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公开(公告)号：US06645775B1
公开(公告)日：2003-11-11
申请号：US09723931
申请日：2000-11-28
IPC分类号： G01N33543
CPC分类号： C07K7/08 , A61K38/30 , C07K14/4743 , C07K2319/00 , Y10S930/12 , A61K2300/00
摘要： Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
摘要翻译： 提供了抑制IGF与其任何一种结合蛋白而不是人IGF受体的相互作用的化合物。 这些IGF激动剂化合物（其包括肽）可用于增加哺乳动物中活性IGF的血清和组织水平。
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公开(公告)号：US06608031B1
公开(公告)日：2003-08-19
申请号：US09723890
申请日：2000-11-28
IPC分类号： A61K3808
CPC分类号： C07K7/08 , A61K38/30 , C07K14/4743 , C07K2319/00 , Y10S930/12 , A61K2300/00
摘要： Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
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公开(公告)号：US6057292A
公开(公告)日：2000-05-02
申请号：US28587
申请日：1998-02-24
申请人： Brian C. Cunningham , Henry B. Lowman , James A. Wells , Ross G. Clark , Kenneth Olson , Germaine G. Fuh
发明人： Brian C. Cunningham , Henry B. Lowman , James A. Wells , Ross G. Clark , Kenneth Olson , Germaine G. Fuh
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K38/27 , A61K47/48 , A61P3/00 , A61P3/10 , A61P5/00 , A61P5/08 , A61P5/12 , A61P13/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07K1/107 , C07K14/61 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/18 , C12N15/63 , C12P21/02 , C12R1/19
CPC分类号： A61K47/48215 , C07K14/61 , A61K38/00 , C07K2319/00 , Y10S514/866 , Y10S930/12
摘要： Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugated to one or more chemical groups, such as poly(ethylene glycol), which is believed to prolong the in vivo half-life of the variants.
摘要翻译： 公开了对生长激素受体具有增强的亲和力的人生长激素变体。 还公开了与一种或多种化学基团缀合的人生长激素变体，例如聚（乙二醇），其被认为延长了变体的体内半衰期。
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公开(公告)号：US06949349B1
公开(公告)日：2005-09-27
申请号：US09724481
申请日：2000-11-28
IPC分类号： G01N33/566 , A61K31/427 , A61K31/4965 , A61K38/00 , A61K38/22 , A61K38/27 , A61K38/28 , A61K38/30 , A61K45/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P13/12 , A61P25/00 , C07K7/00 , C07K7/08 , C07K14/00 , C07K14/47 , C07K16/18 , C07K19/00 , C12N15/09 , C12Q1/70 , C07K14/435 , C07K14/65 , C12N7/01 , C12N15/63
CPC分类号： C07K7/08 , A61K38/30 , C07K14/4743 , C07K2319/00 , Y10S930/12 , A61K2300/00
摘要： Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
摘要翻译： 提供了抑制IGF与其任何一种结合蛋白而不是人IGF受体的相互作用的化合物。 这些IGF激动剂化合物（其包括肽）可用于增加哺乳动物中活性IGF的血清和组织水平。
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公开(公告)号：US06689751B1
公开(公告)日：2004-02-10
申请号：US09723912
申请日：2000-11-28
IPC分类号： A61K3810
CPC分类号： C07K7/08 , A61K38/30 , C07K14/4743 , C07K2319/00 , Y10S930/12 , A61K2300/00
摘要： Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
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公开(公告)号：US06680298B1
公开(公告)日：2004-01-20
申请号：US09724114
申请日：2000-11-28
IPC分类号： A61K3810
CPC分类号： C07K7/08 , A61K38/30 , C07K14/4743 , C07K2319/00 , Y10S930/12 , A61K2300/00
摘要： Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
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公开(公告)号：US5849535A
公开(公告)日：1998-12-15
申请号：US717394
申请日：1996-09-20
申请人： Brian C. Cunningham , Henry B. Lowman , James A. Wells , Ross G. Clark , Kenneth Olson , Germaine G. Fuh
发明人： Brian C. Cunningham , Henry B. Lowman , James A. Wells , Ross G. Clark , Kenneth Olson , Germaine G. Fuh
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K38/27 , A61K47/48 , A61P3/00 , A61P3/10 , A61P5/00 , A61P5/08 , A61P5/12 , A61P13/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07K1/107 , C07K14/61 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/18 , C12N15/63 , C12P21/02 , C12R1/19
CPC分类号： A61K47/48215 , C07K14/61 , A61K38/00 , C07K2319/00 , Y10S514/866 , Y10S930/12
摘要： Human growth hormone variants, DNA encoding the variants, vectors, host cells, pegylated forms of the variants, as well as methods of making the variants are disclosed.
