公开(公告)号：US20210009568A1

公开(公告)日：2021-01-14

申请号：US16942021

申请日：2020-07-29

Applicant: Foghorn Therapeutics Inc.

Inventor： Qianhe Zhou ,  Michael Bocker ,  David Simon Millan ,  Ho Man Chan ,  Luis Soares ,  Matthew Russell Netherton ,  Sabine K. Ruppel ,  Zhaoxia Yang ,  Jason T. Lowe ,  Francois Brucelle

IPC: C07D403/14 ,  A61K9/16 ,  A61P35/00 ,  A61K45/06

Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.

公开(公告)号：US20240376121A1

公开(公告)日：2024-11-14

申请号：US18288504

申请日：2022-05-10

Applicant: Foghorn Therapeutics Inc.

Inventor： Matthew NETHERTON ,  Francois BRUCELLE ,  Jing DENG ,  Johannes H. VOIGT ,  Kevin J. WILSON

IPC: C07D495/04 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/5377 ,  C07D495/14 ,  C07D519/00

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

公开(公告)号：US20230365560A1

公开(公告)日：2023-11-16

申请号：US18315526

申请日：2023-05-11

Applicant: Foghorn Therapeutics Inc.

Inventor： Shawn E.R. SCHILLER ,  Solymar NEGRETTI ,  David S. HUANG ,  Kevin J. WILSON ,  Melek Nihan UCISIK ,  Richard CALDWELL

IPC: C07D471/04 ,  A61K45/06 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K45/06 ,  C07D519/00 ,  C07B2200/05

Abstract: The present disclosure features compounds of Formula I,




or pharmaceutically acceptable salts thereof, and formulations containing the same. Methods of treating BAF complex-related disorders, such as cancer, are also disclosed.

公开(公告)号：US11773085B2

公开(公告)日：2023-10-03

申请号：US16942021

申请日：2020-07-29

Applicant: Foghorn Therapeutics Inc.

Inventor： Qianhe Zhou ,  Michael Bocker ,  David Simon Millan ,  Ho Man Chan ,  Luis Soares ,  Matthew Russell Netherton ,  Sabine K. Ruppel ,  Zhaoxia Yang ,  Jason T. Lowe ,  Francois Brucelle

IPC: A61P35/00 ,  A61K31/551 ,  C07D519/00 ,  C07D403/14 ,  A61K9/16 ,  A61K45/06

CPC classification number: C07D403/14 ,  A61K9/1605 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.

公开(公告)号：US11767330B2

公开(公告)日：2023-09-26

申请号：US17858875

申请日：2022-07-06

Applicant: Foghorn Therapeutics Inc.

Inventor： Chong-Hui Gu ,  Joshua D. Waetzig

IPC: C07D519/00 ,  C07D201/00 ,  A61K31/4545

CPC classification number: C07D519/00 ,  C07B2200/13

Abstract: The present disclosure features citrate salts and pharmaceutical compositions useful for the treatment of BAF complex-related disorders. Also disclosed are methods for preparing compounds.

公开(公告)号：US20230079819A1

公开(公告)日：2023-03-16

申请号：US17425140

申请日：2020-01-29

Applicant: Foghorn Therapeutics Inc.

Inventor： Rishi G. VASWANI ,  Neville John ANTHONY ,  David Simon MILLAN ,  Shawn E.R. SCHILLER ,  Kevin J. WILSON ,  David S. HUANG

IPC: C07D417/14 ,  A61P35/00 ,  C07D498/04 ,  C07D417/12 ,  C07D487/04 ,  C07D491/08 ,  C07D471/04 ,  C07D491/107 ,  C07D491/048

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

公开(公告)号：US20230065463A1

公开(公告)日：2023-03-02

申请号：US17425013

申请日：2020-01-29

Applicant: Foghorn Therapeutics Inc.

Inventor： Sabine K. RUPPEL ,  Zhaoxia YANG ,  Jason T. LOWE ,  Johannes H. VOIGT ,  Matthew NETHERTON ,  Francois BRUCELLE

IPC: C07D495/04 ,  A61P35/00 ,  C07D519/00 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.

公开(公告)号：US11485732B2

公开(公告)日：2022-11-01

申请号：US17162103

申请日：2021-01-29

Applicant: Foghorn Therapeutics Inc.

Inventor： Rishi G. Vaswani ,  David S. Huang

IPC: C07D417/14 ,  A61P35/02 ,  A61P35/00

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

公开(公告)号：US11414416B1

公开(公告)日：2022-08-16

申请号：US17478505

申请日：2021-09-17

Applicant: Foghorn Therapeutics Inc.

Inventor： Sabine K. Ruppel ,  Zhaoxia Yang ,  Jason T. Lowe ,  Johannes H. Voigt ,  Matthew Netherton

IPC: C07D471/04 ,  C07D498/10 ,  C07D519/00 ,  C07D401/14

Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.

公开(公告)号：US20220016083A1

公开(公告)日：2022-01-20

申请号：US17295327

申请日：2019-11-21

Applicant: Foghorn Therapeutics Inc.

Inventor： Richard C. CENTORE ,  Lan XU ,  David LAHR

IPC: A61K31/4184 ,  A61K45/06 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/5377 ,  A61P35/00

Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as melanoma, prostate cancer, breast cancer, bone cancer, renal cell carcinoma, and hematologic cancer.