性纳米颗粒标记的细胞的位置。

公开(公告)号：US20120299594A1

公开(公告)日：2012-11-29

申请号：US13577885

申请日：2011-01-21

申请人： Hideta Habara ,  Yoshitaka Bito ,  Hisaaki Ochi ,  Yoshihisa Soutome ,  Masayoshi Dohata ,  Tetsuhiko Takahashi ,  Hiroyuki Takeuchi

发明人： Hideta Habara ,  Yoshitaka Bito ,  Hisaaki Ochi ,  Yoshihisa Soutome ,  Masayoshi Dohata ,  Tetsuhiko Takahashi ,  Hiroyuki Takeuchi

IPC分类号： G01R33/28

CPC分类号： G01R33/34046

摘要： There is provided a technique for securing a comfortable examination space in a tunnel type MRI apparatus without increasing the manufacturing cost of the MRI apparatus and sacrificing performance thereof. In an RF coil provided with a hollow-shaped outer conductive element and a strip-shaped conductive element disposed along the outer conductive element in the axial direction, meander lines constituting the strip-shaped conductive element are disposed at uneven distances from the outer conductive element to secure an internal space. In order to obtain uniform sensitivity at the center of the RF coil, the strip-shaped conductive element is constituted with N of connected meander lines, and length of the strip-shaped conductive element is adjusted so that, in the strip-shaped conductive element resonating at resonance frequency of the antenna, nodes are formed in a number of (M+1)×N−1, wherein M is 0 or a natural number of 1 or larger.

摘要翻译： 提供了一种用于在隧道式MRI装置中确保舒适检查空间而不增加MRI装置的制造成本并牺牲其性能的技术。 在具有中空状的外部导电元件的RF线圈和沿着外部导电元件沿轴向设置的条状导电元件，构成条形导电元件的曲折线设置在与外部导电元件不均匀的距离处 以确保内部空间。 为了在RF线圈的中心获得均匀的灵敏度，带状导电元件由N个连接的曲折线构成，并且条形导电元件的长度被调节，使得在带状导电元件 在天线的谐振频率下共振，以（M + 1）×N-1的数量形成节点，其中M为0或自然数为1或更大。

公开(公告)号：US07639012B2

公开(公告)日：2009-12-29

申请号：US12071795

申请日：2008-02-26

申请人： Hideta Habara ,  Yoshitaka Bito ,  Yoshihisa Soutome ,  Hisaaki Ochi

发明人： Hideta Habara ,  Yoshitaka Bito ,  Yoshihisa Soutome ,  Hisaaki Ochi

IPC分类号： G01V3/00

CPC分类号： G01R33/34076 ,  G01R33/34007 ,  G01R33/3635

摘要： There is provided an RF coil capable of resonating or tuning two frequencies, having uniform spatial sensitivity and having a small spatially occupied volume, especially an RF coil suitable for a high magnetic field MRI apparatus. A coil apparatus is made up of a plurality of linear conductors 200, 201 arranged around a central axis and two ring conductors 202, 203 connected to the respective ends of the plurality of linear conductors 200, 201 and capacitors are inserted in the linear conductors 200, 201 and ring conductors 202, 203. The plurality of linear conductors are made up of conductors 200 located near the central axis and conductors 201 located far from the central axis and the ring conductors 202, 203 have star-like polygonal shape so that the linear conductors are arranged alternately. This structure can realize two tuning modes; a resonance mode similar to a birdcage type resonance mode and a resonance mode which becomes zero (node) in the vicinity of the linear conductor group 200 located near the central axis.

摘要翻译： 提供了能够谐振或调谐两个频率的RF线圈，其具有均匀的空间灵敏度并且具有小的空间占用体积，特别是适用于高磁场MRI装置的RF线圈。 线圈装置由围绕中心轴线布置的多个线性导体200,201和连接到多个线性导体200,201的各个端部的两个环形导体202,203组成，并且电容器插入线性导体200 ，201和环形导体202,203。多个线性导体由位于中心轴附近的导体200和位于远离中心轴线的导体201组成，并且环形导体202,203具有星形多边形形状，使得 线性导体交替排列。 该结构可实现两种调谐方式; 类似于鸟笼型共振模式的谐振模式和在位于中心轴附近的线性导体组200附近变为零（节点）的谐振模式。

