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24 条记录 (耗时 0.018 秒)

    SPIROCYCLIC MORPHINANS AND USE THEREOF
    21.
    发明申请
    SPIROCYCLIC MORPHINANS AND USE THEREOF 审中-公开

    公开(公告)号：US20170190702A1

    公开(公告)日：2017-07-06

    申请号：US15313323

    申请日：2015-05-26

    申请人： Purdue Pharma L.P.

    发明人： Mark A. Youngman ,  Laykea Tafesse ,  R. Richard Goehring ,  Jianming Yu

    IPC分类号： C07D471/20 ,  C07B59/00

    CPC分类号： C07D471/20 ,  C07B59/002 ,  C07B2200/05 ,  C07D489/09

    摘要： In one aspect, the invention provides compounds of Formula I: (I) and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, Y, Za are defined as set forth in the disclosure. The invention also provides compounds of any one of Formulae II to VII, IA to IC, and IIA to IIC, and pharmaceutically acceptable salts and solvates thereof. Other aspects of the invention include the use of compounds of Formulae I to VII, IA to IC, and IIA to IIC, and pharmaceutically acceptable salts and solvates thereof for the treatment of disorders responsive to modulation of one or more opioid receptors. In certain embodiments, the Compounds of the Invention are useful for treating pain.