摘要翻译： 公开了人生长激素变体，编码变体的DNA，载体，宿主细胞，变体的聚乙二醇化形式，以及制备变体的方法。
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公开(公告)号：US6136563A
公开(公告)日：2000-10-24
申请号：US28652
申请日：1998-02-24
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K38/27 , A61K47/48 , A61P3/00 , A61P3/10 , A61P5/00 , A61P5/08 , A61P5/12 , A61P13/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07K1/107 , C07K14/61 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/18 , C12N15/63 , C12P21/02 , C12R1/19
CPC分类号： A61K47/48215 , C07K14/61 , A61K38/00 , C07K2319/00 , Y10S514/866 , Y10S930/12
摘要： Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugated to one or more chemical groups, such as poly(ethylene glycol), which is believed to prolong the in vivo half-life of the variants.
摘要翻译： 公开了对生长激素受体具有增强的亲和力的人生长激素变体。 还公开了与一种或多种化学基团缀合的人生长激素变体，例如聚（乙二醇），其被认为延长了变体的体内半衰期。
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公开(公告)号：US07094869B2
公开(公告)日：2006-08-22
申请号：US10224640
申请日：2002-08-19
申请人： Todd C. Somers , Kathleen A. Elias , Ross G. Clark , Robert S. McDowell , Mark S. Stanley , John P. Burnier , Thomas E. Rawson
发明人： Todd C. Somers , Kathleen A. Elias , Ross G. Clark , Robert S. McDowell , Mark S. Stanley , John P. Burnier , Thomas E. Rawson
IPC分类号： C07K5/08
CPC分类号： C07K16/22 , A61K38/25 , A61K38/27 , A61K38/30 , C07D209/20 , C07D211/62 , C07D401/12 , C07D403/12 , C07K5/0202 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/0812 , C07K5/1016 , C07K5/1024 , C07K7/02 , C07K7/06 , C07K14/60 , A61K2300/00
摘要： The present invention comprises growth hormone releasing peptides/peptidomimetics (GHRP) capable of causing release of growth hormone from the pituitary. Compositions containing the GHRP's of this invention are used to promote growth in mammals either alone or in combination with other growth promoting compounds, especially IGF-1. In a method of this invention GHRP's in combination with IGF-1 are used to treat Type II diabetes. An exemplary compound of this invention is provided below
摘要翻译： 本发明包括生长激素释放肽/肽模拟物（GHFP），其能够从垂体中释放生长激素。 包含本发明的GHRP的组合物用于促进哺乳动物单独或与其它生长促进化合物，特别是IGF-1组合的生长。 在本发明的方法中，GHRP与IGF-1组合用于治疗II型糖尿病。 以下提供本发明的示例性化合物
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公开(公告)号：US6004931A
公开(公告)日：1999-12-21
申请号：US28648
申请日：1998-02-24
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K38/27 , A61K47/48 , A61P3/00 , A61P3/10 , A61P5/00 , A61P5/08 , A61P5/12 , A61P13/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07K1/107 , C07K14/61 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/18 , C12N15/63 , C12P21/02 , C12R1/19
CPC分类号： A61K47/48215 , C07K14/61 , A61K38/00 , C07K2319/00 , Y10S514/866 , Y10S930/12
摘要： Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugated to one or more chemical groups, such as poly(ethylene glycol), which is believed to prolong the in vivo half-life of the variants.
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