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公开(公告)号：US20240124543A1
公开(公告)日：2024-04-18
申请号：US18497083
申请日：2023-10-30
申请人： HCW Biologics, Inc.
发明人： Hing Wong
IPC分类号： C07K14/54 , C07K14/71 , C07K14/715 , C07K14/745 , C07K16/28
CPC分类号： C07K14/5434 , C07K14/54 , C07K14/5418 , C07K14/71 , C07K14/7155 , C07K14/745 , C07K16/283 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C07K2319/30
摘要： Provided herein are multi-chain chimeric polypeptides that include:
(a) a first chimeric polypeptide including a first target-binding domain, a soluble tissue factor domain, and a first domain of a pair of affinity domains; and (b) a second chimeric polypeptide including a second domain of a pair of affinity domains and a second target-binding domain, where the first chimeric polypeptide and the second chimeric polypeptide associate through the binding of the first domain and the second domain of the pair of affinity domains. Also provided here are methods of using these multi-chain chimeric polypeptides and nucleic acids encoding these multi-chain chimeric polypeptides.-
公开(公告)号：US11738052B2
公开(公告)日：2023-08-29
申请号：US16906781
申请日：2020-06-19
申请人： HCW Biologies, Inc.
发明人： Hing C. Wong
CPC分类号： A61K35/17 , C07K14/5418 , C07K14/5434 , C07K14/5443 , C07K16/4283 , C07K2319/74
摘要： The present disclosure relates to methods that include the use of a first multi-chain chimeric polypeptide and a second multi-chain chimeric polypeptide for stimulating the NK cells, inducing or increasing proliferation of the NK cells, inducing differentiation of the NK cells, and treating a subject in need thereof using activated NK cells.
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公开(公告)号：US20230174666A1
公开(公告)日：2023-06-08
申请号：US17922067
申请日：2021-04-29
申请人： HCW Biologics, Inc.
发明人： Hing C. Wong , Bai Liu , Lin Kong , Xiaoyun Zhu , Catherine Spanoudis
CPC分类号： C07K16/2896 , A61K35/17 , A61K38/1774 , A61K45/06 , A61K39/00 , C07K2317/21 , C07K2317/24 , C07K2317/622
摘要： Provided herein are proteins comprising an anti-CD26 antigen-binding domain. Also provided herein are methods of treating an aging-related disease or an inflammatory disease in a subject that include administering to the subject one of these proteins or a cell expressing one of these proteins.
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公开(公告)号：US20230128292A1
公开(公告)日：2023-04-27
申请号：US18047751
申请日：2022-10-19
申请人： HCW Biologics, Inc.
发明人： Hing Wong
IPC分类号： C07K14/54 , C07K14/71 , C07K14/715 , C07K14/745 , C07K16/28
摘要： Provided herein are multi-chain chimeric polypeptides that include:
(a) a first chimeric polypeptide including a first target-binding domain, a soluble tissue factor domain, and a first domain of a pair of affinity domains; and (b) a second chimeric polypeptide including a second domain of a pair of affinity domains and a second target-binding domain, where the first chimeric polypeptide and the second chimeric polypeptide associate through the binding of the first domain and the second domain of the pair of affinity domains. Also provided here are methods of using these multi-chain chimeric polypeptides and nucleic acids encoding these multi-chain chimeric polypeptides.-
公开(公告)号：US20220073578A1
公开(公告)日：2022-03-10
申请号：US17336183
申请日：2021-06-01
申请人： HCW Biologics, Inc.
发明人： Hing C. Wong , Xiaoyun Zhu , Bai Liu , Pallavi Chaturvedi , Varghese George
摘要： Provided herein are methods of killing or reducing the number of naturally-occurring and/or treatment-induced senescent cells and diseased cells in a subject in need thereof, decreasing the accumulation of naturally-occurring and/or treatment-induced senescent cells and diseased cells in a subject in need thereof, that include administering to the subject a therapeutically effective amount of one or more common gamma-chain family cytokine receptor activating agent(s) and/or one or more agent(s) that result(s) in a decrease in the activation of a TGF-β receptor.
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公开(公告)号：US20210338724A1
公开(公告)日：2021-11-04
申请号：US17174259
申请日：2021-02-11
申请人： HCW Biologics, Inc.
发明人： Hing C. Wong
IPC分类号： A61K35/17 , C07K16/28 , C12N5/0783 , C07K14/705 , C07K16/36 , A61K45/06
摘要： Provided herein are methods of treating an aging-related disease or inflammatory disease in a subject that include (i) a therapeutically effective amount of an NK cell activating agent and/or an NK cell and/or monoclonal antibody; and (ii) a therapeutically effective amount of a Treg cell activating agent and/or a Treg cell and/or a monoclonal antibody and/or AGE inhibitor.
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公开(公告)号：US20210277054A1
公开(公告)日：2021-09-09
申请号：US17173767
申请日：2021-02-11
申请人： HCW Biologics, Inc.
发明人： Hing C. Wong , Jin-an Jiao , Caitlin Prendes
IPC分类号： C07K1/22 , C07K16/36 , C07K14/745 , C07K14/715 , C07K14/54 , B01D15/38 , B01D61/02 , B01D61/14 , B01D61/58
摘要： An affinity chromatography resin comprising an anti-tissue factor antibody or antigen-binding fragment thereof attached to a base resin, and methods of using the same.
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公开(公告)号：US20210268022A1
公开(公告)日：2021-09-02
申请号：US17173806
申请日：2021-02-11
申请人： HCW Biologics, Inc.
发明人： Hing C. Wong , Niraj Shresha , Varghese George , Michael Dee
IPC分类号： A61K35/17 , C12N5/0783 , C07K14/705
摘要： Provided herein are methods of stimulating or increasing the proliferation of a Treg cell, compositions including a population of Treg cells generated by these methods, and methods of treating a subject using these compositions.
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公开(公告)号：US20210070825A1
公开(公告)日：2021-03-11
申请号：US16952848
申请日：2020-11-19
申请人： HCW Biologics, Inc.
发明人： Hing Wong
IPC分类号： C07K14/54 , C07K14/71 , C07K14/715 , C07K14/745 , C07K16/28
摘要： Provided herein are multi-chain chimeric polypeptides that include:
(a) a first chimeric polypeptide including a first target-binding domain, a soluble tissue factor domain, and a first domain of a pair of affinity domains; and (b) a second chimeric polypeptide including a second domain of a pair of affinity domains and a second target-binding domain, where the first chimeric polypeptide and the second chimeric polypeptide associate through the binding of the first domain and the second domain of the pair of affinity domains. Also provided here are methods of using these multi-chain chimeric polypeptides and nucleic acids encoding these multi-chain chimeric polypeptides.
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