公开(公告)号：US11596615B2

公开(公告)日：2023-03-07

申请号：US16932236

申请日：2020-07-17

申请人： Temple University—Of The Commonwealth System Of Higher Education

发明人： Salim Merali ,  Carlos A. Barrero ,  Wayne E. Childers ,  George C. Morton

IPC分类号： A61K31/198 ,  A61P3/08

摘要： Compounds of Formula (I), and pharmaceutically effective salts thereof; wherein R1-R14, m, n, o, p, q and r are as defined herein, are provided for treatment of for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.

公开(公告)号：US20230066836A1

公开(公告)日：2023-03-02

申请号：US17789893

申请日：2020-12-22

申请人： NextFerm Technologies Ltd.

发明人： Gai Ben-Dor ,  Yael Lifshitz ,  Avi Yosef ,  Tzafra Cohen ,  Arkadiy Haikin ,  Masha Fridman ,  Marina Khutorian ,  Sivan Mor Danan

IPC分类号： A61K36/07 ,  A61K31/122 ,  A61K33/34 ,  A61K33/00 ,  A61K33/30 ,  A61K31/198 ,  A61P39/06

摘要： The present invention relates to processes for preparing antioxidant liquid extracts and compositions and uses of such antioxidant liquid extracts and compositions. Also provided are novel antioxidant liquid extracts and compositions comprising astaxanthin. The antioxidant liquid extracts and compositions inter alia exhibit high antioxidant activity.

公开(公告)号：US20230064307A1

公开(公告)日：2023-03-02

申请号：US17300593

申请日：2021-08-28

申请人： Ming C. Liau ,  Christine Liau Craig ,  Linda Liau Baker ,  John P. Fruehauf

发明人： Ming C. Liau ,  Christine Liau Craig ,  Linda Liau Baker ,  John P. Fruehauf

IPC分类号： A61K31/57 ,  A61K31/198 ,  A61K31/202 ,  A61K31/196 ,  A61K31/12

摘要： The present invention relates to the discoveries of the mechanism of wound healing, the relationship of wound healing to the evolution of cancer, and the use of such discoveries for the perfection of wound healing to avoid ugly scar and cancer evolution, and for the use to take out both cancer cells and cancer stem cells to accomplish a permanent cure of cancer.

公开(公告)号：US11590190B2

公开(公告)日：2023-02-28

申请号：US16389326

申请日：2019-04-19

申请人： Sweet Wellness AB

发明人： Per-Arne Öckerman

IPC分类号： A61K36/752 ,  A61K31/122 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/714 ,  A61K33/14 ,  A61K33/18 ,  A61K33/24 ,  A61K33/42 ,  A61K31/01 ,  A61K31/015 ,  A61K31/07 ,  A61K31/197 ,  A61K31/455 ,  A61K31/519 ,  A61K31/59 ,  A61K31/7004 ,  A61K33/06 ,  A61K35/60 ,  A61K35/744 ,  A61K35/747 ,  A23L33/175 ,  A23L33/105 ,  A23L33/115 ,  A23L33/16 ,  A23L33/15 ,  A23L33/135 ,  A23L33/155 ,  A61K31/14 ,  A61K31/198 ,  A61K31/4415 ,  A61K31/51 ,  A61K31/525 ,  A61K31/593 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K36/45

摘要： Various embodiments of the invention relate to compositions comprising vitamins, minerals and trace elements, antioxidants, amino acids, probiotics, and other components and methods for using such compositions to treat or prevent diseases associated with oxidative stress, including cardiovascular disease.

公开(公告)号：US11590090B2

公开(公告)日：2023-02-28

申请号：US17019494

申请日：2020-09-14

申请人： Anzen Pharmaceuticals, LLC

发明人： Kevin M. Strait ,  Daniel J. Strait ,  Cameron D. Kawato

IPC分类号： A61K9/24 ,  A61K31/167 ,  A61K31/198 ,  A61K9/28

摘要： An oral pharmaceutical dosage form that comprises both acetaminophen and a glutathione replenishing agent, such as N-acetylcysteine. This allows co-administering the glutathione replenishing agent along with acetaminophen, which may be beneficial in rapidly counteracting the toxic effects of acetaminophen overdose. The oral dosage form could be in the form of a tablet or capsule. The dosage form may be designed to compartmentally separate the glutathione replenishing agent from having chemical interaction with the acetaminophen. The dosage form may be designed to mask the taste or smell of the glutathione replenishing agent.