公开(公告)号：US07589530B2

公开(公告)日：2009-09-15

申请号：US11936885

申请日：2007-11-08

申请人： Hideta Habara ,  Yoshitaka Bito ,  Yoshihisa Soutome ,  Hisaaki Ochi

发明人： Hideta Habara ,  Yoshitaka Bito ,  Yoshihisa Soutome ,  Hisaaki Ochi

IPC分类号： G01V3/00

CPC分类号： G01R33/34046 ,  G01R33/3635

摘要： An RF coil which is resonant and tuned with two different frequencies, has uniform space sensitivity and occupies less space is provided. The coil is, particularly suited to the high magnetic field MRI apparatus. The coil device is equipped with the multiple number of first coils 200 having the first conducting sections 201 and 202 and the second conducting sections 203 and 204, and the second coils 205 and 206 electrically connected with the end of the multiple number of first coils. In the first conducting sections, two conducting parts 201 and 202 are electrically connected via the first condenser 207, while in the second conducting sections, two conducting parts 203 and 204 are electrically connected via the second condenser 208. And the feeding circuit and/or receiving circuit are connected in parallel with the first condenser at one or two positions. By adjusting the capacity of the first and the second condenser, the RF coil having a uniform sensitivity range at two different frequencies can be configured.

摘要翻译： 谐振和调谐两种不同频率的RF线圈具有均匀的空间灵敏度，占用较少的空间。 该线圈特别适用于高磁场MRI装置。 线圈装置配备有多个具有第一导电部分201和202以及第二导电部分203和204的第一线圈200，并且第二线圈205和206与多个第一线圈的端部电连接。 在第一导电部分中，两个导电部分201和202经由第一电容器207电连接，而在第二导电部分中，两个导电部分203和204经由第二电容器208电连接。并且馈电电路和/或 接收电路在一个或两个位置与第一电容器并联连接。 通过调整第一和第二电容器的容量，可以配置具有两个不同频率的均匀灵敏度范围的RF线圈。

公开(公告)号：US09638771B2

公开(公告)日：2017-05-02

申请号：US13811979

申请日：2011-07-25

申请人： Yoshihisa Soutome ,  Yoshitaka Bito ,  Hiroyuki Takeuchi ,  Tetsuhiko Takahashi ,  Hisaaki Ochi ,  Hideta Habara

发明人： Yoshihisa Soutome ,  Yoshitaka Bito ,  Hiroyuki Takeuchi ,  Tetsuhiko Takahashi ,  Hisaaki Ochi ,  Hideta Habara

IPC分类号： G01R33/34 ,  A61B5/055 ,  G01R33/345 ,  G01R33/36 ,  G01R33/422

CPC分类号： G01R33/34 ,  A61B5/055 ,  G01R33/34046 ,  G01R33/34084 ,  G01R33/3453 ,  G01R33/365 ,  G01R33/3657 ,  G01R33/3678 ,  G01R33/422

摘要： A technique is provided to reserve large examination space in the tunnel type MRI apparatus, without increasing production cost nor reducing significantly irradiation efficiency and homogeneity in an irradiation distribution within an imaging region. The present invention provides an RF coil unit in which four partial cylindrical coils are placed with a gap therebetween in the circumferential direction inside a cylindrical RF shield, in such a manner that two pairs of the partial cylindrical coils are opposed to each other, and magnetic fields produced by the individual partial cylindrical coils are combined, thereby producing a circularly polarized wave field or an elliptically polarized wave field. The partial cylindrical coil is provided with a partial cylindrical conductor, multiple first conductors substantially parallel with the central axis of the RF shield, multiple capacitors connecting both ends of the first conductors with the partial cylindrical conductor, and a second conductor adjacent to at least one of the ends of the first conductor. The partial cylindrical coils are respectively provided with high frequency signals having a desired amplitude ratio and phase difference, while a reference frequency thereof being identical.

公开(公告)号：US08648597B2

公开(公告)日：2014-02-11

申请号：US12702666

申请日：2010-02-09

申请人： Hideta Habara ,  Yoshitaka Bito ,  Hisaaki Ochi ,  Yoshihisa Soutome ,  Masayoshi Dohata ,  Tetsuhiko Takahashi ,  Hiroyuki Takeuchi

发明人： Hideta Habara ,  Yoshitaka Bito ,  Hisaaki Ochi ,  Yoshihisa Soutome ,  Masayoshi Dohata ,  Tetsuhiko Takahashi ,  Hiroyuki Takeuchi

IPC分类号： G01R33/34

CPC分类号： G01R33/3456

摘要： An RF coil is provided with a hollow-shaped outer conductive element and strip-shaped conductive elements disposed along the outer conductive element in the axial direction. The strip-shaped conductive elements are disposed with uneven intervals to secure an internal space at a position where the strip-shaped conductive elements are not disposed. In order to obtain uniform sensitivity at the center section of the RF coil, the strip-shaped conductive elements and the outer conductive element are electrically connected via capacitors of which capacitances are adjusted so that a magnetic field component perpendicular to the center axis should be generated at a desired resonance frequency, and the strip-shaped conductive elements are axisymmetrically disposed with respect to the center axis of the outer conductive element. As a result, a comfortable examination space in a tunnel type MRI apparatus is achieved without increasing the manufacturing cost of the MRI apparatus.

