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773 条记录 (耗时 0.04 秒)

    Derivatives of sobetirome
    21.
    发明授权
    Derivatives of sobetirome 有权

    公开(公告)号：US11578032B2

    公开(公告)日：2023-02-14

    申请号：US16969793

    申请日：2019-02-13

    申请人： OREGON HEALTH & SCIENCE UNIVERSITY

    发明人： Thomas Scanlan

    IPC分类号： C07C233/40 ,  C07C233/11 ,  C07C233/13 ,  C07C233/22

    摘要： Compounds are provided that function as thyromimetics, which compounds have utility for treating diseases such as neurodegenerative disorders. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation. Such compounds have the structure of Formula (I) as shown herein, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof.

    DEVICE FOR ANATOMICAL SENSING SYSTEM-GUIDED ENDORECTAL PROSTATE BIOPSY
    22.
    发明申请
    DEVICE FOR ANATOMICAL SENSING SYSTEM-GUIDED ENDORECTAL PROSTATE BIOPSY 有权

    公开(公告)号：US20230028963A1

    公开(公告)日：2023-01-26

    申请号：US17960636

    申请日：2022-10-05

    申请人： Oregon Health & Science University

    发明人： Fergus Coakley ,  Stevan Wittenbrock ,  Forrest Seitz ,  Christopher J. Jensen ,  Daniel R. Baker

    IPC分类号： A61B34/20 ,  A61B10/02 ,  A61B10/04 ,  G01R33/28

    摘要： An anatomical sensing system-guided prostate procedure device that includes a housing having a proximal end and a distal end. The housing may be divided into a distal housing section, amid housing section, and a proximal housing section, wherein the distal housing section is configured for insertion into the anus and retention in the rectum of a subject. The device further includes an instrument convergence point disposed between the proximal end and the distal end, the convergence point configured to allow an instrument pass though the instrument convergence point at a variable angle; and an instrument angle orienting system at the proximal end of the housing, the angle orienting system directing an orientation of the variable angle about the convergence point. Methods of the using an anatomical sensing system-guided prostate procedure device and system including the same.

    Automated detection of shadow artifacts in optical coherence tomography angiography
    26.
    发明授权
    Automated detection of shadow artifacts in optical coherence tomography angiography 有权

    公开(公告)号：US11302043B2

    公开(公告)日：2022-04-12

    申请号：US16803629

    申请日：2020-02-27

    申请人： Oregon Health & Science University

    发明人： Acner Camino ,  David Huang ,  Yali Jia

    IPC分类号： G06T11/00 ,  A61B3/10 ,  A61B5/00 ,  G06T7/00 ,  A61B5/026

    摘要： Disclosed herein are methods and systems for automated detection of shadow artifacts in optical coherence tomography (OCT) and/or OCT angiography (OCTA). The shadow detection includes applying a machine-learning algorithm to the OCT dataset and the OCTA dataset to detect one or more shadow artifacts in the sample. The machine-learning algorithm is trained with first training data from first training samples that include manufactured shadows and no perfusion defects and second training data from second training samples that include perfusion defects and no manufactured shadows. The shadow artifacts in the OCTA dataset and/or OCT dataset may be suppressed to generate a shadow-suppressed OCTA dataset and/or a shadow-suppressed OCT dataset, respectively. Other embodiments may be described and claimed.

    Enteral feeding tube housing and fixation devices
    28.
    发明授权
    Enteral feeding tube housing and fixation devices 有权

    公开(公告)号：US11213461B2

    公开(公告)日：2022-01-04

    申请号：US16335167

    申请日：2017-10-03

    申请人： Oregon Health & Science University

    发明人： James P. Dolan ,  Younes Jahangiri Noudeh ,  Niloy Ghosh

    IPC分类号： A61J15/00 ,  A61M25/02

    摘要： Enteric feeding tube housings configured to secure a feeding tube to the body are disclosed. The housing includes a disc having a hole configured to accommodate the feeding tube and two or more holes configured to accommodate fasteners. Also disclosed are enteric feeding tube housings that include a disc having a hole configured to accommodate the feeding tube and two or more holes configured to accommodate fasteners, and a plurality of fasteners. Also disclosed are surgical kits that include a housing, a plurality of fasteners, and a plurality of locking devices configured to adjustably secure the fasteners in the fastener receiving holes, and method of using the disclosed devices.

    MINERALIZATION OF CELL-LADEN MATRICES
    29.
    发明申请
    MINERALIZATION OF CELL-LADEN MATRICES 有权

    公开(公告)号：US20210402053A1

    公开(公告)日：2021-12-30

    申请号：US17279437

    申请日：2019-09-25

    申请人： Oregon Health & Science University

    发明人： Luiz E. Bertassoni

    IPC分类号： A61L27/04 ,  A61L27/24 ,  A61L27/12 ,  A61L27/38

    摘要： This disclosure relates to methods of mineralizing cell-laden matrices. Disclosed herein are cell-laden matrix compositions. Also disclosed herein are methods of selectively mineralizing a cell-laden matrix. Methods of culturing biomimetic bone tissue are disclosed herein. Also disclosed herein are kits containing compositions disclosed herein or portions thereof.