公开(公告)号：US20230054825A1

公开(公告)日：2023-02-23

申请号：US17967332

申请日：2022-10-17

申请人： Amneal Pharmaceuticals LLC

发明人： Richard D'Souza ,  Hester Visser ,  Suneel Gupta

IPC分类号： A61K31/198 ,  A61K9/50 ,  A61P25/16

摘要： The invention provides oral dosing regimens of controlled release levodopa compositions for use in treating patients with Parkinson's disease, primary parkinsonism/idiopathic parkinsonism, post-encephalitic parkinsonism, parkinsonism that may follow carbon monoxide intoxication, or parkinsonism that may follow manganese intoxication.

公开(公告)号：US11582988B2

公开(公告)日：2023-02-21

申请号：US17034905

申请日：2020-09-28

申请人： AJINOMOTO CO., INC.

发明人： Sachiko Yonemaru ,  Koji Haga ,  Yuki Miyazawa ,  Susumu Shibahara

IPC分类号： A23K20/142 ,  A23K20/158 ,  A23K20/174 ,  A23K40/35 ,  A23K50/10 ,  A61K31/198 ,  A61K31/405 ,  A61K31/455 ,  A61K31/519 ,  A61K31/714 ,  A23K40/25

摘要： Dispersion type feed additive compositions for ruminants, containing (A) at least one selected from hydrogenated vegetable oil and hydrogenated animal oil each having a melting point of higher than 50° C. and lower than 90° C., (B) not less than 0.01 wt % and not more than 6 wt % of a surfactant, (C) not less than 16 wt % and not more than 72 wt % of a biologically active substance (excluding L-lysine and a salt thereof), and (D) not less than 1 wt % and not more than 40 wt % of L-lysine or a salt thereof, contain a biologically active substance at a high concentration, show high protection in the rumen, and are also superior in dissolution in the intestinal tract.

公开(公告)号：US20230051742A1

公开(公告)日：2023-02-16

申请号：US17758759

申请日：2021-01-13

申请人： IntraBio Ltd.

发明人： Michael STRUPP

IPC分类号： A61K31/198 ,  A61P25/28

摘要： The present disclosure provides methods of treating, preventing, or delaying the onset of a late-onset neurodegenerative disease, e.g., Niemann-Pick type C, or a symptom thereof in a subject in need thereof, comprising administering a therapeutically effective amount of acetyl-leucine to the subject, wherein the subject is heterozygous NPC1 gene mutation carrier.

公开(公告)号：US11576885B2

公开(公告)日：2023-02-14

申请号：US17064000

申请日：2020-10-06

申请人： THE CHILDREN'S HOSPITAL OF PHILADELPHIA

发明人： Akiva S. Cohen

IPC分类号： A61K31/198 ,  A61P25/00 ,  A61K9/00

摘要： Compositions and methods are provided for the alleviation of pathology induced by traumatic brain injury.

公开(公告)号：US11576883B2

公开(公告)日：2023-02-14

申请号：US16287437

申请日：2019-02-27

申请人： Iowa State University Research Foundation, Inc. ,  Board of Regents, The University of Texas System

发明人： Anumantha G. Kanthasamy ,  Ahmed Abdalla ,  Gregory Phillips ,  Nicholas Backes ,  Andrew D. Ellington ,  Ross Thyer

IPC分类号： A61K31/198 ,  C12N9/02 ,  A61P25/28 ,  A61P25/24 ,  A61K9/00 ,  A61K35/741 ,  A61P25/16 ,  A61K35/00

摘要： The present invention generally provides methods and compositions for the treatment of Parkinson's disease and depression and/or anxiety. The invention relates to recombinant microorganisms, particularly gut-colonizing probiotics, modified to produce L-DOPA.