摘要翻译： RF线圈设置有中空形的外导电元件和沿轴向方向沿着外导电元件设置的条形导电元件。 带状导电元件以不均匀的间隔设置，以将内部空间固定在未设置条形导电元件的位置。 为了在RF线圈的中心部分获得均匀的灵敏度，条状导电元件和外部导电元件通过电容被调节的电容器电连接，使得应当产生垂直于中心轴的磁场分量 并且所述带状导电元件相对于外导电元件的中心轴线对称设置。 结果，在不增加MRI装置的制造成本的情况下实现隧道式MRI装置中的舒适的检查空间。

公开(公告)号：US20130119991A1

公开(公告)日：2013-05-16

申请号：US13811979

申请日：2011-07-25

申请人： Yoshihisa Soutome ,  Yoshitaka Bito ,  Hiroyuki Takeuchi ,  Tetsuhiko Takahashi ,  Hisaaki Ochi ,  Hideta Habara

发明人： Yoshihisa Soutome ,  Yoshitaka Bito ,  Hiroyuki Takeuchi ,  Tetsuhiko Takahashi ,  Hisaaki Ochi ,  Hideta Habara

IPC分类号： G01R33/34

CPC分类号： G01R33/34 ,  A61B5/055 ,  G01R33/34046 ,  G01R33/34084 ,  G01R33/3453 ,  G01R33/365 ,  G01R33/3657 ,  G01R33/3678 ,  G01R33/422

摘要： A technique is provided to reserve large examination space in the tunnel type MRI apparatus, without increasing production cost nor reducing significantly irradiation efficiency and homogeneity in an irradiation distribution within an imaging region. The present invention provides an RF coil unit in which four partial cylindrical coils are placed with a gap therebetween in the circumferential direction inside a cylindrical RF shield, in such a manner that two pairs of the partial cylindrical coils are opposed to each other, and magnetic fields produced by the individual partial cylindrical coils are combined, thereby producing a circularly polarized wave field or an elliptically polarized wave field. The partial cylindrical coil is provided with a partial cylindrical conductor, multiple first conductors substantially parallel with the central axis of the RF shield, multiple capacitors connecting both ends of the first conductors with the partial cylindrical conductor, and a second conductor adjacent to at least one of the ends of the first conductor. The partial cylindrical coils are respectively provided with high frequency signals having a desired amplitude ratio and phase difference, while a reference frequency thereof being identical.

摘要翻译： 提供了一种在隧道式MRI装置中预留大的检查空间的技术，而不增加成本区域内的照射分布的生产成本，降低照射效率和均匀性。 本发明提供了一种RF线圈单元，其中四个部分圆柱形线圈在圆柱形RF屏蔽内沿圆周方向放置有间隙，使得两对部分圆柱形线圈彼此相对，并且磁性 由各个部分圆柱形线圈产生的磁场组合，从而产生圆偏振波场或椭圆偏振波场。 部分圆柱形线圈设置有部分圆柱形导体，多个第一导体基本上平行于RF屏蔽的中心轴线，多个电容器连接第一导体的两端与部分圆柱形导体，第二导​​体与至少一个 的第一导体的端部。 部分圆柱形线圈分别设置有具有期望的振幅比和相位差的高频信号，而其参考频率相同。

公开(公告)号：US20120262173A1

公开(公告)日：2012-10-18

申请号：US13512090

申请日：2010-11-29

申请人： Yoshihisa Soutome ,  Hideta Habara ,  Yoshitaka Bito ,  Hiroyuki Takeuchi ,  Tetsuhiko Takahashi ,  Hisaaki Ochi

发明人： Yoshihisa Soutome ,  Hideta Habara ,  Yoshitaka Bito ,  Hiroyuki Takeuchi ,  Tetsuhiko Takahashi ,  Hisaaki Ochi

IPC分类号： G01R33/34 ,  G01R33/48

CPC分类号： G01R33/34046 ,  G01R33/34053 ,  G01R33/34076 ,  G01R33/3453 ,  G01R33/3657 ,  G01R33/3678

摘要： There is provided a technique for securing a large examination space in a tunnel type MRI device without inviting increase of manufacturing cost and without significantly reducing irradiation efficiency or uniformity of the irradiation intensity distribution in an imaging region. Between rungs of a partially cylindrical RF coil, which coil corresponds to a cylindrical RF coil of which part is removed, there are disposed half-loops generating magnetic fields, which are synthesized with magnetic fields generated by loops constituted by adjacent rungs of the partially cylindrical RF coil and rings connecting the rungs to generate a circularly polarized or elliptically polarized magnetic field. Further, high-frequency signals of the same reference frequency having a desired amplitude ratio and phase difference are supplied to the partially cylindrical RF coils and half-loops.

