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公开(公告)号:US08110548B2
公开(公告)日:2012-02-07
申请号:US11934582
申请日:2007-11-02
申请人: Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人: Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号: A61K38/00
CPC分类号: C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要: The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译: 本发明涉及一种治疗软骨障碍的方法,包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触,IGF-1类似物对IGF结合蛋白(IGFBPs)或IGFBP替代肽具有改变的亲和性,所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号:US06608028B1
公开(公告)日:2003-08-19
申请号:US09723251
申请日:2000-11-27
申请人: Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人: Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号: A61K3810
CPC分类号: C07K7/08 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , Y10S930/12 , Y10S930/26 , Y10S930/27 , A61K2300/00
摘要: Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
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公开(公告)号:US06693079B1
公开(公告)日:2004-02-17
申请号:US09724157
申请日:2000-11-28
IPC分类号: A61K3810
CPC分类号: C07K7/08 , A61K38/30 , C07K14/4743 , C07K2319/00 , Y10S930/12 , A61K2300/00
摘要: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
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公开(公告)号:US06693078B1
公开(公告)日:2004-02-17
申请号:US09724095
申请日:2000-11-28
IPC分类号: A61K3810
CPC分类号: C07K7/08 , A61K38/30 , C07K14/4743 , C07K2319/00 , Y10S930/12 , A61K2300/00
摘要: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
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公开(公告)号:US06683053B1
公开(公告)日:2004-01-27
申请号:US09723913
申请日:2000-11-28
IPC分类号: A61K3810
CPC分类号: C07K7/08 , A61K38/30 , C07K14/4743 , C07K2319/00 , Y10S930/12 , A61K2300/00
摘要: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
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公开(公告)号:US6121416A
公开(公告)日:2000-09-19
申请号:US825852
申请日:1997-04-04
IPC分类号: G01N33/566 , A61K31/427 , A61K31/4965 , A61K38/00 , A61K38/22 , A61K38/27 , A61K38/28 , A61K38/30 , A61K45/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P13/12 , A61P25/00 , C07K7/00 , C07K7/08 , C07K14/00 , C07K14/47 , C07K16/18 , C07K19/00 , C12N15/09 , A61K38/04 , A61K38/16 , C07K14/65
CPC分类号: C07K7/08 , A61K38/30 , C07K14/4743 , C07K2319/00 , Y10S930/12
摘要: Compounds are provided that prevent the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal
摘要翻译: 提供了防止IGF与其任何一种结合蛋白而不是人IGF受体的相互作用的化合物。 这些IGF激动剂化合物(其包括肽)可用于增加哺乳动物中活性IGF的血清和组织水平
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公开(公告)号:US06750321B1
公开(公告)日:2004-06-15
申请号:US09723185
申请日:2000-11-27
申请人: Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicolas J. Skelton
发明人: Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicolas J. Skelton
IPC分类号: C07K750
CPC分类号: C07K7/08 , A61K38/00 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , Y10S930/27 , A61K2300/00
摘要: Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
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公开(公告)号:US06635619B1
公开(公告)日:2003-10-21
申请号:US09724127
申请日:2000-11-28
IPC分类号: A61K3810
CPC分类号: C07K7/08 , A61K38/30 , C07K14/4743 , C07K2319/00 , Y10S930/12 , A61K2300/00
摘要: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which includes peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
摘要翻译: 提供了抑制IGF与其任何一种结合蛋白而不是人IGF受体的相互作用的化合物。 这些IGF激动剂化合物(其包括肽)可用于增加哺乳动物中活性IGF的血清和组织水平。
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公开(公告)号:US06632794B1
公开(公告)日:2003-10-14
申请号:US09723547
申请日:2000-11-28
IPC分类号: A61K3810
CPC分类号: C07K7/08 , A61K38/30 , C07K14/4743 , C07K2319/00 , Y10S930/12 , A61K2300/00
摘要: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
摘要翻译: 提供了抑制IGF与其任何一种结合蛋白而不是人IGF受体的相互作用的化合物。 这些IGF激动剂化合物(包括肽)可用于增加哺乳动物中活性IGF的血清和组织水平。 PTEXT>
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公开(公告)号:US06251865B1
公开(公告)日:2001-06-26
申请号:US09052888
申请日:1998-03-31
IPC分类号: A61K3808
CPC分类号: C07K7/08 , A61K38/30 , C07K14/4743 , C07K2319/00 , Y10S930/12 , A61K2300/00
摘要: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
摘要翻译: 提供了抑制IGF与其任何一种结合蛋白而不是人IGF受体的相互作用的化合物。 这些IGF激动剂化合物(其包括肽)可用于增加哺乳动物中活性IGF的血清和组织水平。
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