摘要翻译： 提供了一种用于在隧道式MRI装置中确保大的检查空间的技术，而不会增加制造成本，并且不显着降低成像区域中的照射强度分布的照射效率或均匀性。 在部分圆柱形RF线圈的两个梯级之间，该线圈对应于部分被去除的圆柱形RF线圈，设置有产生磁场的半环，该磁场由具有由部分圆柱形的相邻梯级构成的环产生的磁场合成 RF线圈和环连接梯级以产生圆偏振或椭圆偏振磁场。 此外，具有期望幅度比和相位差的相同参考频率的高频信号被提供给部分圆柱形RF线圈和半环。

公开(公告)号：US20080150533A1

公开(公告)日：2008-06-26

申请号：US11936885

申请日：2007-11-08

申请人： Hideta Habara ,  Yoshitaka Bito ,  Yoshihisa Soutome ,  Hisaaki Ochi

发明人： Hideta Habara ,  Yoshitaka Bito ,  Yoshihisa Soutome ,  Hisaaki Ochi

IPC分类号： G01R33/34

CPC分类号： G01R33/34046 ,  G01R33/3635

摘要： An RF coil which is resonant and tuned with two different frequencies, has uniform space sensitivity and occupies less space is provided. The coil is, particularly suited to the high magnetic field MRI apparatus. The coil device is equipped with the multiple number of first coils 200 having the first conducting sections 201 and 202 and the second conducting sections 203 and 204, and the second coils 205 and 206 electrically connected with the end of the multiple number of first coils. In the first conducting sections, two conducting parts 201 and 202 are electrically connected via the first condenser 207, while in the second conducting sections, two conducting parts 203 and 204 are electrically connected via the second condenser 208. And the feeding circuit and/or receiving circuit are connected in parallel with the first condenser at one or two positions. By adjusting the capacity of the first and the second condenser, the RF coil having a uniform sensitivity range at two different frequencies can be configured.

摘要翻译： 谐振和调谐两种不同频率的RF线圈具有均匀的空间灵敏度，占用较少的空间。 该线圈特别适用于高磁场MRI装置。 线圈装置配备有多个具有第一导电部分201和202以及第二导电部分203和204的第一线圈200，并且第二线圈205和206与多个第一线圈的端部电连接。 在第一导电部分中，两个导电部分201和202经由第一电容器207电连接，而在第二导电部分中，两个导电部分203和204经由第二电容器208电连接。 并且馈送电路和/或接收电路在一个或两个位置处与第一冷凝器并联连接。 通过调整第一和第二电容器的容量，可以配置具有两个不同频率的均匀灵敏度范围的RF线圈。

公开(公告)号：US09274189B2

公开(公告)日：2016-03-01

申请号：US13512090

申请日：2010-11-29

申请人： Yoshihisa Soutome ,  Hideta Habara ,  Yoshitaka Bito ,  Hiroyuki Takeuchi ,  Tetsuhiko Takahashi ,  Hisaaki Ochi

发明人： Yoshihisa Soutome ,  Hideta Habara ,  Yoshitaka Bito ,  Hiroyuki Takeuchi ,  Tetsuhiko Takahashi ,  Hisaaki Ochi

IPC分类号： G01R33/34 ,  G01R33/48 ,  G01R33/345 ,  G01R33/36

CPC分类号： G01R33/34046 ,  G01R33/34053 ,  G01R33/34076 ,  G01R33/3453 ,  G01R33/3657 ,  G01R33/3678

摘要： There is provided a technique for securing a large examination space in a tunnel type MRI device without inviting increase of manufacturing cost and without significantly reducing irradiation efficiency or uniformity of the irradiation intensity distribution in an imaging region. Between rungs of a partially cylindrical RF coil, which coil corresponds to a cylindrical RF coil of which part is removed, there are disposed half-loops generating magnetic fields, which are synthesized with magnetic fields generated by loops constituted by adjacent rungs of the partially cylindrical RF coil and rings connecting the rungs to generate a circularly polarized or elliptically polarized magnetic field. Further, high-frequency signals of the same reference frequency having a desired amplitude ratio and phase difference are supplied to the partially cylindrical RF coils and half-loops.

摘要翻译： 提供了一种用于在隧道式MRI装置中确保大的检查空间的技术，而不会增加制造成本，并且不显着降低成像区域中的照射强度分布的照射效率或均匀性。 在部分圆柱形RF线圈的两个梯级之间，该线圈对应于部分被去除的圆柱形RF线圈，设置有产生磁场的半环，该磁场由具有由部分圆柱形的相邻梯级构成的环产生的磁场合成 RF线圈和环连接梯级以产生圆偏振或椭圆偏振磁场。 此外，具有期望幅度比和相位差的相同参考频率的高频信号被提供给部分圆柱形RF线圈和半环。